Clinical application of collagen sheet, YCWM, as a burn wound dressing

Yang, Jui-Yung

doi:10.1016/0305-4179(90)90077-a

Cited by 12 publications

(4 citation statements)

References 18 publications

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“…For that reason, collagen is often considered an optimal dressing for wound care. 4,[6][7][8][9] Proliferation of bacteria in wounds can be reduced naturally by phagocytosis or other immune processes. However, a topical antimicrobial treatment of infected chronic wounds may be necessary in immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%

A new anti-infective collagen dressing containing antibiotics

Grzybowski

Kolodziej²,

Trafny

et al. 1997

J. Biomed. Mater. Res.

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A new antibacterial dressing for infected wounds was prepared. The dressing was composed of a collagen membrane and collagen sponge; both biomaterials possess good tissue biocompatibility. An active antibacterial layer of limited hydrophobicity was placed between the membrane and the sponge and into the upper part of the sponge. The dressing contained gentamycin or amikacin at concentrations of 0.3 microgram/cm2 (loading level of the drug utilized during preparation of the dressing). Either the antibiotic or its concentration easily can be changed in the dressing by the manufacturer. The dressing was stable for several months. The antibiotic was released slowly from the dressing in in vitro experiments for 3 days. Antibacterial activity of the dressing was tested using a mouse wound model experimentally infected with Pseudomonas aeruginosa. Both dressings, containing either amikacin or gentamycin, reduced the number of living bacterial cells in the infected tissue almost to zero during the course of observation. The new dressing may be effective in the treatment of infected wounds in patients.

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Section: Introductionmentioning

confidence: 99%

A new anti-infective collagen dressing containing antibiotics

Grzybowski

Kolodziej²,

Trafny

et al. 1997

J. Biomed. Mater. Res.

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“…can be made into medical dressings that promote wound healing and increase suitability. [13][14][15] YANG prepared a young collagenous wettable membrane (YCWM), 16 which has been proven by clinical trials to be effective in relieving pain and has a certain therapeutic effect on burns and wounds in the donor area. Collagen-hyaluronic acid hydrogel helps with water retention, gas exchange, nutrient penetration, and cell growth.…”

mentioning

confidence: 99%

Preparation and comparison of two medical dressings made from the collagens from fish and bovine

Sun¹,

Wei²,

Wang³

et al. 2023

J Biomed Mater Res

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Collagen is used in medical dressings because of its high hydrophilicity, low immunogenicity, excellent biocompatibility, and degradability. These features can promote cell proliferation and platelet agglomeration. Herein, we studied the preparation of gel dressing by using silver carp skin collagen and bovine collagen as raw materials. Their properties and the application effects of collagen gel dressing were evaluated and compared. The centrifugal stability, rheology, and water‐loss rate of silver carp skin collagen gel (SCG) and bovine tendon collagen gel (CTG) were determined. Results showed that the two gels were stable, and SCG had better rheology and ductility than CTG. However, the denaturation temperature and water‐retention rate of SCG were slightly lower than those of CTG. Two collagen gels were used in the burn‐repair experiment of KM mice. Results showed that the SCG and CTG were consistent with the wound‐repair effect of commercially available products for shallow II‐degree scald and deep II‐degree scald. In the superficial shallow II scald experiment, SCG had a faster healing rate in the first 8 days and a shorter recovery time than CTG. In the deep II‐degree scald experiment, the wound‐healing rate of SCG on the 14th day reached 94.24%, which was 2 days faster than the recovery time of CTG. Moreover, the skin after wound healing was shallower than the scar produced after CTG treatment. Therefore, SCG had the potential to be used as the medical dressing.

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“…Biological dressings include untreated biological materials and chemically treated ones. Sterilized lyophilized porcine skin and dermis (2–5), collagen membrane prepared from biomaterials (6, 7), calcium sodium alginate from seaweeds (8, 9), and the recently developed collagen‐algimate dressing (10, 11) have been developed as biological dressings. A polyethylene film has also been found to provide good connective tissue regeneration and tissue growth (12).…”

mentioning

confidence: 99%

Promotive Effects of a Silk Film on Epidermal Recovery from Full‐Thickness Skin Wounds

Sugihara

Sugiura²,

Morita³

et al. 2000

Proc Soc Exp Biol Med

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Abstract. We examined the effects of the transparent fibroin film (silk film) on full‐thickness skin wounds. Full‐thickness dermatotomies (15 mm × 9 mm) were prepared on the dorsal wall of CRJ:CD‐1 nu/nu (ICR nu/nu) mice. The area of the wounds dressed with silk film was reduced to 10% of that made by the dermatotomy 14 days after the dermatotomy and were covered with regenerated epidermis 21 days after the dermatotomy. In contrast, less recovery and epidermal regeneration were found 14 days after dermatotomy in the wounds dressed with a conventional hydrocolloid dressing (Duro Active). Furthermore, only partial incomplete epidemal growth was obtained 21 days after dermatotomy. Most importantly, the healing time of wounds dressed with silk film was 7 days shorter than those dressed with DuoActive dressing. The silk film showed an almost similar or slightly better promotive effect as the lyophilized porcine dermis (Alloask D), which is used as a dressing for burns, ulcers, and decubitis. Histologic findings revealed that there was greater collagen regeneration and less inflammation and neutrophil‐lymphocyte infiltration of the wounds dressed with silk film than with DuoActive dressing. It is clear that regeneration of the epidermis and dermis of the wound beds covered with silk film was faster than with DuoActive dressing. Finally, silk film is easily obtainable, sterilizable, and transparent, and it allows easy observation of tissue recovery. Therefore, silk film offers advantages over other dressings and may be clinically useful for wound treatment.

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Clinical application of collagen sheet, YCWM, as a burn wound dressing

Cited by 12 publications

References 18 publications

A new anti-infective collagen dressing containing antibiotics

A new anti-infective collagen dressing containing antibiotics

Preparation and comparison of two medical dressings made from the collagens from fish and bovine

Promotive Effects of a Silk Film on Epidermal Recovery from Full‐Thickness Skin Wounds

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