Clinical And Urodynamic Effects of Propiverine in Patients Suffering from Urgency and Urge Incontinence

Abstract

The efficacy and tolerability of propiverine hydrochloride (15, off 45, 60 mg/d) were evaluated in the treatment of 185 patients suffering from urgency/urge incontinence in an open, randomized, multicentre parallel-group trial lasting 21 days. The effects on bladder volume and pressure were assessed on the basis of urodynamics and micturition frequency. Subjective adverse reactions were recorded. The bladder capacity and compliance increased and bladder pressure decreased in a dose dependent manner following therapy with 15, 30, 45 and 60 mg/d. In 70% of the patients a decrease in micturition frequency was observed after 15 mg/d, and in 80% after 30 to 60 mg/d. Subjective anticholinergic symptoms were reported by 21, 40 and 28% of the patients following therapy with 30, 45 and 60 mg/d. 15 and 30 mg were the daily doses with the most favourable ratio of efficacy in micturition frequency to tolerability. The results suggest that propiverine is a safe and effective drug for the treatment of urgency and urge incontinence. Individual treatment with an initial dosage of 30 mg/d should be recommended.

Efficacy and Cardiac Safety of Propiverine in Elderly Patients – A Double–Blind, Placebo–Controlled Clinical Study

“…In agreement with previous studies [20, 21, 22, 23, 24], propiverine was very well tolerated in the elderly patient population. The incidence of adverse events was very low, reflecting the well–known experience that effective treatment correlates with minor complaints of undesirable effects [21].…”

“…Numerous previous studies have demonstrated the efficacy of propiverine in the treatment of urgency and urge incontinence [20, 21, 22, 23, 24]. Comparable improvements have been documented by applying invasive cystometric and non– invasive parameters of micturition diaries.…”

“…Comparable improvements have been documented by applying invasive cystometric and non– invasive parameters of micturition diaries. In the studies described by Mazur et al [21, 22]and Voigt et al [23], micturition diaries have been used additionally to urodynamics. A significant improvement in cystometric and micturition parameters has also been reported.…”

Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic)

“…The ecacy of propiverine (15,30,45, 60 mg/d) was evaluated in 185 patients suering from urgency (n 105) and urge incontinence (n 80) in an open, randomised, multicentre parallel group trial for 21 days [40]. Of these patients, 80% suered from detrusor instability veri®ed by urodynamics.…”

Pharmacological Management of Detrusor Instability

“…Open studies in patients with detrusor overactivity have demonstrated a beneficial effect [46], and in a double-blind placebo-controlled trial of its use in detrusor hyperreflexia it has been shown to significantly increase bladder capacity and compliance compared to placebo. Dry mouth was experienced by 37% in the treatment group, as opposed to 8% in the placebo group, with dropout rates being 7% and 4.5%, respectively [47].…”