Clinical Applications of Transdermal Iontophoresis

Kalaria, Dhaval R.; Dubey, Sachin

doi:10.1002/9781118140505.ch4

Cited by 5 publications

(7 citation statements)

References 74 publications

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“…pulsatile liberation of gonadotropin releasing hormone (GnRH), and thereby offers a potentially more convenient alternative to IV infusion ( Kalia et al, 2004 ). Furthermore, transdermal iontophoresis is also one of the approaches that has resulted in approved therapeutic products ( Kalaria et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue

Dubey

Perozzo

Scapozza

2020

International Journal of Pharmaceutics: X

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The first objective was to investigate the transdermal iontophoresis of interferon beta 1b (IFN); the second was to determine whether the addition of 10 Arg residues at the N-terminus, creating a highly charged poly-Arg analogue (Arg 10 -IFN), increased delivery. Cumulative permeation of IFN and Arg 10 -IFN after iontophoresis at 0.5 mA/cm 2 for 8 h was 6.97 ± 4.82 and 9.55 ± 1.63 ng/cm 2 , respectively – i.e. >1000-fold less than that of ribonuclease A, cytochrome c and human basic fibroblast growth factor. Co-iontophoresis of acetaminophen showed that, in contrast to lysozyme, neither IFN nor Arg 10 -IFN interacted with skin to decrease convective solvent flow. Furthermore, there was no statistically significant difference between (i) iontophoretic delivery of IFN across intact or laser porated skin and (ii) passive or iontophoretic delivery of IFN across laser porated skin. Chromatographic characterisation supported the hypothesis that IFN was bound strongly to albumin. The formation of a ~ 86 kDa complex with albumin was probably responsible for the poor cutaneous delivery of IFN/Arg 10 -IFN despite the use of iontophoresis and/or laser microporation. Biopharmaceuticals might interact with specific proteins during iontophoretic transport and so decrease their (per)cutaneous delivery without affecting electroosmotic solvent flow, which is usually considered as a reliable marker to report on permeant binding during electrotransport across the skin.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue

Dubey

Perozzo

Scapozza

2020

International Journal of Pharmaceutics: X

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“…Insulin, ketoprofen and vaccines [93,95,165] Increased driving force technologies Iontophoresis Transdermal delivery by a small direct current Charged molecules, peptides, proteins and indomethacin [97,98,166] Dermaportation or magnetophoresis Delivery using static or variable magnetic fields Benzoic acid, terbutaline sulfate, 5-ALA, Ala-Trp (dipeptide) and naltrexone [100][101][102][103][104] ALA: Aminolevulinic acid.…”

Section: Cavitation Technologiesmentioning

confidence: 99%

“…In addition to the direct repulsion mechanism, there are two other mechanisms that contribute to increased skin flux under iontophoresis: electro-osmotic effects on unionized but polar species and increased permeabilization of the skin as a result of the electric current. Along with sonophoresis, iontophoresis is one of the few transdermal delivery technologies with clearly identifiable clinical applications, and it is the only one to produce US FDA-approved products [98]. Early work by Murthy and Hiremath reported that static magnetic fields were able to increase penetration of topically applied benzoic acid and terbutaline sulfate in vitro and in vivo in guinea pigs and humans [99,100].…”

Section: Increased Driving Force Technologiesmentioning

confidence: 99%

Delivery of drugs applied topically to the skin

Leite-Silva¹,

Almeida²,

Fradin

et al. 2012

Expert Review of Dermatology

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“…This could be explained by changing the degree of ionization of diclofenac due to competitive interaction between carboxylic acid groups of both gellan and diclofenac for the sodium ions. The degree of ionization of drugs has an effect on drug partitioning into the skin (Kalaria et al, 2012). The free acid of diclofenac can permeate the skin faster than diclofenac salts (Minghetti et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Gellan gum fluid gels for topical administration of diclofenac

Mahdi

Conway

Mills

et al. 2016

International Journal of Pharmaceutics

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Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging due to the natural protective feature of the stratum corneum (SC). In this article, fluid gels prepared from gellan gum were explored as a topical drug delivery vehicle.Rheological analysis of the formulations showed that it was possible to produce a topical gel with a viscosity and the mechanical strength similar to that of the commercially available

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Clinical Applications of Transdermal Iontophoresis

Cited by 5 publications

References 74 publications

WITHDRAWN: Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue

WITHDRAWN: Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue

Delivery of drugs applied topically to the skin

Gellan gum fluid gels for topical administration of diclofenac

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