Clinical Applications of Platelet Antibody and Antigen Testing

Lochowicz, Andrew J.; Curtis, Brian R.

doi:10.1309/lmm242gkghckjrwi

Cited by 12 publications

(15 citation statements)

References 29 publications

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“…ITP, formerly called idiopathic thrombocytopenic purpura, is caused by acquired autoantibodies with broad reactivity against common epitopes on platelet glycoprotein complexes . ITP is a diagnosis of exclusion and routine testing for platelet antibodies is not recommended , but may sometimes be useful to confirm an immune cause . Some authors have found that identification of platelet‐associated antibodies has prognostic significance in ITP .…”

Section: Disorders Caused By Platelet Autoantibodiesmentioning

confidence: 99%

“…The MAIPA method differs from MACE in that the platelets are also incubated with a glycoprotein‐specific antibody, in addition to patient serum, prior to detergent lysis. This complex is then captured onto the plate for antibody detection .…”

Section: Laboratory Testsmentioning

confidence: 99%

“…Immune‐mediated thrombocytopenias result from alloantibodies or autoantibodies directed against platelet surface antigens. Platelet‐specific cell‐surface antigens are called human platelet antigens (HPA), and greater than 25 HPA have been described . Platelets also express non‐platelet‐specific antigens such as HLA class I and blood group antigens that can be involved in immune thrombocytopenias (ITPs) .…”

Section: Introductionmentioning

confidence: 99%

“…Platelet‐specific cell‐surface antigens are called human platelet antigens (HPA), and greater than 25 HPA have been described . Platelets also express non‐platelet‐specific antigens such as HLA class I and blood group antigens that can be involved in immune thrombocytopenias (ITPs) . This Test of the Month feature summarizes the major immune‐mediated thrombocytopenias with particular focus on laboratory testing applications.…”

Section: Introductionmentioning

confidence: 99%

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Laboratory testing for platelet antibodies

Heikal

Smock

2013

American J Hematol

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Laboratory testing for immune-mediated thrombocytopenias involves identification and classification of antibodies present in patient sera or attached to patient platelets. This article summarizes the available types of platelet antibody testing and applications in disorders such as neonatal alloimmune thrombocytopenia, post-transfusion purpura, multiple platelet transfusion refractoriness, immune thrombocytopenia, and drug-induced thrombocytopenia. Am. J.

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Section: Disorders Caused By Platelet Autoantibodiesmentioning

confidence: 99%

Section: Laboratory Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laboratory testing for platelet antibodies

Heikal

Smock

2013

American J Hematol

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“…1 Individu sehat memiliki kadar trombosit dalam darah 150x10 9 hingga 400x10 9 trombosit per liter. Trombositopenia dapat menyebabkan gejala perdarahan yang bervariasi dari petekiae hingga perdarahan intrakranial, perdarahan paru, dan kematian.…”

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Efektivitas Transfusi Trombosit Hasil Uji Silang Serasi (Crossmatch) pada Kondisi Trombositopenia Refrakter

Andriastuti

Chozie

Rahmani

2018

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Latar belakang. Penyebab imun tersering trombositopenia refrakter adalah adanya antibodi terhadap human leukocyte antigens (HLA) dan atau human platelet antigens (HPA). Salah satu strategi untuk mengidentifikasi unit trombosit yang kompatibel untuk resipien adalah dengan uji silang serasi (crossmatching).Tujuan. Mengetahui efektivitas uji silang serasi sebagai tata laksana trombositopenia refrakter.Metode. Penelusuran literatur secara daring, digunakan instrumen pencari Pubmed, Cochrane, Clinical key, dan Google Scholar. Kata kunci yang digunakan adalah ”crossmatching”,”platelet transfusion”,“thrombocytopenia”, “refractory”, dan “efficacy”.Hasil. Terdapat 3 artikel yang relevan dengan masalah. Penelitian kohort terhadap 100 transfusi trombosit dengan uji silang serasi menunjukkan hasil rerata 24 jam jumlah trombosit pascatransfusi secara signifikan lebih tinggi pada kelompok kompatibel (9,250±026,6) daripada kelompok inkompatibel (6,757.94±2,656.5), p<0.0001. Penelitian kohort yang kedua juga menunjukkan perbedaan kenaikan jumlah trombosit pascatransfusi antara kelompok kompatibel dan inkompatibel bermakna secara signifikan (p=0,041). Pada penelitian kohort ketiga, transfusi trombosit inkompatibel terbukti meningkatkan risiko terjadinya respons kenaikan trombosit yang buruk pada 1 jam (OR: 5,38; 95% CI: 2,060-14,073; p<0,001), tetapi tidak pada 24 jam (OR: 1,400; CI: 0,572-3,434; p=0,46). Terdapat perbedaan bermakna antara jumlah absolut trombosit pada 1 jam dan 24 jam pascatransfusi trombosit (p<0,001). Kesimpulan. Transfusi trombosit hasil uji silang serasi yang kompatibel efektif diberikan pada pasien dengan kondisi trombositopenia refrakter.

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Alloantibodies and Platelets

Wool¹,

Brown²

2020

Immunologic Concepts in Transfusion Medicine

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Clinical Applications of Platelet Antibody and Antigen Testing

Cited by 12 publications

References 29 publications

Laboratory testing for platelet antibodies

Laboratory testing for platelet antibodies

Efektivitas Transfusi Trombosit Hasil Uji Silang Serasi (Crossmatch) pada Kondisi Trombositopenia Refrakter

Alloantibodies and Platelets

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