Clinical application of breath analysis for dimethyl sulfide following ingestion of dl-methionine

Kaji, Hiroshi; Hisamura, Masaya; Saito, Nariyoshi; Sakai, Hiroshi; Aikawa, Tadao; Kondo, Takahito; Ide, Hajime; Murao, Makoto

doi:10.1016/0009-8981(79)90288-2

Cited by 16 publications

(15 citation statements)

References 7 publications

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“…Increased levels of these compounds have been reported, already many years ago, during liver function impairment [9][10][11]. DMS has been implicated as the primary cause of fetor hepaticus, the typical smell of the breath present in some liver patients [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Early studies identified methyl mercaptan (MM) and dimethyl sulphide (DMS) as present in the breath of cirrhotic patients in hepatic coma [9]. Subsequently, the research groups of Kaji [10,11] and Tangerman [12,13] used improved gas chromatographic methods to demonstrate that the levels of all of these sulphur containing molecules were elevated in the breath of patients with cirrhosis even outside liver coma. More recently, in a preliminary study of breath biomarkers in liver diseases, Sehnert and coworkers reported that isoprene, carbonyl sulphide and carbonyl disulphide concentrations were significant different from the values in normal subjects [14].…”

Section: Introductionmentioning

confidence: 99%

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Breath biomarkers of liver cirrhosis

Dadamio

Velde

Laleman

et al. 2012

Journal of Chromatography B

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The diagnosis of asymptomatic cirrhosis in patients with liver disease is of importance to start screening for complications in due time. Liver biopsy is neither sensitive nor practical enough to be used as a frequent follow-up test in patients with chronic liver disease. The volatile organic compounds present in exhaled breath offer the possibility of exploring internal physiologic and pathologic process in a non invasive way. This study examined whether a specific pattern of biomarkers can be found in breath samples of patients with cirrhosis. To this aim samples of alveolar breath from patients with cirrhosis and healthy volunteers were analyzed using gas chromatography-mass spectrometry. When linear discriminant analysis was used to search for a model(s)/pattern of compounds characteristic for liver cirrhosis, 24 models of 8 independent compounds could distinguish between the groups. The sensitivity and specificity (between 82% and 88%, and 96% and 100%, respectively) of the models suggest that a specific pattern of breath biomarkers can be found in patients with cirrhosis, which may allow detecting this complication of chronic liver disease in an early stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breath biomarkers of liver cirrhosis

Dadamio

Velde

Laleman

et al. 2012

Journal of Chromatography B

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“…Breath of healthy individuals contains trace amounts of VSCs. Their increased concentrations (low ppbs) are attributed to impaired liver functions [7][8][9][10][11][12], halitosis [13][14][15][16], organ rejection after lung transplantation [17], lung cancer [18], cystic fibrosis [19], or schizophrenia [20].…”

Section: Introductionmentioning

confidence: 99%

Suitability of different polymer bags for storage of volatile sulphur compounds relevant to breath analysis

Mochalski

Wzorek

Śliwka

et al. 2009

Journal of Chromatography B

123

121

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“…Increased concentrations of VSCs were found in breath of individuals with impaired liver functions (carbonyl sulphide (COS), dimethyl sulphide (DMS), methanethiol (MeSH), ethanethiol (EtSH), dimethyl disulphide (DMDS), carbon disulphide (CS 2 ) [5][6][7], halitosis (H 2 S, MeSH, DMS, CS 2 ) [8][9][10][11], organ rejection after lung transplantation (COS) [12], lung cancer (DMS) [13], or schizophrenia (CS 2 ) [14].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, they are in most cases impractical due to some technical problems (PFPD, SCD), or high cost (AED). FPD is a stable, relatively inexpensive sulphur-selective detector, which has been employed in trace analyses of VSCs in different matrices [6,7,12,21,[24][25][26]. This detector together with a universal mass selective detector (MSD) found a wide application in VSCs analysis in human breath.…”

Section: Introductionmentioning

confidence: 99%