Clinical, anthropometric, biochemical, and histological characteristics of nonobese nonalcoholic fatty liver disease patients of Bangladesh

Alam, Shahinul; Gupta, U; Alam, Mahbubul; Kabir, J.; Chowdhury, Ziaur Rahman; Alam, Afroja

doi:10.1007/s12664-014-0488-5

Cited by 67 publications

(109 citation statements)

References 39 publications

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“…[15]. This also agree with Alam et al, 2014 who found NASH in 53% of lean weighted patients with NAFLD [16]. Our study shows that the mean HOMA IR value in non-obese patients wasn't significantly lower than that in obese patients.…”

Section: Discussionsupporting

confidence: 92%

Role of Endotoxin and TNF in Developing NAFLD in Non-Obese Egyptian Patients

Mostafa¹,

Farag²,

Metwally³

et al. 2017

JBM

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Background and aim of the work: Non-alcoholic fatty liver disease (NAFLD) was considered the hepatic presentation of insulin resistance and obesity for a long time. Studies on lean weighted Asian subjects with NAFLD revealed that NAFLD pathogenesis may be multifactorial. NAFLD is associated with disturbances in gut flora and excess expression of inflammatory mediators. This study aims to find out the relation of endotoxins absorbed from gut and the tumor necrosis factor alpha with NAFLD in non-obese Egyptian patient in comparison to obese patients and healthy control subjects. Patients and methods: This study was performed on three groups group I: Patients with NAFLD and body mass index <25 kg/m 2 . Group II: Patients with NAFLD and body mass index >25 kg/m 2 . Group III: healthy control subjects. Results:Group I had significantly higher endotoxin, tumor necrosis factor(TNF) alpha and ALT than group II (endotoxin 11.7 ± 1.7 ug/L vs 9.5 ± 1.4)

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Section: Discussionsupporting

confidence: 92%

Role of Endotoxin and TNF in Developing NAFLD in Non-Obese Egyptian Patients

Mostafa¹,

Farag²,

Metwally³

et al. 2017

JBM

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“…Males were predominant in the non-obese, whereas females in the obese. NASH and fibrosis were similar in the obese and non-obese [45]. The prevalence of NASH is high.…”

Section: Current Research Work's Findings On Nafld In Bangladesh-naflmentioning

confidence: 73%

“…It does not mean that only obese people are at risk of NAFLD, study showed that, among NAFLD patients of Bangladesh 25.6% was non-obese, and 53.1 % of nonobese NAFLD cases had nonalcoholic steatohepatitis (NASH) [45]. Though they were not obese by BMI grade, they were metabolically similar to obese.…”

Section: Current Research Work's Findings On Nafld In Bangladesh-naflmentioning

confidence: 99%

“…Biopsy is recommended in NAFLD patients who have diabetes/ metabolic syndrome and elevated ALT, serum gamma-glutamyl transpeptidase (GGT) [41]. NASH of 40% in NAFLD patients of Bangladesh are in great danger to progress to cirrhosis and hepatocellular carcinoma in next 5 to 10 years [45]. These high number of NASH warrants attention of health policy makers to address the magnitude of the problem.…”

Section: Current Research Work's Findings On Nafld In Bangladesh-naflmentioning

confidence: 99%

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Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Alam¹

2017

GHOA

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Chronic hepatitis B (HBV) is one of the major diseases of mankind, estimated to cause about 686,000 deaths per year mostly from liver cancer and cirrhosis. And globally about 240 million people are chronically infected with hepatitis B. Nonalcoholic fatty liver disease (NAFLD) is an emerging commonest cause of chronic liver disease in the world. We have searched for CHB, NAFLD in PUBMED, Google scholar and local journals and related available articles were included in this review. Along with 184 countries of the world Bangladesh adopted hepatitis B vaccine in his EPI (expanded program on immunization) schedule for its prevention. And now about 95% of children are under cover of Hepatitis vaccine. Along with globally in last two decades' seroprevalence of HBsAg reduced about four times in Bangladesh. The prevalence of recorded nonalcoholic fatty liver disease (NAFLD) varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. The prevalence of NAFLD in Bangladesh is vary from 4%-18.4% and it is increasing day by day. About 40% of them are nonalcoholic steatohepatitis (NASH). They are in danger of progression to cirrhosis and hepatocellular carcinoma (15-19%) in next 5 to 10 years. Now it's becoming a silent killer for our nation. Gradual development of affluence, sedentary life style and increasing prevalence of diabetes contributed behind it. No effective treatment is available till now. Life style change by diet, exercise and weight reduction is the main stay of treatment. NAFLD involve multiple organs that leads to death due to cardiac, neurological and liver disease. Government and health department should take multidisciplinary action programs in awareness building and make a national guideline for fatty liver management.

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“…Male are largely dominating in nonobese group, where female are in obese group [36]. High BMI, central obesity, triglyceridemia and age are important risk factors for Bangladeshi people, and risk factors contributed about 29% risk for the occurrence of NASH [37].…”

Section: Depiction Of the Magnitude Among Different Risk Groupmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease: The Future Frontier of Hepatology for South Asia

Alam¹,

Lama²,

Mustafa³

et al. 2018

Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment

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This review is to know the magnitude of nonalcoholic fatty liver disease (NAFLD) among general population and risk group populations of the South Asian countries. A thorough search of evidence-based literature was conducted using the PubMed database with key words. Databases searched from inception to February 2017. Systematic search of the literature was conducted for studies pertaining. Prevalence of NAFLD in South Asia varies from 13 to 34%. The Highest rate is in Bangladesh (34.34%) and lowest in Pakistan (13.5%). Prevalence of NAFLD is 15-80% among obese people, 25-60% with dyslipidemia and 33-55% in pre diabetics and diabetics. Nonalcoholic steatohepatitis (NASH) is present in about 50% of the NAFLD cases that can lead to fibrosis, cirrhosis or even hepatocellular carcinoma (HCC). NAFLD is not the disease for only obese people, but it is also common in nonobese in this region. About 11.11% hepatocellular carcinoma developed from NASH. Incidence rate of diabetes and coronary artery disease is high among NAFLD patients. NAFLD is becoming a future challenge for South Asia region. Prevalence and severity has been remarkably increasing for last few years. The health system should get ready to confront burden of NAFLD in future for South Asia.

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Clinical, anthropometric, biochemical, and histological characteristics of nonobese nonalcoholic fatty liver disease patients of Bangladesh

Cited by 67 publications

References 39 publications

Role of Endotoxin and TNF in Developing NAFLD in Non-Obese Egyptian Patients

Role of Endotoxin and TNF in Developing NAFLD in Non-Obese Egyptian Patients

Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Nonalcoholic Fatty Liver Disease: The Future Frontier of Hepatology for South Asia

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