Clinical application of oocyte vitrification: a systematic review and meta-analysis of randomized controlled trials

Cobo, Ana; Díaz, Carmen Pérez

doi:10.1016/j.fertnstert.2011.06.030

Cited by 366 publications

(196 citation statements)

References 35 publications

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“…But as cryopreservation techniques have been refined [8,9], more studies have reported improved outcomes after FET cycles when compared to fresh ET [7,14,15]. Traditionally, embryo cryopreservation was undertaken in patients with surplus embryos or patients with contraindications to transfer such as risk of OHSS or poor endometrial development and in some instances for fertility preservation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, with the advances and optimization made in cryopreservation methods [8], the quality of the frozen embryos and their reproductive potential are at least similar to those observed with fresh embryos [9]. Current techniques of cryopreservation are efficient, reliable, and documented as safe, and evidence is accumulating that freezing and rewarming embryos may result in outcomes equivalent if not superior to transfer in fresh cycles [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Rodriguez-Purata

Lee

Whitehouse

et al. 2016

J Assist Reprod Genet

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Purpose The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. Material and Methods This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from January 2011 to July 2015 were included. Patients were divided into three groups: "Fresh Only," "Frozen Embryo Transfer ('FET) Only," and "Fresh ET then FET." For "Fresh Only" group (n = 345), PGS results were received within 24 h. For "FET Only" group (n = 514), results were expected after 24 h, and embryos were cryopreserved after biopsy; only FET was performed in this group (no fresh transfer). For "FET with a previous fresh ET" (n = 139) group, patients underwent a fresh ET with a subsequent FET, in which the same cohort of embryos was utilized. The main outcome measures were pregnancy rate (PR), clinical PR, implantation rate (IR), LBR, and early pregnancy loss rate. Results IRs were statistically higher in the "FET Only" group when compared to the "Fresh Only" group (59.5 vs. 50.6 %, p < 0.01) and the "FET with a previous fresh ET" (59.5 vs. 50.6 %, p < 0.05). LBR was statistically significant in the "FET Only" group when compared to the "Fresh Only" group (57.6 vs. 46.5 %, p < 0.005) but not when compared to "FET with a previous fresh ET" group (57.6 vs. 47.7 %, p = 0.07). Conclusions This analysis suggests euploid embryos to be more likely to implant and achieve a LBR in a synthetic FET cycle than in a fresh cycle.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Rodriguez-Purata

Lee

Whitehouse

et al. 2016

J Assist Reprod Genet

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“…Alternatively, the option to cryopreserve oocytes instead of embryos might be a more realistic option for young women without a partner [45]. It can be considered a good choice in patients affected by endometriosis as it has no effect on future ovarian reserve and is less invasive than other FPT.…”

Section: Embryo/egg Freezingmentioning

confidence: 99%

The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presence of bilateral endometriomas. In many cases, enhanced loss of ovarian reserve may also result from the damaging effect of the pathologic process on follicle reservoir even without surgical interventions. Women diagnosed with severe endometriosis and those designated for extensive ovarian surgical intervention are frequently not planning to conceive. In light of recent advances in fertility preservation techniques (FPT), such as oocytes and ovarian tissue freezing, as well as their increasing success rates, we critically evaluate the options for FPT in patients suffering from endometriosis. Personalized counseling should be offered to all patients with endometriosis taking into account age, extent of ovarian involvement, current ovarian reserve, previous and impending surgeries for endometriosis, along with current success rates and possible risks associated with FPT.

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“…To date, several children have been born from women who conceived in vivo or in vitro after reimplantation of ovarian tissue [3]. Giving rise to very numerous births in IVF patients, oocyte cryopreservation has proven itself to be a productive approach [9], although its capability in cases of fertility preservation remains to be documented. However, a single methodology is not applicable to the diverse clinical and personal conditions of women in need of fertility preservation.…”

Section: Discussionmentioning

confidence: 99%

Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer

Fadini

Canto

Renzini

et al. 2012

J Assist Reprod Genet

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Clinical application of oocyte vitrification: a systematic review and meta-analysis of randomized controlled trials

Cited by 366 publications

References 35 publications

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

The role of fertility preservation in patients with endometriosis

Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer

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