2011
DOI: 10.1111/j.1872-034x.2011.00819.x
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Clinical applications of positron emission tomography in hepatic tumors

Abstract: Fluorodeoxyglucose (FDG), which allows the evaluation of glucose metabolism, is widely used for tumor diagnosis using positron emission tomography (PET). FDG-PET, which is used for the diagnosis of intrahepatic tumor lesions, shows high FDG accumulation in cholangiocellular carcinoma (CCC) and metastatic liver cancer. FDG-PET shows high FDG accumulation in moderately or poorly differentiated hepatocellular carcinoma (HCC) and is useful for the diagnosis of extrahepatic HCC metastases and recurrences. However, … Show more

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Cited by 30 publications
(26 citation statements)
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“…Therefore, rigid experimental controls should be set in place to eliminate interfering variables that indirectly alter pHe when studying the effect of hypoxia on tumor cells or the Warburg effect. Changes in pHe are introduced by factors such as the gas composition itself (O 2 , N 2 , CO 2 ), metabolic response to the change in gas (lactate or CO 2 released in a closed system), selected volume/depth of media, cell plating density, inherent metabolic rates or choice of buffering agents in the media, which could mask true effects . Studies should either utilize a means to control the pH to determine the true effect of gases, or should employ a means to hold the gases constant to study the effect of pH change.…”
mentioning
confidence: 99%
“…Therefore, rigid experimental controls should be set in place to eliminate interfering variables that indirectly alter pHe when studying the effect of hypoxia on tumor cells or the Warburg effect. Changes in pHe are introduced by factors such as the gas composition itself (O 2 , N 2 , CO 2 ), metabolic response to the change in gas (lactate or CO 2 released in a closed system), selected volume/depth of media, cell plating density, inherent metabolic rates or choice of buffering agents in the media, which could mask true effects . Studies should either utilize a means to control the pH to determine the true effect of gases, or should employ a means to hold the gases constant to study the effect of pH change.…”
mentioning
confidence: 99%
“…Recent studies have shown that PET/CT is useful in assessing tumor characterization. Low 18 F-FDG uptake is seen in well-differentiated HCC, whereas high 18 F-FDG uptake is observed in moderately to poorly differentiated HCC (18,19). After the uptake…”
mentioning
confidence: 99%
“…Because only approximately 50%-70% of HCC tumors exhibit glucose metabolism higher than that of the liver parenchyma (14,15), conventional late static whole-body (WB) 18 F-FDG PET combined with CT plays a subordinate role in HCC primary diagnosis. However, this procedure is often used to help confirm liver transplant eligibility by excluding extrahepatic tumor (16,17).…”
mentioning
confidence: 99%