Clinical application of serum-based proteomics technology in human tumor research

Li, Chen; Xiao, Juan; Wu, Shanshan; Liu, Lu; Zeng, Xuemei; Zhao, Qiang; Zhang, Zhiwei

doi:10.1016/j.ab.2022.115031

Cited by 4 publications

(5 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum proteins associated with clinical metrics of interest include those associated with diagnostic, prognostic, and predictive therapeutic response in CC patients. Serum samples have historically been chosen as the standard for clinical chemistry tests versus plasma samples [47]. Serum samples differ from plasma samples in that cellular components are easily separated, they have greater stability, and they lack clotting factors which allows for an easier application of proteomic techniques for analysis [47].…”

Section: Serum Protein Markers In CCmentioning

confidence: 99%

Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions

Weaver,

Nam,

Settle

et al. 2024

Cancers

View full text Add to dashboard Cite

In 2020, the World Health Organization (WHO) reported 604,000 new diagnoses of cervical cancer (CC) worldwide, and over 300,000 CC-related fatalities. The vast majority of CC cases are caused by persistent human papillomavirus (HPV) infections. HPV-related CC incidence and mortality rates have declined worldwide because of increased HPV vaccination and CC screening with the Papanicolaou test (PAP test). Despite these significant improvements, developing countries face difficulty implementing these programs, while developed nations are challenged with identifying HPV-independent cases. Molecular and proteomic information obtained from blood or tumor samples have a strong potential to provide information on malignancy progression and response to therapy in CC. There is a large amount of published biomarker data related to CC available but the extensive validation required by the FDA approval for clinical use is lacking. The ability of researchers to use the big data obtained from clinical studies and to draw meaningful relationships from these data are two obstacles that must be overcome for implementation into clinical practice. We report on identified multimarker panels of serum proteomic studies in CC for the past 5 years, the potential for modern computational biology efforts, and the utilization of nationwide biobanks to bridge the gap between multivariate protein signature development and the prediction of clinically relevant CC patient outcomes.

show abstract

Section: Serum Protein Markers In CCmentioning

confidence: 99%

Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions

Weaver,

Nam,

Settle

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…Proteins play an essential role in every important component of organisms, and execute the functions encoded in the genome [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, changes in blood protein levels often reflect physiological and pathological conditions in vivo. Mass spectrometry (MS)-based quantitative proteomics using serum, which is the liquid fraction of whole blood, is therefore a rapidly advancing technique for addressing various challenges and identifying diagnostic markers [9]. Hence, a comprehensive proteomic analysis of the serum, including characterizing the body's response to gravity unloading, should help characterize gravity adaptation mechanisms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Kimura,

Nakai,

Ino

et al. 2024

Proteomics

View full text Add to dashboard Cite

Physical inactivity associated with gravity unloading, such as microgravity during spaceflight and hindlimb unloading (HU), can cause various physiological changes. In this study, we attempted to identify serum proteins whose levels fluctuated in response to gravity unloading. First, we quantitatively assessed changes in the serum proteome profiles of spaceflight mice using mass spectrometry with data‐independent acquisition. The serum levels of several proteins involved in the responses to estrogen and glucocorticoid, blood vessel maturation, osteoblast differentiation, and ossification were changed by microgravity exposure. Furthermore, a collective evaluation of serum proteomic data from spaceflight and HU mice identified 30 serum proteins, including Mmp2, Igfbp2, Tnc, Cdh5, and Pmel, whose levels varied to a similar extent in both gravity unloading models. These changes in serum levels could be involved in the physiological changes induced by gravity unloading. A collective evaluation of serum, femur, and soleus muscle proteome data of spaceflight mice also showed 24 serum proteins, including Igfbp5, Igfbp3, and Postn, whose levels could be associated with biological changes induced by microgravity. This study examined serum proteome profiles in response to gravity unloading, and may help deepen our understanding of microgravity adaptation mechanisms during prolonged spaceflight missions.

show abstract

“…Serum proteomics, as an emerging research technique in the field of biomedical research, involves the comprehensive analysis of proteins to identify biomarkers, understand disease mechanisms, and enhance disease diagnosis and prognosis. 12 , 13 In a study by Cheng et al 14 serum proteomics was employed utilizing high-resolution mass spectrometry analysis to construct a serum protein profile. They identified 18 proteins that were significantly overexpressed.…”

Section: Introductionmentioning

confidence: 99%

Serum proteomics identify CSF1R as a novel biomarker for postoperative recurrence in chronic rhinosinusitis with nasal polyps

Niu,

Cao,

Luo

et al. 2024

World Allergy Organization Journal

View full text Add to dashboard Cite

Clinical application of serum-based proteomics technology in human tumor research

Cited by 4 publications

References 188 publications

Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions

Serum Proteomic Signatures in Cervical Cancer: Current Status and Future Directions

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Serum proteomics identify CSF1R as a novel biomarker for postoperative recurrence in chronic rhinosinusitis with nasal polyps

Contact Info

Product

Resources

About