Clinical Application of Image-guided Radiotherapy in Bladder and Prostate Cancer

Button, M.; Staffurth, John

doi:10.1016/j.clon.2010.06.020

Cited by 54 publications

(55 citation statements)

References 111 publications

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“…Similar to prostate radiotherapy patients, this work demonstrates that rectal filling impacts on bladder positioning [10,9]. Intervention such as the use of daily enemas may result in more consistent positioning in these patients [20].…”

Section: Population Bladder Organ Motion Errorsmentioning

confidence: 91%

“…IGRT was performed using a kV CBCT system (XVI, Version 4.2 (2007Version 4.2 ( -2010, Elekta AB, Stockholm, Sweden) equipped on a linear accelerator (Elekta Synergy (2007-2010, Elekta AB, Stockholm, Sweden). CBCTs were acquired on the day before the first treatment delivery day, to verify positioning and readiness prior to treatment, and on the first two treatment days.…”

Section: Treatment Verification With Igrtmentioning

confidence: 99%

“…Volumetric bladder imaging using cone beam CT provides images of ample quality for use in IGRT [9,10]. The National Radiotherapy Implementation Group (NRIG) published guidelines for IGRT implementation and use in 2012 [11].…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the need for adaptive therapy when delivering conformal bladder radiotherapy

et al. 2016

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Section: Population Bladder Organ Motion Errorsmentioning

confidence: 91%

Section: Treatment Verification With Igrtmentioning

confidence: 99%

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Evaluating the need for adaptive therapy when delivering conformal bladder radiotherapy

et al. 2016

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“…Three volumes are usually drawn: the GTV (gross tumour volume) consists of the actual tumour that is then extended with a margin for microscopic spread to create the CTV (clinical target volume). 3 The CTV often also includes nodal areas at risk. A further margin is added to the CTV to allow for potential daily variation in tumour position, which can be from patient positioning or from internal organ motion.…”

Section: Immobilization Imaging and Target Volume Definitionmentioning

confidence: 99%

Principles of cancer treatment by radiotherapy

Owadally

Staffurth

2015

Surgery (Oxford)

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“…However, this is likely to be a suboptimal approach, leading to unnecessarily high doses to normal tissue where bladder volume remains small, while failing to achieve target coverage for patients who encounter increasing bladder volume throughout treatment [7]. Henry et al [8] found that 26% of bladder patients monitored using cone beam CT (CBCT) required replanning owing to increasing bladder volume (53%), decreasing bladder volume (38%) and decreasing rectal volume (9%).…”

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confidence: 99%

Comparison of adaptive radiotherapy techniques for the treatment of bladder cancer

Webster

Stratford

Rodgers

et al. 2013

BJR

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Objective: Day-to-day anatomical variations complicate bladder cancer radiotherapy treatment. This work quantifies the impact on target coverage and irradiated normal tissue volume for different adaptive strategies. Methods: 20 patients were retrospectively planned using different three-dimensional conformal radiotherapy treatment strategies for whole-bladder carcinoma: (i) ''conventional'' treatment used isotropic expansion of the clinical target volume (CTV) by 15 mm to the planning target volume (PTV) for daily treatment; (ii) ''plan of the day'' used daily volumetric on-treatment imaging [cone beam CT (CBCT)] to select from four available plans with varying superior PTV margins; (iii) ''composite'' strategies used ontreatment CBCTs from Fractions 1-3 to inform a composite CTV and adapted PTV (5-and 10-mm margins for composite 1 and composite 2, respectively) for subsequent treatment. Target coverage was evaluated from available CBCTs (the first three fractions then the minimum weekly thereafter), and the reduction in the irradiated volume (i.e. within the 95% isodose) was quantified. Results: Plan of the day improved target coverage (i.e. all of the bladder within the 95% isodose throughout the treatment) relative to conventional treatment (p50.10), while no such benefit was observed with composite 2. Target coverage was reduced with composite 1 relative to conventional treatment. The mean irradiated volume was reduced by 17.2%, 35.0% and 14.6% relative to conventional treatment, for plan of the day, composite 1 and composite 2, respectively (p,0.01 in all cases). No parameters predictive of large changes in bladder volume later in the treatment were identified. Conclusions: Adaptive techniques can maintain or improve target coverage while allowing for reduced irradiated volume and possibly reduced toxicity. The plan-of-theday technique appeared to provide the optimal balance between target coverage and normal tissue sparing. Advances in knowledge: This study suggests that plan-of-the-day techniques will provide optimal outcomes for adaptive bladder radiotherapy.

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Clinical Application of Image-guided Radiotherapy in Bladder and Prostate Cancer

Cited by 54 publications

References 111 publications

Evaluating the need for adaptive therapy when delivering conformal bladder radiotherapy

Evaluating the need for adaptive therapy when delivering conformal bladder radiotherapy

Principles of cancer treatment by radiotherapy

Comparison of adaptive radiotherapy techniques for the treatment of bladder cancer

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