Clinical Application of Artificial Dermis and Autologous Skin in Repairing Skin and Soft Tissue Defects of Hands and Feet with Bone Exposure Injuries

Abstract

Patients with skin and soft tissue defects are very common. Mild trauma often causes mild skin damage, while severe injuries are often accompanied by bone and tendon exposure, which brings great pain to patients. For the defect of skin and soft tissue, the traditional treatment methods are mostly medium or full-thickness skin or skin flap transplantation. These methods are effective in wound repair, but there are still many problems. In recent years, with the improvement of tissue engineering technology, the use of artificial skin to repair various skin wounds is gradually becoming clinical, and the key technology of skin tissue engineering lies in the development of dermal substitutes. The appearance of artificial dermis not only solves the shortage of autologous skin source but also makes the operation simple and easy. The purpose of this study was to investigate the clinical effect of artificial dermis combined with autologous skin grafts in repairing hand and foot skin and soft tissue defects with bone exposure. The results show that the use of artificial dermis combined with autogenous blade thick skin to treat patients with hand and foot soft tissue injury with bone exposure has a good clinical effect, and the skin is alive and has fewer complications, which is worthy of promotion.

Comparison of Wound Healing Effect of Skin Micrograft Impregnated into Two Kinds of Artificial Dermis in a Murine Wound Model

“…Various soft tissue defects can be satisfactorily treated using artificial dermis. [2][3][4] However, it takes 2-3 weeks from applying artificial dermis to the wounds until sufficient granulation tissue is ready for skin grafting. This delay results in various complications, such as surgical site infections, particularly in the treatment of chronic skin ulcers.…”

Cortical perforation combined with Masquelet technique to treat extensive bone and soft tissue injury: A case report

“…Simultaneously, the induced membrane capsule not only distributes small blood vessels in the long axis direction but can also secrete vascular endothelial growth factor, transforming growth factor-beta 1, and bone morphogenetic protein-2 to promote local blood vessel formation. [ 12 , 13 ] However, no cases have been reported of direct coating of the bone with antibiotic-containing bone cement to form fresh induced membranes. In our patient, after the drilling, bone cement covered the bone surface.…”

Superficial Circumflex Iliac Artery Perforator Flap with Bilobed Design for the Donor Defect after Wrap‐Around Flap Transfer Reconstruction

“…Artificial dermis combined with VSD has also been used to repair the donor site of the great toe, but it is only suitable for repairing small area defects, not large ones 9 . Li et al used artificial dermis combined with autogenous blade thick skin to repair hand and foot skin and soft tissue, but the artificial dermis is susceptible to infection, which is not conducive to wound recovery, and there are still many limitations 10 . Many scholars further use the pedicled island flap to repair the toe donor area.…”

“… 9 Li et al used artificial dermis combined with autogenous blade thick skin to repair hand and foot skin and soft tissue, but the artificial dermis is susceptible to infection, which is not conducive to wound recovery, and there are still many limitations. 10 Many scholars further use the pedicled island flap to repair the toe donor area. According to reports, Özay Özkaya et al achieved satisfactory results in repairing the defect of the big toe with the first dorsal metatarsal artery island flap.…”