Clinical and upper airway characteristics of 3715 patients with the Omicron variant of SARS-Cov-2 in Changchun, China

Sha, Jichao; Meng, Cuida; Sun, Jing; Sun, Li; Gu, Rui; Liu, Junzhi; Zhu, Xuewei; Zhu, Dongdong

doi:10.1016/j.jiph.2023.01.013

Cited by 17 publications

(16 citation statements)

References 22 publications

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“…In our study, the most common symptoms observed were cough with or without sputum, fever, and sore throat. These findings align with the research conducted in Changchun, China, where the Omicron variant emerged in March 2022 21 . In that study, the most prevalent symptoms reported were fever, cough, and sore throat.…”

Section: Discussionsupporting

confidence: 90%

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Clinical characteristics and factors for serious outcomes among outpatients infected with the Omicron subvariant BF.7

Yang,

Wang,

Zhang

et al. 2023

Journal of Medical Virology

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To evaluate clinical characteristics and identify risk factors associated with severe outcomes in outpatients infected with the Omicron subvariant BF.7, data were collected from outpatients diagnosed with Corona Virus Disease 2019 from December 19, 2022 to January 5, 2023. Clinical characteristics were analyzed using descriptive statistics. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with serious outcomes. Variables with a p < 0.10 in the univariate analysis were included in the multivariate model. Our study analyzed 770 patients, of whom 380 (49.4%) were male, with a median age of 59. The most common symptoms reported were cough (71.2%), fever (64.7%), and sore throat (37.7%). Fever lasted an average of 5.93 ± 3.37 days for the general population and 10.64 ± 7.12 days for impaired‐immunity patients. Most cases were mild (68.7%), followed by moderate (27.1%). Severe cases accounted for 2.2%, with 0.5% critically ill. Serious outcomes occurred in 4.2% of cases, with 11 deaths during follow‐up. Underlying‐diseases patients had a higher rate of serious outcomes. Factors associated with serious outcomes included receiving a three‐dose vaccination (odds ratio [OR] = 0.324, 95% confidence interval [CI]: 0.113–0.932, p = 0.037), male gender (OR = 2.890, 95% CI: 1.107–7.548, p = 0.030), age (OR = 1.060, 95% CI: 1.024–1.097, p = 0.001), and chest tightness or dyspnea at the time of visit (OR = 4.861, 95% CI: 2.054–11.507, p < 0.001). Our study found that cough, fever, and sore throat were the most common symptoms reported by patients. Receiving a three‐dose vaccination was protective, while male gender, age, and chest tightness or dyspnea were identified as risk factors for serious outcomes.

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Section: Discussionsupporting

confidence: 90%

“…These findings align with the research conducted in Changchun, China, where the Omicron variant emerged in March 2022. 21 In that study, the most prevalent symptoms reported were fever, cough, and sore throat.…”

Section: Discussionmentioning

confidence: 85%

Clinical characteristics and factors for serious outcomes among outpatients infected with the Omicron subvariant BF.7

Yang,

Wang,

Zhang

et al. 2023

Journal of Medical Virology

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“…High blood glucose causes an increase of dicarbonyl molecules in the human body, inhibits the antibacterial and immune function of β-defensins and increases the susceptibility of patients, particularly among those with uncontrolled or poorly controlled blood glucose [ 14 ]. Previous studies have shown that high blood glucose reduces peripheral blood lymphocytes and increases leukocytes in patients with COVID-19, leading to immune system overactivation and more severe clinical symptoms [ 5 , 15 ]. Although some of the research indicates that neutrophils and leukocytes help distinguish asymptomatic and moderate COVID-19 [ 16 ], this study found that the differences in lymphocytes and leukocytes among patients are not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…A relatively small number develop acute respiratory distress syndrome, multiple organ failure or even death, as observed mainly in older patients with underlying medical conditions [ 2 ]. The evidence suggests that elderly patients with chronic diseases such as hypertension, carotid artery diseases and diabetes are more susceptible to COVID-19 [ 3 – 5 ], and according to China’s census data, nearly half of the older population (in which the average life expectancy is continually increasing) suffer from diabetes [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Severity of COVID-19 infection in patients with COVID-19 combined with diabetes

Lu,

Liu,

et al. 2024

J Health Popul Nutr

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Purpose This study aimed to analyse the correlation between blood glucose control and the severity of COVID-19 infection in patients with diabetes. Methods Clinical and imaging data of a total of 146 patients with diabetes combined with COVID-19 who visited our hospital between December 2022 and January 2023 were retrospectively collected. The patients were divided into the ‘good blood glucose control’ group and the ‘poor blood glucose control’ group based on an assessment of their blood glucose control. The clinical data, computed tomography (CT) appearance and score and the severity of COVID-19 infection of the two groups were compared, with the severity of COVID-19 infection being the dependent variable to analyse other influencing factors. Results The group with poor blood glucose control showed a higher lobar involvement degree and total CT severity score (CTSS) than the group with good blood glucose control (13.30 ± 5.25 vs. 10.38 ± 4.84, p < 0.05). The two groups exhibited no statistically significant differences in blood lymphocyte, leukocyte, C-reaction protein, pleural effusion, consolidation, ground glass opacity or crazy-paving signs. Logistic regression analysis showed that the total CTSS significantly influences the clinical severity of patients (odds ratio 1.585, p < 0.05), whereas fasting plasma glucose and blood glucose control are not independent factors influencing clinical severity (both p > 0.05). The area under the curve (AUC) of CTSS prediction of critical COVID-19 was 0.895 with sensitivity of 79.3% and specificity of 88.1% when the threshold value is 12. Conclusion Blood glucose control is significantly correlated with the CTSS; the higher the blood glucose is, the more severe the lung manifestation. The CTSS can also be used to evaluate and predict the clinical severity of COVID-19.

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Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Patients with Rheumatic Diseases and Serum Antibody Changes Post-Omicron Variant Infection

Zhang,

Li,

Dai

et al. 2024

Rheumatol Ther

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Clinical and upper airway characteristics of 3715 patients with the Omicron variant of SARS-Cov-2 in Changchun, China

Cited by 17 publications

References 22 publications

Clinical characteristics and factors for serious outcomes among outpatients infected with the Omicron subvariant BF.7

Clinical characteristics and factors for serious outcomes among outpatients infected with the Omicron subvariant BF.7

Severity of COVID-19 infection in patients with COVID-19 combined with diabetes

Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Patients with Rheumatic Diseases and Serum Antibody Changes Post-Omicron Variant Infection

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