Clinical application of near-infrared spectroscopy in patients with traumatic brain injury: a review of the progress of the field

Sen, Anish; Gopinath, Shankar P.; Robertson, Claudia S.

doi:10.1117/1.nph.3.3.031409

Cited by 53 publications

(29 citation statements)

References 32 publications

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“…Numerous applications of NIRS technology in the assessment of brain function under various clinical conditions caused by traumatic brain injury (TBI) or stroke indicate the importance of study and evaluation of light tissue interaction under such conditions . Applying various types of clinically relevant changes in the brain such as intracranial hematoma development on a digital model could effectively help in predicting the photon path during measurements with a NIRS device, improving the diagnosis of brain injury.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications

Wang

Ayaz

İzzetoğlu

2019

Journal of Biophotonics

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Understanding near infrared light propagation in tissue is vital for designing next generation optical brain imaging devices. Monte Carlo (MC) simulations provide a controlled mechanism to characterize and evaluate contributions of diverse near infrared spectroscopy (NIRS) sensor configurations and parameters. In this study, we developed a multilayer adult digital head model under both healthy and clinical settings and assessed light‐tissue interaction through MC simulations in terms of partial differential pathlength, mean total optical pathlength, diffuse reflectance, detector light intensity and spatial sensitivity profile of optical measurements. The model incorporated four layers: scalp, skull, cerebrospinal‐fluid and cerebral cortex with and without a customizable lesion for modeling hematoma of different sizes and depths. The effect of source‐detector separation (SDS) on optical measurements' sensitivity to brain tissue was investigated. Results from 1330 separate simulations [(4 lesion volumes × 4 lesion depths for clinical +3 healthy settings) × 7 SDS × 10 simulation = 1330)] each with 100 million photons indicated that selection of SDS is critical to acquire optimal measurements from the brain and recommended SDS to be 25 to 35 mm depending on the wavelengths to obtain optical monitoring of the adult brain function. The findings here can guide the design of future NIRS probes for functional neuroimaging and clinical diagnostic systems.

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Section: Introductionmentioning

confidence: 99%

Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications

Wang

Ayaz

İzzetoğlu

2019

Journal of Biophotonics

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“…Much progress of NIRS and DOT research in human head has been achieved. Accurate modeling of tissue increased the utility of photon migration for a broader range of applications including: cerebral metabolism , cerebral edema , traumatic brain injury , functional neuroimaging . However, the study on photon migration in human heart has not been thoroughly researched yet.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo modeling of photon migration in realistic human thoracic tissues for noninvasive monitoring of cardiac hemodynamics

Liu

Chen

Fang

et al. 2019

Journal of Biophotonics

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Noninvasive monitoring of cardiac hemodynamics remains challenging in cardiovascular medicine. The possibility of noninvasive optical monitoring of cardiac hemodynamics was theoretically investigated in this study. By utilizing the Monte Carlo simulation method for voxelized media (MCVM) and Visible Chinese Human dataset, we quantified and visualized the photon migration in human thoracic region. The light fluence distribution was showed to reach heart tissue (∼3 cm depth underbody surface) and 12% of the total fluence was absorbed by the myocardium. The proportion of spatial sensitivity distribution (SSD) in cardiac tissue to the total SSD reached 0.0195%. The portion of SSD increased following with cardiac diastole and diffuse reflectance deceased linearly with increasing cardiac volume. The optimal separation between the light source and detector was provided to be 3.5 to 4.0 cm for future development of noninvasive cardiac hemodynamics monitoring. A pilot experimental study was conducted to measure the diffuse reflectance light and fingertip photoplethysmography. These data suggest that the fluctuation period of near‐infrared (NIR) diffuse reflectance was consistent with the cardiac cycle, while the fluctuation features of the NIR signal was not consistent with that of photoplethysmography. All results indicate the great potential of noninvasive optical monitoring of myocardial hemodynamics.

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“…In recent years, the resolution of SPECT has gradually increased, which is getting closer to the PET. Near-infrared (NIR) fluorescence imaging system has been utilized in clinical practice for providing image-guided surgery, traumatic brain injury, and breast cancer detection [ 67 – 69 ], however, the limitations of tissue penetration and extra-cerebral contamination let it unable to visualize the deep tissue regions [ 68 , 70 ]. In general, it seems difficult to replace nuclear medicine imaging for cancer patients at present.…”

Section: Discussionmentioning

confidence: 99%

Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

Guan

Chiu

et al. 2018

J Transl Med

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BackgroundThe human epidermal growth factor receptor 2 (HER2) involved proliferation, angiogenesis, and reduced apoptosis in gastric cancer (GC), which is a common target for tumor therapy. HER2 is usually overexpressed in more than 15% GC patients, developing a reliable diagnostic tool for tumor HER2 detection is important. In this study, we attend to use polyethylene glycol (PEG) linked anti-HER2/neu peptide (AHNP-PEG) as a nuclear imaging agent probe for HER2 detection in GC xenograft animal model.MethodsThe HER2 expression of human sera and tissues were detected in GC patients and normal subjects. GC cell lines NCI-N87 (high HER2 levels) and MKN45 (low HER2 levels) were treated with AHNP-PEG to assess the cell viability and HER2 binding ability. The NCI-N87 was treated with AHNP-PEG to observe the level and phosphorylation of HER2. The MKN45 and NCI-N87-induced xenograft mice were intravenous injection with fluorescence labeled AHNP-PEG for detecting in vivo fluorescence imaging properties and biodistribution. The AHNP-PEG was conjugated with diethylenetriaminopentaacetic acid (DTPA) for indium-111 labeling (111In-DTPA-AHNP-PEG). The stability of was assessed in vitro. The imaging properties and biodistribution of 111In-DTPA-AHNP-PEG were observed in NCI-N87-induced xenograft mice.ResultsThe serum HER2 (sHER2) levels in GC patients were significantly higher than the normal subjects. The sHER2 levels were correlated with the tumor HER2 levels in different stages of GC patients. The AHNP-PEG inhibited the cell growth and down-regulated HER2 phosphorylation in HER2-overexpressed human GC cells (NCI-N87) via specific HER2 interaction of cell surface. In addition, the GC tumor tissues from HER2-postive xenograft mice presented higher HER2 fluorescence imaging as compared to HER2-negative group. The HER2 levels in the tumor tissues were also higher than other organs in NCI-N87-induced xenograft mice. Finally, we further observed that the 111In-DTPA-AHNP-PEG was significantly enhanced in tumor tissues of NCI-N87-induced xenograft mice compared to control.ConclusionsThese findings suggest that the sHER2 measurement may be as a potential tool for detecting HER2 expressions in GC patients. The radioisotope-labeled AHNP-PEG may be useful to apply in GC patients for HER2 nuclear medicine imaging.

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Clinical application of near-infrared spectroscopy in patients with traumatic brain injury: a review of the progress of the field

Cited by 53 publications

References 32 publications

Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications

Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications

Monte Carlo modeling of photon migration in realistic human thoracic tissues for noninvasive monitoring of cardiac hemodynamics

Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

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