Clinical Application of Platelet-Rich Fibrin in Pediatric Dentistry

Abstract

Platelet-rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. It can be obtained from blood with the help of a simple process. PRF is basically a concentrate of growth factors that promote wound healing and regeneration, which is used in various disciplines of dentistry to repair various lesions and regenerate dental and oral tissues. Although the use of PRF is well-documented, its use in pediatric dentistry remains unexplored, due to its restrictions and on account of the fact that it is a blood-derived product. PRF has been used globally to enhance tissue healing. This article provides an insight into the use of PRF in pediatric dentistry, its benefits, limitations, and recommendations.

What can we learn from treatments of oral lichen planus?

“…The PRF serves as a biodegradable scaffold for microangiogenesis and can direct epithelial cells to migrate to its surface ( Dohan et al., 2006 ; Li et al., 2013 ). The benefits of PRF over PRP include, but are not limited to, the fact that it does not require anticoagulants, promotes faster wound healing, and boosts the immune system ( Gunasekaran et al., 2021 ). In recent years, scholars have found PRF local injections to be comparable to tretinoin (TA) in relieving OLP pain, suggesting a role in EOLP pain control ( Bennardo et al., 2021 ).…”

Management of Failed Regenerative Endodontic Treatment of a Necrotic Immature Molar: A Case Report With 12-Month Follow Up

“…Furthermore, drawing blood from pediatric patients can be challenging due to their lack of compliance[34].As mentioned before, the main reason for failed regenerative endodontic cases is inadequate disinfection, inadequate biofilm removal, and the presence of preceding infection, which all lead to root canal reinfection[5].MTA is highly biocompatible [42,43], has good sealing…”