Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Abstract

Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated with sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization. It has also been used to treat skin diseases such as photodermatoses, photoaggravated inflammatory conditions and pigmentary disorders. This review examines the most recent developments in the clinical application of Fernblock® and assesses how newly investigated action mechanisms may influence its clinical use.

New trends on personalized sunscreens

“…Fernblock ∅ as a part of topical sunscreen can prevent the increased oxidative stress and DNA damage produced by the synergistic effect between BaP and UVA radiation, and promote the overexpression of the opsin-3 photoreceptor, a protein that is directly related to melanogenic cellular pathways. 88…”

“…Fernblock®, a standardized aqueous extract of the fern PLE, has been widely administered both topically and orally with a strong safety profile. Fernblock ∅ as a part of topical sunscreen can prevent the increased oxidative stress and DNA damage produced by the synergistic effect between BaP and UVA radiation, and promote the overexpression of the opsin‐3 photoreceptor, a protein that is directly related to melanogenic cellular pathways 88 …”

Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

“…According to the relevant research, subjects received 480 mg of PL for 60 days, reflecting a higher overall exposure to the substance. There were no reports of adverse events, as in prior clinical investigations [65,[68][69][70][71].…”