Clinical Applications of Leukocyte Morphological Parameters

Xu, Dongsheng

doi:10.23937/2469-5807/1510002

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…Previous studies have showed that changes in leukocyte morphology in various clinical conditions can be quantitatively measured by Beckman-Coulter hematology analyzers with VCS technology [3,4]. In this study, we demonstrated that LV and MV in RA-A patients are significantly increased compared to controls and positively correlated with CRP and ESR.…”

supporting

confidence: 60%

“…This so-called VCS technology is analogous to the microscopic evaluation of a peripheral blood smear, but uses advanced technology to refine the output for increased accuracy. Previous studies have demonstrated that morphologic changes of activated lymphocytes or monocytes in various infectious disorders can be quantitatively measured using VCS technology [3,4]. We hypothesized that the morphologic changes in activated lymphocytes and monocytes in patients with active RA may be detected by VCS technology.…”

mentioning

confidence: 98%

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Mean lymphocyte volume and mean monocyte volume are associated with disease activity in rheumatoid arthritis

Yu¹,

Zhu²,

Xu³

et al. 2015

Int J Lab Hematology

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supporting

confidence: 60%

mentioning

confidence: 98%

Mean lymphocyte volume and mean monocyte volume are associated with disease activity in rheumatoid arthritis

Yu¹,

Zhu²,

Xu³

et al. 2015

Int J Lab Hematology

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“…However, MDW outperformed MNV, NDW, and all other volumetric metrics (MMV, mean corpuscular volume, and mean platelet volume; data not shown) for the detection of sepsis, particularly in the diagnostically challenging subgroup of patients in the ED presenting with SIRS (Fig 3B). We posit that monocyte parameters may perform better because circulating monocytes are first responders to infections, 33,34 and the response is proportional to the intensity of the exposure to either bacterial, fungal, or viral pathogens, 35 resulting in an acute increase in monocyte size. 36,37 In contrast, the neutrophil response to certain infections (eg, viral 38,39 ) is relatively delayed.…”

Section: Discussionmentioning

confidence: 99%

Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker

Crouser

Parrillo

Seymour

et al. 2017

Chest

148

186

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“…This phenomenon suggested that when sepsis and local infections had occurred, neutrophils, monocytes, and lymphocytes became larger in size, as newborn cells tended to be immature and larger. In addition, MDW increased in the septic and locally infected groups because circulating monocytes were the first responders to infections [21,22] and the response was proportional to the intensity of exposure to bacteria and fungi [23]. This led to a sharp increase in monocyte size [24], which has not been shown in the monocyte ratio (MO%) ( Table 3).…”

Section: Disease Markersmentioning

confidence: 95%

The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

et al. 2019

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Background. Patients with liver cirrhosis have a high risk of sepsis and a poor prognosis. Recently, a new standard for sepsis (Sepsis-3) has been proposed in the general population. The Coulter Lh 750 hematology analyzer can evaluate mean volume, conductivity, scatter, and distribution width of leukocyte. We tried to use Sepsis-3 criteria to study the diagnostic value of volume, conductivity, and scattering (VCS) parameters in sepsis and infection in patients with liver cirrhosis compared with traditional infection markers (PCT, IL-6, sCDl63). Methods. A blinded, cohort study was conducted in three different ED populations within three affiliated hospitals. A total of 249 patients with liver cirrhosis were enrolled in the study. According to the "Sepsis-3" consensus criteria, clinical history, and laboratory examination, the subjects were divided into sepsis (n = 54), patients with infections (n = 95), and patients without systemic infections (n = 100). The blood samples of the patients were collected at the time of ED admission and were evaluated for the detection of sepsis. Results. The differences of MNV, MNS, MMV, MMS, MLV, NDW, and MDW in the three groups were statistically significant. In the diagnosis of sepsis in patients with liver cirrhosis, the sensitivity of combined detection of MMV and MDW was 88.89%; the specificity was 74%. This sensitivity was significantly better than the 83.3% achieved using 0.97 mg/L as the cutoff for sCD163. In the diagnosis of infection in cirrhosis, the sensitivity of combination of MNV and MMS was increased to 86.32%; the specificity was 92%. The sensitivity was the same as that achieved by using 0.31 ng/mL as the cutoff value of PCT, but the specificity increased. Conclusion. The leukocyte VCS parameter could be potential parameters for indicating sepsis and infection in patients with liver cirrhosis. The combined detection of MMV and MDW seemed to be helpful for the diagnosis of sepsis in these patients, and the combination of MNV and MMS could better indicate infection for them.

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Clinical Applications of Leukocyte Morphological Parameters

Cited by 12 publications

References 34 publications

Mean lymphocyte volume and mean monocyte volume are associated with disease activity in rheumatoid arthritis

Mean lymphocyte volume and mean monocyte volume are associated with disease activity in rheumatoid arthritis

Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker

The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

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