Clinical Applications for the Use of Enzymatic Debriding Ointment and Broad-Spectrum Bacteriostatic Foam Dressing

Abstract

The optimal management of a chronic, nonhealing wound is challenging to experienced and novice clinicians alike. Treatment must be individualized, but principles of wound bed preparation, including debridement of necrotic tissue, maintenance of moisture in the wound, and prevention of bacterial overgrowth, guide the management of nonhealing wounds caused by a variety of different etiologies. This article summarizes our experiences with 2 products, collagenase ointment and crystal violet/methylene blue-impregnated foam, in the treatment of 3 nonhealing wounds.

Evaluation of a novel collagen-gelatin scaffold for achieving the sustained release of basic fibroblast growth factor in a diabetic mouse model

“…In patients suffering from these conditions, diabetic foot ulcers are a leading cause of hospitalization and amputation. Many advanced technologies, such as wound dressings, topical ointments, enzymatic debridement compounds and hyperbaric oxygen therapy, have been developed to improve the treatment of chronic skin ulcers (Heyneman et al ., ; Dunn and Dolianitis, ; McCallon and Hurlow, ; Collier, ; Baroni et al ., ; Oriani et al ., ; Kessler et al ., ; Ong, ). Recently, due to advances in tissue‐engineering and cell‐culture techniques, cultured skin substitutes have been used in the treatment of diabetic ulcers, pressure ulcers and venous leg ulcers (Karr, ; Ohara et al ., ; Cervelli et al ., ).…”