Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

Guan, Shuai; Xiao, Tiepeng; Bai, Jiuping; Ning, Chunliu; Zhang, Xingkui; Yang, Lei; Li, Xiangjun

doi:10.1016/j.heliyon.2023.e13196

Cited by 13 publications

(5 citation statements)

References 60 publications

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“…The authors recommended the use of PRF in conjunction with guided bone regeneration that can serve as a reliable and easy adjuvant for rapid implanting in diseased sockets [ 30 ]. Recent studies by Kapoor A et al [ 31 ] and Guan S et al [ 32 ] have concluded that PRF has a significant effect on osseointegration of dental implants during the early healing period prior to loading. Additionally, it has been found that PRF can be loaded with antibiotics to effectively release antimicrobial drugs that reduce the risk of post-operative infections.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of effect on stability of implants with and without platelet rich fibrin using a resonance frequency analyzer - An in-vivo study

Anapu,

Atluri,

Chandra Tripuraneni

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Evaluation of effect on stability of implants with and without platelet rich fibrin using a resonance frequency analyzer - An in-vivo study

Anapu,

Atluri,

Chandra Tripuraneni

et al. 2024

Heliyon

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“…Since the osteoinductive properties of growth factors such as BMPs and TGF-β in bone healing around the implant have been proven, and PRF is also a rich source of these growth factors, what we expect about the use of this material around the implant is increasing implant stability immediately after surgery, accelerating tissue healing and promoting the formation of new bone at the implant site [ 37 , 38 ]. Since accurate measurement of these parameters is just possible histologically by tissue samples, it would not be possible to definitively determine the type of healing, time, and process of osseointegration around the implant.…”

Section: Discussionmentioning

confidence: 99%

The effect of leukocyte- and platelet-rich fibrin on the bone loss and primary stability of implants placed in posterior maxilla: a randomized clinical trial

Naeimi Darestani,

Asl Roosta,

Mosaddad

et al. 2023

Int J Implant Dent

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Purpose In this study, we investigated the effects of leukocyte- and platelet-rich fibrin (L-PRF) on implant stability and alterations in the marginal bone surrounding posterior maxillary implants. Methods This randomized clinical trial was conducted to compare the variable of L-PRF placement around maxillary implants. Resonance frequency analysis (RFA) was used to evaluate the implant stability immediately after surgery and at 1, 2, 4, 6, 8, and 12 weeks after surgery (t0 to t6, respectively). In addition, the amount of marginal bone changes around the implant at t6 was compared with the baseline using periapical radiography. Results The RFA outcomes were statistically significant within each group (P < 0.001, Eta2 = 0.322); however, in none of the follow-ups and immediately after the surgery, there was a significant difference between the two groups in terms of the implant stability quotient (ISQ) scores (P > 0.05). At t0, the test and control groups' respective mean levels of marginal bone loss around the implants were 0.4836 mm and 0.7343 mm, significantly different from the corresponding values at t6. On the other hand, marginal bone loss around the implant was not significantly different between the two groups in t0 and t6 (P = 0.532). Conclusions L-PRF did not improve the RFA outcomes of implants three months after implant placement, and changes in the ISQ values over time were the same in both groups. In addition, L-PRF had no superior effect on the marginal bone loss around the implants. Trial registration number: The research was registered in the Iranian Registry of Clinical Trials on 22 December 2020 (No: IRCT20200624047906N1), available at http://www.irct.ir

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“…In the clinical field of dentistry, PRF has also been widely used in dental clinics, including oral implantology, periodontology, maxillofacial surgery and mucosal diseases 9–12 . However, most of the applications in these fields are still based on the research reports on the ability of PRF to promote tissue repair and regeneration in combination with other materials, and there are few reports on the clinical studies on PRF alone as a material to promote the repair and regeneration of soft tissue defects 13 . Although there have been some studies on the use of PRF for healing and pain in extraction wounds compared with natural healing, the conclusions are not yet uniform.…”

Section: Introductionmentioning

confidence: 99%

“… 9 , 10 , 11 , 12 However, most of the applications in these fields are still based on the research reports on the ability of PRF to promote tissue repair and regeneration in combination with other materials, and there are few reports on the clinical studies on PRF alone as a material to promote the repair and regeneration of soft tissue defects. 13 Although there have been some studies on the use of PRF for healing and pain in extraction wounds compared with natural healing, the conclusions are not yet uniform. Therefore, taking into account the current knowledge of PRF and clinical needs, this study intends to evaluate the effects of PRF compared with natural healing on post‐extraction wound healing and pain, with the aim of providing evidence‐based medical evidence for clinical options.…”

Section: Introductionmentioning

confidence: 99%

Effects of platelet‐rich fibrin on post‐extraction wound healing and wound pain: A meta‐analysis

Yuan,

Xu,

Yang

et al. 2024

International Wound Journal

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We conducted a meta‐analysis to assess the effect of platelet‐rich fibrin (PRF) on post‐extraction wound healing and pain, with a view to providing a reliable basis for the selection of treatment options in clinical practice. A computerised search of PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure and Wanfang databases for studies on the effect of PRF on post‐extraction wound healing and pain compared with natural healing (control group) was performed from the time of creation of the respective databases to July 2023. Literature screening, data extraction and quality assessment were done independently by two authors. Meta‐analysis was performed using RevMan 5.4 software. Fourteen studies with a total of 508 patients were finally included. Meta‐analysis showed that the use of PRF relieved patients' wound pain (standardised mean differences [SMDs]: −1.78, 95% confidence intervals [CIs]: −2.61 to −0.94, p < 0.001), promoted soft tissue healing of extraction wounds (SMD: 1.09, 95% CIs: 0.26–1.91, p = 0.010) and also reduced the incidence of alveolar osteitis (AO) in patients after tooth extraction (2.42% vs. 10.14%, odds ratio: 0.27, 95% CIs: 0.11–0.65, p = 0.004). Current clinical evidence suggests that the use of PRFs can reduce patients' postoperative wound pain, promote soft tissue healing of extraction wounds and reduce the incidence of postoperative AO compared with natural healing. However, due to limitations in the number and quality of studies, large‐scale randomised controlled trials are still needed to validate the results of this study in the future.

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Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

Cited by 13 publications

References 60 publications

Evaluation of effect on stability of implants with and without platelet rich fibrin using a resonance frequency analyzer - An in-vivo study

Evaluation of effect on stability of implants with and without platelet rich fibrin using a resonance frequency analyzer - An in-vivo study

The effect of leukocyte- and platelet-rich fibrin on the bone loss and primary stability of implants placed in posterior maxilla: a randomized clinical trial

Effects of platelet‐rich fibrin on post‐extraction wound healing and wound pain: A meta‐analysis

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