Clinical Application of Dietary Therapies in Irritable Bowel Syndrome

Rej, Anupam; Avery, Amanda; Ford, Alexander C; Holdoway, Anne; Kurien, Matthew; McKenzie, Yvonne; Thompson, Julie; Trott, Nick; Whelan, Kevin; Williams, M. J.; Sanders, David S.

doi:10.15403/jgld.2014.1121.273.avy

Cited by 27 publications

(21 citation statements)

References 70 publications

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“…This was also observed in three other meta-analyses that including larger studies than ours. The inconsistency in the microbial profiles in the stools may be due to complicated and various factors among studies, for instance, individual experimental design (Sample storage, DNA extraction technique, 16S rRNA target region) (Lozupone et al, 2013;Mancabelli et al, 2017), host-related covariates (diet, antibiotics, inflammation, age, geography, temporal, culture, and race) (Wu et al, 2011;Yatsunenko et al, 2012;Gorvitovskaia et al, 2016;Staudacher and Whelan, 2016;Rej et al, 2018;Zhong et al, 2019), and disease assessment. Erysipelatoclostridium has been reported to be positively associated with dairy intake (Shen et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Leveraging 16S rRNA Microbiome Sequencing Data to Identify Bacterial Signatures for Irritable Bowel Syndrome

Liu

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain or discomfort. Previous studies have illustrated that the gut microbiota might play a critical role in IBS, but the conclusions of these studies, based on various methods, were almost impossible to compare, and reproducible microorganism signatures were still in question. To cope with this problem, previously published 16S rRNA gene sequencing data from 439 fecal samples, including 253 IBS samples and 186 control samples, were collected and processed with a uniform bioinformatic pipeline. Although we found no significant differences in community structures between IBS and healthy controls at the amplicon sequence variants (ASV) level, machine learning (ML) approaches enabled us to discriminate IBS from healthy controls at genus level. Linear discriminant analysis effect size (LEfSe) analysis was subsequently used to seek out 97 biomarkers across all studies. Then, we quantified the standardized mean difference (SMDs) for all significant genera identified by LEfSe and ML approaches. Pooled results showed that the SMDs of nine genera had statistical significance, in which the abundance of Lachnoclostridium, Dorea, Erysipelatoclostridium, Prevotella 9, and Clostridium sensu stricto 1 in IBS were higher, while the dominant abundance genera of healthy controls were Ruminococcaceae UCG-005, Holdemanella, Coprococcus 2, and Eubacterium coprostanoligenes group. In summary, based on six published studies, this study identified nine new microbiome biomarkers of IBS, which might be a basis for understanding the key gut microbes associated with IBS, and could be used as potential targets for microbiome-based diagnostics and therapeutics.

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Section: Discussionmentioning

confidence: 99%

Leveraging 16S rRNA Microbiome Sequencing Data to Identify Bacterial Signatures for Irritable Bowel Syndrome

Liu

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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“…The last few years has seen a rapid growth in the number of RCTs evaluating the efficacy of a low FODMAP diet in IBS, as highlighted in Table . These studies evaluated the short‐term elimination phase and demonstrate a response rate to a low FODMAP diet to be between 50 to 76 percent . Systematic reviews have raised concerns of a high risk of bias from these trials, in particular with regards to lack of blinding and the choice of control groups .…”

Section: Low Fodmap Dietmentioning

confidence: 99%

The role of diet in irritable bowel syndrome: implications for dietary advice

et al. 2019

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“…A. Rej и соавт. представлен ряд РКИ, демонстрирующих преимущества строгой БГД у больных СРК в сравнении с плацебо и возобновление симптомов кишечной дис-пепсии при ее нарушении [41]. Работа J. Biesiekierski и соавт.…”

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Diet therapy for irritable bowel syndrome

Бакулин

Авалуева

Орешко

et al. 2020

Terapevticheskii arkhiv

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The review provides present information on the pathogenesis of irritable bowel syndrome (IBS), the relationship of endogenous and exogenous factors with the development of IBS-symptoms, questions of diet therapy are discussed, diets traditionally prescribed in IBS treatment and diets, such as FODMAP and gluten-free diet, which are the most promising and have a positive effect on the symptoms of IBS.

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Clinical Application of Dietary Therapies in Irritable Bowel Syndrome

Cited by 27 publications

References 70 publications

Leveraging 16S rRNA Microbiome Sequencing Data to Identify Bacterial Signatures for Irritable Bowel Syndrome

Leveraging 16S rRNA Microbiome Sequencing Data to Identify Bacterial Signatures for Irritable Bowel Syndrome

The role of diet in irritable bowel syndrome: implications for dietary advice

Diet therapy for irritable bowel syndrome

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