Clinical and Videodermoscopic Evaluation of the Efficacy, Safety, and Tolerability of a Shampoo Containing Ichthyol, Zanthalene, Mandelic Acid, and Honey in the Treatment of Scalp Psoriasis

Abstract

Purpose of the Study: The aim of the present prospective multicenter open study was to clinically and instrumentally evaluate the efficacy, safety, and tolerability of a shampoo, Mellis Cap® shampoo, containing ichthyol, zanthalene, mandelic acid, and honeydew honey in the treatment of mild to moderate scalp psoriasis. Procedures: Thirty subjects with mild to moderate psoriasis applied the shampoo three times a week for 12 weeks. The outcome was evaluated at 30 days (T1), 60 days (T2), and 90 days (T3) of treatment, comparing it to baseline (T0) by means of clinical and patients’ evaluation, digital photographs, and videodermoscopy. Results: Clinical and patients’ evaluation showed improvement of scalp psoriasis and itching. This was confirmed by videodermoscopy analysis with a significant reduction of scalp psoriasis severity at T2 and T3 compared to baseline. No side effects were observed or reported. Conclusions: Study treatment was well tolerated and showed significant clinical and instrumental improvement of scalp psoriasis. Mellis Cap® shampoo is a good alternative to other medicated shampoos in the treatment of mild to moderate scalp psoriasis.

Complementary and alternative medicine treatments for common skin diseases: A systematic review and meta-analysis

“…11 This study concluded that a honeydew honey shampoo mixture is a proven alternative to medicated shampoos for mild-to-moderate scalp psoriasis. 11 Lastly, a double-blind, placebo-controlled randomized clinical trial of participants with moderateto-severe psoriasis that explored the safety and efficacy of oral curcumin when used concomitantly with phototherapy established that curcumin was well tolerated and demonstrated a positive response as an adjunct to phototherapy, as 80% of subjects in both groups achieved a 90% decrease in PASI scores by the study conclusion. 30…”

“…In patients with mild-to-moderate scalp psoriasis, a prospective multicenter study examining treatment with honeydew honey added to a shampoo mixture showed improvement of clinical and patient-reported parameters. 11 This study concluded that a honeydew honey shampoo mixture is a proven alternative to medicated shampoos for mild-to-moderate scalp psoriasis. 11 …”

“… 11 This study concluded that a honeydew honey shampoo mixture is a proven alternative to medicated shampoos for mild-to-moderate scalp psoriasis. 11 …”

“…( Tables II and III ). 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46

Fig 2 The PRISMA flow diagram. PRISMA , Preferred reporting items for systematic reviews and meta-analyses.

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“…Studies included within the systematic review mostly ranged from ''low risk'' to ''some concerns,'' with one ''high risk study'' (Fig 1, Table I). [5][6][7][8][9][10][11][12][13] The Egger's test grouped by treatment showed no bias for aloe vera (AV) or turmeric. Bias was present for green tea (GT); however, further analysis through the ''fill and trim'' publication bias technique 14 deemed no publication bias.…”