Clinical Applications of Skin Bank Bioproducts

Tognetti, Linda; DePiano, Ernesto; Perotti, Roberto; Cencetti, Chiara; Panzano, Claudia; Zerini, Federico; Donato, Gianmarco de; Palasciano, Giancarlo; Gennaro, Paolo; Lorenzini, G.; Griamldi, Luca; Pianigiani, Elisa; Rubegni, Pietro

doi:10.1007/978-3-030-45351-0_42

Cited by 5 publications

(21 citation statements)

References 17 publications

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“…On the extremities, rotation/transposition/flaps are not possible, hence the need for homologous grafts is relevant. 5,9,41,42 Moreover, even minor mechanical injuries on lower limbs in elderly patients with compromised arterial/venous circulation/diabetes/lymphoedema, can determine wounds not easily managed by standards of care. Timely recognition and treatment with hADMs can thus prevent the degeneration into chronic ulcers.…”

Section: Post-traumatic Woundsmentioning

confidence: 99%

“…4,5 This also because the transient immunodepression allowed the partial integration of meshed hypo-cellulated dermal allografts into the wound bed. 6,9,40,45,46 More recently, the introduction of hADMs has provided a non-immunogenic structure to be used in those patients. 45 The first experience dates back to 1996, when Wainwright reported similar take rates for the hADMs vs control autografts.…”

Section: Burnsmentioning

confidence: 99%

“…Surgeons and physicians progressively developed multiple techniques for the hADMs use, tailored to specific requirements. [9][10][11][12][13][14][15][16][17][18][19] As a consequence, the demand for hADMs, especially lyophilized (ie, freezedried) hADMs, is currently growing worldwide and is addressed to Tissue Establishments or Commercial Companies. 7,8,11 In Europe, hADMs are considered "human products" as per the European regulations on tissue transplants, thus can beonly donated, after processing and release by Tissue Establishments (ie, skin banks).…”

mentioning

confidence: 99%

“…11 On the other hand, outside the European Community, hADMs can be commercialized as medical devices, can be produced and sold by Commercial Companies. 4,5,9,11 The present review aims to illustrate the main body of experience reported on the use of hADMs in the different surgical and clinical settings, and discuss the peculiar advantages reached with their use compared with the biologic, synthetic and semi-synthetic ADMs.…”

mentioning

confidence: 99%

“…Summarizing the body of evidence to date collected, hADMs appear to be able to prevent bowel adhesions/ obstruction and fistulas as well as the relapses of sacroperineal hernias, if the common requirements for a successful outcome in all these conditions is the placement of the hADM graft correctly positioned between two well-vascularized tissues planes. 16175,266 | ORAL CAVITYMultiple application of hADMs of different shapes/thickness were found in the oral cavity in the last 10 years, ranging from the reconstruction of post-surgical defects (tongue, buccal mucosa, hard palate or lips) to the periodontal pathology5,9,26,27 Generally, they are used as whole layers rather than meshed, sutured directly onto the wound bed with re-absorbable stiches (Figure2). Using hADMs for intraoral reconstruction proved to reduce the re-epithelialization time by minimizing the patient pain and discomfort.…”

mentioning

confidence: 99%

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The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

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Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to replace the loss of autologous dermis, by acting as a physiological scaffold that add structural support to soft tissues. To date, human ADMs (hADMs) have been employed in the reconstruction of skin defects affecting almost all body sites, ranging from visceral sites to the skin and subcutaneous tissues. This review aims to investigate the use of hADM at different body sites and their peculiar advantages. A literature search was using the search terms "acellular dermal matrices", "dermal regeneration", "advances wound healing", "human acellular dermal matrices surgery". A total of 50 out of 150 papers was included. Based on the current body if evidence, hADMs appear to bring several advantages, such as: protection of deep structures (eg, tendons, bones, cartilage and nerves); stimulation of a functional new dermis (rather than a scar); reduction of wound closure time; control of pain and exudate. Finally, hADMs may represent the best treatment option for hard-to-heal wound not only in terms of efficacy and patient satisfaction bout also in terms of sanitary costs, especially across Europe, where hADMs cannot be commercialized as medical devices.

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Section: Post-traumatic Woundsmentioning

confidence: 99%

Section: Burnsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

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Hard-to-treat wound due to trabectidine extravasation: first case successfully treated with human lyophilized acellular dermis

Tognetti

Cioppa

Cinotti

et al. 2023

Ital J Dermatol Venereol

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From Bank Preparation to Clinical Use of Homologous Skin Allografts in Wound Healing: A Sustainable Approach

Amoroso,

Agueci,

Pianigiani

et al. 2024

Life

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Given progressive population ageing and the increase in the number of patients with comorbidities, the management of chronic and/or hard-to-heal wounds (HHWs) nowadays represents a common problem in many clinical settings. In these cases, standard strategies may not be sufficient. Autologous grafting represent the gold standard for permanent wound closure, but is almost never realized when the skin loss is extensive/the patient is young. The grafting of homologous skin/dermal tissue procured from cadaver donors (i.e., allografting) represents the best alternative, especially when the dermal component is lost. This request supports the activities of skin bank establishments (including donor screening, skin procurement, processing, storage, and distribution) that are regulated by specific guidelines and need to continuously meet quality standard requirements. The aim of this work is to both give specific insights of all the procedures implied in allograft preparation as well as an overview of their practical application in the treatment of different HHWs. The particular characteristics of each skin/dermal allograft released by Siena Skin Bank (cryopreserved/glycerol-preserved skin/de-epidermized dermis, acellular lyophilized de-epidermized dermis/reticular dermis) are also discussed. The exemplificative series of HHWs managed in the Dermatology Department of Siena were classified according their etiology into post-traumatic, vascular (arterial/venous/mixed/lymphatic), inflammatory, surgical, and heat/chemical burns. Globally, the clinical advantages obtained include: acceleration of healing process, pain sparing, resistance to bacterial contamination, dermal regeneration (instead of scarring), and better aesthetic–functional outcome.

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Clinical Applications of Skin Bank Bioproducts

Cited by 5 publications

References 17 publications

The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Hard-to-treat wound due to trabectidine extravasation: first case successfully treated with human lyophilized acellular dermis

From Bank Preparation to Clinical Use of Homologous Skin Allografts in Wound Healing: A Sustainable Approach

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