Clinical application of double plasma molecular adsorption system in treatment of acute liver failure

Severe acute hepatitis of unknown causes in children – Current findings, questions, opinions, and recommendations, a mini‐review

“…On the other hand, some of the alternative treatments like extracorporeal biological and non-biological liver support methods, plasmapheresis, and blood-purification treatments have achieved preliminary results showing that some of such treatments could be effective and safe. [26][27][28] (3) Treatment of disseminated intravascular coagulation (DIC): Patients with severe liver injury and massive hepatocyte necrosis may progress into liver failure and multiorgan failure and may develop DIC, which at the early stage may have hypercoagulation status, which needs quick and appropriate heparin treatment, and at the later stage, widespread fibrinolysis would occur, and at this stage anti-fibrinolytic treatment with aminocaproic acid may be needed. 29,30 (4) Possibility of conducting randomized controlled clinical trials: If the number of SAHUC cases continues to increase, it should be possible to design and conduct prospective randomized controlled clinical trials focusing on different therapeutic approaches, for example, antiviral therapy with cidofovir, for instance, if a study team considers it is required and worthy of testing and approved.…”

“…10,11 By May 11, 450 probable cases were reported worldwide, 31 required liver transplantation, and 11 cases died. 12 The countries that reported more than 10 cases include the UK (197), the US (180), Brazil (44), Italy (35), Spain (26), Mexico (21), Indonesia (14), Israel (12), Japan (12), Portugal (12), and Canada (11). 11,13 There were no clusters in rural or urban areas, no relation with parents' occupation, and so forth.…”