Clinical-angiographic profile andcharacteristics of percutaneouscoronary interventions forthrombus-containing lesions

Abstract

Background: Clinical outcomes of percutaneous coronary interventions depend on clinical, angiographic and procedure-related characteristics. The present study aimed to analyze patients with thrombus-containing lesions to study how the variables of interest influence inhospital mortality. Methods: A retrospective study of procedures registered on the Central Nacional de Intervenções Cardiovasculares (CENIC) between 2006 and 2016, divided into three periods. Results: The sample comprised 22,587 patients. There were 22,978 procedures; in that, 25,107 vessels were treated, 23,237 (92.5%) of which with stents. The mean age of the patients was 60.9±12.1 years, 70.3% were male, and 20.5% diabetics. Of procedures, 93.8% were successful, 46.4% of which a primary intervention. Glycoprotein IIb/IIIa inhibitors were used in 15.3%, thromboaspiration in 4.3% and, drug-eluding stents were placed in 9.1% of cases. The variables that better explained mortality were the initial period of treatment, advanced age, female sex, absence of dyslipidemia, presence of diabetes, previous acute myocardial infarction, more extensive coronary artery disease, use of glycoprotein IIb/IIIa inhibitors and primary percutaneous coronary intervention in the multiple logistic regression model. Conclusion: The CENIC database was analyzed based on clinical, angiographic and procedure-related characteristics, as well as on clinical outcomes of percutaneous coronary interventions in patients with thrombus-containing lesions. Variables influencing inhospital mortality were initial period, elderly, female, absence of dyslipidemia and diabetes, previous acute myocardial infarction, more extensive coronary artery disease, use of glycoprotein IIb/IIIa inhibitors and primary percutaneous coronary intervention.