Clinical Applications of Biomarkers in Preeclampsia

Abstract

Preeclampsia remains a significant cause of maternal morbidity and mortality worldwide. Prediction, diagnosis and management continue to be challenging but advances in the understanding of the pathophysiological processes underlying the disease has enabled identification of multiple biomarkers, some of which aid prediction of those at risk. Even in isolation, some of these biomarkers have demonstrated sufficient test performance for incorporation into clinical practice. A combination of the most promising biomarkers and clinical factors may improve risk prediction, and aid diagnosis and subsequent management through development of integrated clinical risk models. This article aims to review the literature relating to biomarkers in preeclampsia and summarize the possible clinical applications of these findings.

Animal models of preeclampsia: translational failings and why

“…Early onset is defined as symptom development before 34 wk gestation, whereas late onset is defined as development after 34 wk gestation (106). Several biochemical markers have now been identified in the maternal circulation to help predict and diagnose preeclampsia (39). These include antiangiogenic and angiogenic factors, markers for renal dysfunction, endothelial dysfunction, oxidative stress, and inflammatory markers, highlighting the very diverse nature of the disease (85).…”

Colesterol sérico en el segundo trimestre del embarazo como predictor de preeclampsia.

“…Estudios previos que evaluaron la asociación entre las concentraciones de lípidos durante el embarazo y el riesgo de preeclampsia han sugerido que las mediciones de lípidos es una forma de 'pesquisa' durante el embarazo temprano en mujeres con riesgo para desarrollar la patología (28) . Los resultados de la investigación indican que las concentraciones de colesterol fueron significativamente diferentes entre las pacientes que desarrollan preeclampsia y aquellas que no desarrollan el síndrome en el segundo trimestre, por lo cual puede ser una herramienta ideal para la predicción efectiva de la aparición del síndrome.…”

The Management of Preeclampsia: A Comprehensive Review of Current Practices and Future Directions

“…The Bishop score upon admission serves as the best indicator of a successful delivery. However, the probability of a successful induction increases with advancing gestational age [ 17 ]. Strong evidence suggests that opting for a scheduled delivery reduces the risk of maternal complications and severe hypertension when compared to waiting and managing the situation expectantly.…”