Clinical -anthropometric and laboratory parameters of newborns from mothers with impaired glucose metabolism

Klimov, Leonid; Alaverdyan, Lilit Samvelovna; Verisokina, Natalia; Kuryaninova, Victoria; Atanesyan, Roza; Zheleznyakova, T. V.; Попова, Е М; Bobryshev, Dmitry

doi:10.14300/mnnc.2018.13049

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…На более поздних сроках беременности (после завер шения органогенеза) гипергликемия у матери стимулирует гиперинсулинемию у плода и приводит к развитию ма кросомии, связываемой с гипертрофией βклеток под желудочной железы плода и гиперинсулинизмом в ответ на избыточное трансплацентарное поступление к плоду глюкозы матери [6,7]. Следует, отметить, что гипергли кемия матери, гиперинсулинизм плода и гормональная дисфункция плаценты приводят к отложению гликогена в миокарде с последующей его гипертрофией [8,9].…”

Section: обзор литературыunclassified

Diabetes mellitus during pregnancy — complications for the fetus and newborn

Gadzhieva,

Dikareva

2024

Journal of obstetrics and women's diseases

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Currently, diabetes mellitus is considered one of the most common problems in obstetrics and neonatology, associated with its high incidence and complications it causes — perinatal loss and morbidity of newborns, as well as further negative consequences for the child’s health. The incidence of diabetes mellitus is increasing in the world every year. According to forecasts of the International Diabetes Federation, there is no tendency to decrease the incidence in the near future. The increase in the incidence of diabetes mellitus is also due to a change in the criteria for diagnosis set out in the Gestational Diabetes Mellitus Treatment Guidelines. In addition, patients often do not understand the seriousness of the complications that occur with the disease, thereby not following the doctor’s treatment recommendations. To date, it has been proven that diabetes mellitus is a main cause of perinatal morbidity and mortality. According to the World Health Organization, even slight hyperglycemia in the mother during pregnancy is associated with the development of diabetic fetopathy. This article provides an analytical review of current literature covering the issues of perinatal and neonatal outcomes in the presence of diabetic fetopathy. Its characteristic phenotypic signs include macrosomia (due to increased fat deposition in subcutaneous tissue associated with increased production of somatotropic hormone) or microsomia (due to primary placental insufficiency), general pastiness, skin hyperemia, characteristic сushingoid-type appearance, body disproportion, puffy face in combination with other signs of immaturity, as well as transient hypertrophic cardiomyopathy and hepatosplenomegaly.

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Section: обзор литературыunclassified

Diabetes mellitus during pregnancy — complications for the fetus and newborn

Gadzhieva,

Dikareva

2024

Journal of obstetrics and women's diseases

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Vitamin D status and levels of pro-inflammatory cytokines in newborns born to mothers with endocrine diseases

Verisokina

Klimov²,

Захарова

et al. 2022

Medicinskij sovet

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Introduction. Vitamin deficiency states are found in 50–80% of pregnant women. Vitamin D deficiency is hazardous because it significantly increases the risk of complications during pregnancy, childbirth, as well as its effect on the child’s condition. Aim. To analyse the relationships between vitamin D status and levels of pro-inflammatory cytokines (IL-1β, IL-6) in children born to mothers with endocrine pathology.Materials and methods. Clinical-anthropometric and laboratory examination included 218 newborns: 98 (45.0%) infants of obese mothers, 32 (14.7%) infants of gestational diabetic mothers with underlying obesity, 22 (10.1%) infants of gestational diabetic mothers, 31 (14.2%) infants of mothers with type I diabetes mellitus and 35 (16.0%) infants of mothers without obesity and signs of impaired glucose tolerance.Results. Severe calcidiol deficiency is more often recorded in infants born to mothers with obesity, gestational diabetes mellitus and type I diabetes mellitus than in infants born to mothers without endocrine pathology. Serum IL-1β level was 2.6 times higher in newborns born to mothers with obesity than in the newborns from the control group — 14.6 (4.7; 36.5) and 5.6 (1.5; 13. 8) pg/ml, respectively (p = 0.04), 2.8 times higher in those born to women with gestational diabetes mellitus with underlying obesity —15.7 (6.5; 54.3) pg/ml (p = 0.02), 4.5 times higher in those born to mothers with gestational diabetes — 25.4 (5.0; 40.5) pg/ml (p = 0.035), and 6.1 times higher in those born to mothers with type I diabetes — 34.3 (3.8; 61.3) pg/ml (p = 0.01). Newborns born to mothers with type 1 diabetes mellitus had a higher serum IL-6 level as compared to the control group — 48.2 (21.3; 75.6) and 20.2 (5.1; 53.2) pg/ml (p = 0.006).Conclusion. Overweight and impaired glucose tolerance in the mother negatively affect the vitamin D sufficiency status, and if a fetus experiences vitamin D deficiency, provoke excessive production of pro-inflammatory cytokines in newborns.

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Vitamin D and proinflammatory cytokines in newborns from mothers with endocrine disorders

Захарова

Kuryaninova²,

Verisokina

et al. 2019

Tihookeanskij medicinskij žurnal

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Objective: The objective is a comparative analysis of vitamin D content and level of proinflammatory cytokines in infants born by mothers with endocrine disorders, and in infants of women with normal body weight.Methods: The clinic-anthropometrical and laboratory observation of 78 children born in Stavropol Regional Clinical Perinatal Centre: 36 infants were born by women with obesity and 18 – by women with gestational diabetes mellitus associated with obesity, 24 – by women who did not have obesity and clinical and laboratory signs of intolerance to glucose (control group). The level of calcidiol and interleukin 1β and 6 were determined in blood serum.Results: The content of vitamin D in infants born by healthy women was higher than in infants born by mothers with gestational diabetes mellitus associated with obesity and by mothers with obesity. Infants born by mothers with obesity had higher level of proinflammotary cytokines than those of control group.Conclusions: Children, born by mothers with endocrine disorders, have lower level of calcidiol and require postnatal prevention of vitamin D deficiency. Also it is necessary to take vitamin D during the pregnancy to prevent complications in pregnancy and neonatal pathology.

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Clinical -anthropometric and laboratory parameters of newborns from mothers with impaired glucose metabolism

Cited by 3 publications

References 9 publications

Diabetes mellitus during pregnancy — complications for the fetus and newborn

Diabetes mellitus during pregnancy — complications for the fetus and newborn

Vitamin D status and levels of pro-inflammatory cytokines in newborns born to mothers with endocrine diseases

Vitamin D and proinflammatory cytokines in newborns from mothers with endocrine disorders

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