Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders

Abstract

Objective: PS128 is a novel psycho biotic strain, it has been reported to play an important role in neuropsychiatric disorders. This study investigated the clinical effect of PS128 supplementation on patients with anxiety. Methods: A total of 200 patients with anxiety were recruited, and divided into two groups (n = 100/group). The control group received oral treatment with citalopram, and the PS128 group received PS128 capsules based on citalopram treatment. Hamilton Anxiety Scale (HAMA) and Self-Rating Anxiety Scale (SAS) were used to evaluate the anxiety levels. After 2 months of continuous administration, clinical efficacy was evaluated according to HAMA score. Results: There was no significant difference in HAMA and SAS scores between the two groups before treatment. With the treatment prolonged, the HAMA and SAS score decreased gradually in both control and PS128 groups, and the decrease rate of PS128 group was significantly greater than that of the control group. The clinical effective rates of PS128 group were higher than those in the control group, high levels of clinical cure rate were also detected in the PS128 group. Compared with the control group (22%), the incidence of adverse reactions was significantly reduced for patients in the PS128 group (4%). Conclusion: The treatment effect of citalopram combined with PS128 against anxiety is satisfactory clinically. It can greatly improve the anxiety symptoms of patients, increase the cure rate, reduce adverse reactions.

Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention

“… 72 , 73 We have demonstrated that PS128 treatment improves attention, communication skills, anxiety, and personal autonomy among individuals with ASD; these benefits appear to be consistent regardless of the initial genetic or environmental factors that contributed to the development of ASD and regardless of the extent of gut microbial community alterations. 21 , 74 , 75 To gain insight into the mechanistic effect of PS128 on ASD-associated behaviors, we treated VPA mice with PS128. Notably, PS128 not only ameliorated the core behavioral abnormalities associated with ASD in terms of social interactions ( Figure 1b–g ), but also demonstrated efficacy in addressing the key comorbidities of ASD in anxiety and cognitive deficits ( Figure 1i–l ).…”

The Improvement and Related Mechanism of Microecologics on the Sports Performance and Post-Exercise Recovery of Athletes: A Narrative Review

“…The supplementation of Lactobacillus plantarum PS128 for 8 weeks in another study on triathletes demonstrated a significant reduction in creatine kinase (CK) content. Additionally, the release of intense exercise-induced inflammatory factors and oxidative stress markers was also observed to be diminished [ 8 ]. The gut microbiota has been demonstrated to impact endurance performance in mice through the production of SCFAs [ 20 ].…”