Clinical applications of angiotensin-converting enzyme inhibitors

Ferguson, Roger K.; Vlasses, Peter H.; Rotmensch, Heschi H.

doi:10.1016/0002-9343(84)90367-x

Cited by 37 publications

(12 citation statements)

References 90 publications

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“…ACE inhibitors have been used in the treatment of hypertension and congestive heart failure since 1977 when captopril, the first orally active ACE inhibitor, was introduced [16]. Apart from arterial hypertension where ACE inhibitors are recommended as first-line therapy by current guidelines [17], they are also recommended in several conditions.…”

Section: Discussionmentioning

confidence: 99%

Effects of enalapril and imidapril in the capsaicin cough challenge test and spirometry parameters in healthy volunteers

Silveira¹,

Vaz‐da‐Silva²,

Maia³

et al. 2004

Therapy

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Section: Discussionmentioning

confidence: 99%

Effects of enalapril and imidapril in the capsaicin cough challenge test and spirometry parameters in healthy volunteers

Silveira¹,

Vaz‐da‐Silva²,

Maia³

et al. 2004

Therapy

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“…Today it is well known that ACE-inhibitors, used as therapeutic tools in the treatment of hypertension and congestive heart failure, are associated with adverse reactions in which the pathophysiology seems to be of inflammatory origin (Wilkin et al 1980;Sesoko & Kaneko 1985;Semple & Herd 1986;Suares et al 1986;Lindgren 1988). Several newly synthesized ACE-inhibitors are undergoing clinical evaluation in order to find ACE-inhibitors with fewer side effects and better safety profiles (Ferguson et al 1984;Fyhrqvist 1986). The pro-inflammatory effect of the ACE-inhibitor is related to the dosage (Wilkin et al 1980;Lindgren & Anderson 1989), as well as to its duration (Reid 1984;Skidgel et al 1984).…”

Section: Discussionmentioning

confidence: 99%

Effects of Cilazaprilat and Enalaprilat on Experimental Dermatitis in Guinea Pigs

Rosenqvist¹,

Persson²,

Lindgren³

et al. 1991

Pharmacology & Toxicology

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Two non-sulfur containing ACE-inhibitors were tested concerning their local effect on experimental dermatitis in ovalbumin-sensitized guinea pigs. Enalaprilat but not cilazaprilat potentiated the ovalbumin-evoked inflammatory response. Furthermore, enalaprilat clearly enhanced the erythema evoked by substance P, whereas cilazaprilat did not. Concerning, the bradykinin-evoked erythema, enalaprilat significantly potentiated the response, whereas cilazaprilat only caused a slight increase. Our results suggest that different affinities for peptidases involved in degradation of inflammatory peptides can explain differences between the pro-inflammatory properties of enalaprilat and cilazaprilat.

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“…One incentive in inhibitor research is the control of limited proteolysis, as this constitutes a valuable pharmacological tool. Proteinase inhibitors have been proved effective in human therapy [10][11][12][27][28][29]. A pathological increase in fibrinolysis, e.g.…”

Section: Introductionmentioning

confidence: 99%

Kinetic behaviour of zymogen activation processes in the presence of an inhibitor

Varón

Manjabacas

García-Moreno

et al. 1993

Biochemical Journal

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A global kinetic analysis of a general zymogen activation model, where not only the activating but also the activated enzyme suffer an irreversible inhibition is presented. A reaction in which the enzyme acts upon a substrate is coupled to monitor the process. In addition, we determined the corresponding kinetic equations for a number of particular cases of the general model studied. Finally, a kinetic data analysis and a procedure to discriminate among the different mechanisms considered, which are based on the kinetic equations obtained, are suggested.

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Clinical applications of angiotensin-converting enzyme inhibitors

Cited by 37 publications

References 90 publications

Effects of enalapril and imidapril in the capsaicin cough challenge test and spirometry parameters in healthy volunteers

Effects of enalapril and imidapril in the capsaicin cough challenge test and spirometry parameters in healthy volunteers

Effects of Cilazaprilat and Enalaprilat on Experimental Dermatitis in Guinea Pigs

Kinetic behaviour of zymogen activation processes in the presence of an inhibitor

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