Clinical Application of Platelet-Rich Fibrin in Dermatology

Abstract

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate obtained from autologous blood. PRF is composed of abundant platelets, leucocytes, and a high concentration of various growth factors and fibrinogen. The composition and three-dimensional structure of PRF enable it to effectively make cells migrate and proliferate, playing an important role in tissue repair. Furthermore, the easy preparation and low cost of PRF make it a good treatment option. Numerous articles have been published about the application of PRF in clinical practice, however, the application of PRF in dermatology has not been comprehensively reviewed. The objective of this review article was to discuss various applications of PRF in dermatology, including healing chronic wounds, treating androgenic alopecia, skin rejuvenation, autologous fat transplantation, and treating vitiligo. PRF is a promising dermatologic treatment, but lacks a standardized protocol regarding its methods of attainment and use, which needs more investigations.

Revitalizing Your Skin: The Power of Microneedling with PRP for Pigmentation Reduction

“…Its ability to promote collagen production, minimize downtime, and offer long-lasting results makes it a compelling choice in the field of aesthetic dermatology. Further research and clinical trials are still needed to explore the optimal treatment protocols, long-term efficacy, and potential combination therapies for enhancing the outcomes of microneedling with PRP in pigmentation reduction (17,18). Footnotes Authors' Contribution: Study concept: Sadra Amirpour Haradasht.…”