Clinical Applications of Injectable Biomaterials

Ercan, Hatice; Durkut, Serap; Koc-Demir, Aysel; Elçin, Ayşe Eser; Elçin, Yaşar Murat

doi:10.1007/978-981-13-0947-2_10

Cited by 19 publications

(6 citation statements)

References 140 publications

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“…), которые в определенной форме (наиболее оптимальная -микросферы) могут быть введены в виде инъекции [36,37]. Локальное введение таких материалов безопаснее и эффективнее, поскольку посредством системного введения через внутривенную инъекцию лишь 10 % от первоначальной дозы достигает органа-мишени [38,39]. Однако эти данные на сегодняшний момент подтверждены лишь для повреждений тканей сердечно-сосудистой системы, костей, хрящей и кожи, в то время как доставка скаффолдов в другие ткани и органы все еще требует изучения.…”

Section: обзоры литературы / Reviewsunclassified

Viral Delivery Using Scaffolds

Лаевская

Kosenchuk

Якушов

et al. 2021

Rossijskij bioterapevtičeskij žurnal

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In experimental oncology there are multiple approaches have been developed to target tumor cells. Many of them are based on scaffolds, a 3D models that mimics the structure of tissue in normal and pathophysiological state. It is known that to deliver a viral load to target cells, cells-carriers undergo limited differentiation, and premature aging. Since viral agents require cells to be in specific proliferative state, the delivery of the virus to the target cell is the main goal of the functional framework such as scaffold. Over decade, multiple studies demonstrate the production of scaffolds using matrigel, polyalacinic acid, poly-lactide-co-glycolide, vinyl stilbens, or bioactive polymers. Our review will describe the potential benefits of delivering the viral vector using 3D scaffolds for virus-mediated expression of biologically active substances that prevent angiogenesis, neoplasm proliferation, or, conversely, stimulate wound healing. 3D materials such as hydrogels and scaffolds are among the key innovations in the field of material chemistry. Moreover, viral vectors provide specific delivery of genes to target cells. However, the immunogenicity of a viral capsid consisting of viral proteins hinders the clinical use of such vectors widely. These limitations can be surmounted by using scaffolds. Therefore, our review might interest researchers working in the fields of chemistry, materials science and natural sciences, as well as in the field of bioengineering and medical technologies.

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Section: обзоры литературы / Reviewsunclassified

Viral Delivery Using Scaffolds

Лаевская

Kosenchuk

Якушов

et al. 2021

Rossijskij bioterapevtičeskij žurnal

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“…Injectable biomaterial in tissue regeneration [46] In the recent research carried out by Bencherif et al, an alginate-based cryogel biomaterial was studied as an injectable cancer vaccine using CpG as a danger signal, GM-CSF for cell recruitment, and irradiated melanoma cells as antigen source. RGD peptides were incorporated into the cryogel for better adhesion of irradiated melanoma cells.…”

Section: Figurementioning

confidence: 99%

Overview of implantable and injectable biomaterials in immunotherapy

Prakash¹,

Agrawal²,

Reddy³

2021

GSC Biol. and Pharm. Sci.

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Immunotherapy has shown promising applications in cancer treatment as it boosts the systemic immune response. Existing immunotherapy strategies have certain drawbacks which can be addressed by engineered biomaterials. In this review, we focused on advanced immunotherapy methods involving implantable and injectable biomaterials for the treatment of cancer. Engineered biomaterials as carriers for immunomodulatory agents aid in the local drug delivery, thus reducing the frequency of off-target side effects. Also, biomaterial-based cancer vaccines have the potential to target specific tissues by finely altering the physical properties of the drug to achieve desired drug release kinetics.

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“…In recent years, the use of EcM-P for surgical applications has become increasingly prevalent, especially for the field of nerve regeneration and bone repair (60). It is well known that EcM-P contain a complex meshwork of proteins and polysaccharides, which provides biochemical support to the surrounding cells for promoting their survival, proliferation and differentiation (61).…”

Section: Application Of Ecm-p In Regenerative Medicinementioning

confidence: 99%

Extracellular matrix grafts: From preparation to application (Review)

Jiang

Han

et al. 2020

Int J Mol Med

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Recently, the increasing emergency of traffic accidents and the unsatisfactory outcome of surgical intervention are driving research to seek a novel technology to repair traumatic soft tissue injury. From this perspective, decellularized matrix grafts (ECM-G) including natural ECM materials, and their prepared hydrogels and bioscaffolds, have emerged as possible alternatives for tissue engineering and regenerative medicine. Over the past decades, several physical and chemical decellularization methods have been used extensively to deal with different tissues/organs in an attempt to carefully remove cellular antigens while maintaining the non-immunogenic ECM components. It is anticipated that when the decellularized biomaterials are seeded with cells in vitro or incorporated into irregularly shaped defects in vivo , they can provide the appropriate biomechanical and biochemical conditions for directing cell behavior and tissue remodeling. The aim of this review is to first summarize the characteristics of ECM-G and describe their major decellularization methods from different sources, followed by analysis of how the bioactive factors and undesired residual cellular compositions influence the biologic function and host tissue response following implantation. Lastly, we also provide an overview of the in vivo application of ECM-G in facilitating tissue repair and remodeling.

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Clinical Applications of Injectable Biomaterials

Cited by 19 publications

References 140 publications

Viral Delivery Using Scaffolds

Viral Delivery Using Scaffolds

Overview of implantable and injectable biomaterials in immunotherapy

Extracellular matrix grafts: From preparation to application (Review)

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