Clinical applications of 3D volume MR imaging of the fetal brain<i>in utero</i>

Jarvis, Deborah; Griffiths, Paul D.

doi:10.1002/pd.5042

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…Fetal MRI has been useful in evaluating abnormalities of fetal structures which are difficult to thoroughly evaluate by prenatal US alone, with obvious advantages over US in displaying neurological maturation and abnormalities (Grossman et al, 2006 ; Ruiz et al, 2017 ). The use of three-dimensional (3-D) volumetric in utero MRI is a relatively newer modality and allows more accurate measurement of intracranial structure volumes, which can more accurately reflect the growth of the fetal brain than 2-D parameters (Blondiaux and Garel, 2013 ; Jarvis and Griffiths, 2017 ; Kyriakopoulou et al, 2017 ; Takakuwa et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Quantification of Intracranial Structures Volume in Fetuses Using 3-D Volumetric MRI: Normal Values at 19 to 37 Weeks' Gestation

et al. 2022

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ObjectiveThe purpose of this study is to establish a reference of intracranial structure volumes in normal fetuses ranging from 19 to 37 weeks' gestation (mean 27 weeks).Materials and MethodsA retrospective analysis of 188 MRI examinations (1.5 T) of fetuses with a normal brain appearance (19–37 gestational weeks) from January 2018 to December 2021 was included in this study. Three dimensional (3-D) volumetric parameters from slice-to-volume reconstructed (SVR) images, such as total brain volume (TBV), cortical gray matter volume (GMV), subcortical brain tissue volume (SBV), intracranial cavity volume (ICV), lateral ventricles volume (VV), cerebellum volume (CBV), brainstem volume (BM), and extra-cerebrospinal fluid volume (e-CSFV), were quantified by manual segmentation from two experts. The mean, SD, minimum, maximum, median, and 25th and 75th quartiles for intracranial structures volume were calculated per gestational week. A linear regression analysis was used to determine the gestational weekly age-related change adjusted for sex. A t-test was used to compare the mean TBV and ICV values to previously reported values at each gestational week. The formulas to calculate intracranial structures volume derived from our data were created using a regression model. In addition, we compared the predicted mean TBV values derived by our formula with the expected mean TBV predicted by the previously reported Jarvis' formula at each time point. For intracranial volumes, the intraclass correlation coefficient (ICC) was calculated to convey association within and between observers.ResultsThe intracranial volume data are shown in graphs and tabular summaries. The male fetuses had significantly larger VV compared with female fetuses (p = 0.01). Measured mean ICV values at 19 weeks are significantly different from those published in the literature (p < 0.05). Means were compared with the expected TBV generated by the previously reported formula, showing statistically differences at 22, 26, 29, and 30 weeks' gestational age (GA) (all p < 0.05). A comparison between our data-derived formula and the previously reported formula for TBV showed very similar values at every GA. The predicted TBV means derived from the previously reported formula were all within the 95% confidence interval (CI) of the predicted means of this study. Intra- and inter-observer agreement was high, with an intraclass correlation coefficient larger than 0.98.ConclusionWe have shown that the intracranial structural volume of the fetal brain can be reliably quantified using 3-D volumetric MRI with a high degree of reproducibility and reinforces the existing data with more robust data in the earlier second and third stages of pregnancy.

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Section: Introductionmentioning

confidence: 99%

Quantification of Intracranial Structures Volume in Fetuses Using 3-D Volumetric MRI: Normal Values at 19 to 37 Weeks' Gestation

et al. 2022

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“…To add accuracy to the morphology side of the axiom, new quantitative methods such as volume-rendering quantifications, diffusion tensor imaging, and functional MRI should be added to such protocols. [7][8][9] The fundamental message from Hart and colleagues' work is a warning against overconfidence in the sole use of iuMRI-based prognostication. Considering that this work was limited to 3 years of follow-up, our knowledge of outcomes in school-age children is currently unexplored territory.…”

Section: Determinants Of Youth Crime In Low-income and Middleincome Cmentioning

confidence: 99%

Morphology and function: from fetal brain image to childhood outcomes

Righini

2020

The Lancet Child & Adolescent Health

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“…Our group has been able to build up a database of normative volume data from 200 fetuses using this method (Fig. ) and this information has been vital to demonstrate how brain size is altered when abnormalities are present …”

Section: Advanced Mri Techniquesmentioning

confidence: 99%

“…information has been vital to demonstrate how brain size is altered when abnormalities are present. 69…”

Section: Measurement Of Fetal Brain Volumementioning

confidence: 99%

Current state of MRI of the fetal brain in utero

Jarvis

Griffiths

2018

Magnetic Resonance Imaging

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In this article we provide an overview of fetal brain development, describe the range of more common fetal neuropathology, and discuss the relevance of in utero MR (iuMR). Although ultrasonography remains the mainstay of fetal brain imaging, iuMR imaging is both feasible and safe, but presents several challenges. We discuss those challenges, the techniques employed to overcome them, and new approaches that may extend the clinical applicability of fetal iuMR. Level of Evidence: Technical Efficacy Stage. J. Magn. Reson. Imaging 2019;49:632–646.

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Clinical applications of 3D volume MR imaging of the fetal brainin utero

Abstract: 3D volume in utero MR imaging appears to be a promising method in the prenatal assessment of the fetal brain. We propose possible areas of future research that are required to assess the techniques potential to have clinical impact. © 2017 John Wiley & Sons, Ltd.

Cited by 8 publications

References 14 publications

Quantification of Intracranial Structures Volume in Fetuses Using 3-D Volumetric MRI: Normal Values at 19 to 37 Weeks' Gestation

Quantification of Intracranial Structures Volume in Fetuses Using 3-D Volumetric MRI: Normal Values at 19 to 37 Weeks' Gestation

Morphology and function: from fetal brain image to childhood outcomes

Current state of MRI of the fetal brain in utero

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