Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician

Constantinescu, Cătălin; Bodolea, Constantin; Pașca, Sergiu; Teodorescu, Patric; Dima, Delia; Rus, Ioana; Tat, Tiberiu; Achimaș-Cădariu, Patriciu; Tănase, Alina; Tomuleasa, Ciprian; Einsele, Hermann

doi:10.3390/jcm8060884

Cited by 16 publications

(12 citation statements)

References 124 publications

(125 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite divergent data from various studies, CRP is used to assess acute exacerbations of chronic obstructive pulmonary disease or infectious complications of malignancies in order to reduce the use of antibiotics. Moreover, CRP has been included in point-of-care diagnostic devices [ 30 , 31 ]. Serum procalcitonin is used in many hospitals as a biomarker of sepsis and could differentiate the most common aetiologies.…”

Section: Discussionmentioning

confidence: 99%

Clinical, Pathological and Microbiological Evaluation of Diabetic Foot Syndrome

et al. 2020

View full text Add to dashboard Cite

Background and objectives: Diabetic foot ulcer (DFU) is one of the serious complications of diabetes, being related to frequent and long-term hospitalisation, reduced quality of life of the patient, amputations, a high rate of morbidity and mortality. The bacterial aetiology is complex, sometimes involving more than one pathogen, playing a major role in the infection prognosis and development of microbial resistance. This study evaluated the current state of the aetiology, clinical and pathological characteristics of DFU in a single diabetes centre in order to provide some specific measures to prevent it. Materials and Methods: This retrospective study was conducted on patients with diabetes mellitus (252 individuals diagnosed with DFU) between January 2018–December 2019. All participants were assessed based on their clinical characteristics, including complications of diabetes and pathological and microbiological evaluations. Results: The present research revealed that diabetic foot ulcer prevalence was higher in males than in females and higher in type 2 diabetic patients than in type 1 diabetic patients. The patients with diabetic foot ulcer were older, had a higher body mass index (BMI), longer diabetic duration and had more diabetic complications, such as retinopathy, diabetic polyneuropathy and diabetic kidney disease, than patients without diabetic foot ulceration. Conclusions: Taking into account all factors involved, including the aetiology and the antibiotic susceptibility pattern of these isolates, planning the suitable treatment options of patients is possible.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical, Pathological and Microbiological Evaluation of Diabetic Foot Syndrome

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Its levels in the plasma rose in severe bacterial, fungal and parasitic infections as well as sepsis [28]. Bacterial endotoxin played an important role in the induction process [29]. PCT was a parameter for the diagnosis and monitoring of bacterial inflammatory disease infections.…”

Section: Discussionmentioning

confidence: 99%

“…PCT was a parameter for the diagnosis and monitoring of bacterial inflammatory disease infections. Elevated PCT levels occurred in severe shock, systemic inflammatory response syndrome and multiple organ dysfunction syndrome [29]. PCT was closely related to the occurrence and process of severe bacterial and septicemic infections, and could accurately reflect whether the source of infection causing lesions (such as peritonitis) has been eradicated [30].…”

Section: Discussionmentioning

confidence: 99%

Nomogram prediction of surgical site infection of HIV-infected patients following orthopedic surgery: a retrospective study

et al. 2020

BMC Infect Dis

View full text Add to dashboard Cite

Background Surgical site infection (SSI) is a devastating complication of orthopedic surgery, related with increased morbidity and mortality. This study was performed with the aim to compare the SSI rate in human immunodeficiency virus HIV-positive patients, to identify other risk factors for SSI and to establish a nomogram model to predict the risk of SSI. Methods A total of 101 HIV-positive individuals following orthopedic surgery patients admitted to Beijing Ditan Hospital. Their characteristics were gathered. The univariate and multiple logistic regression analysis were performed to explore the risk factors of SSI. And the Nomogram prediction model was constructed and verified. Results The independent predictive factors of SSI included CD4 (Odds ratio [OR], 0.041; P = 0.040), erythrocyte sedimentation rate (ESR) (OR, 89.773; P = 0.030), and procalcitonin (PCT) (OR, 220.746; P = 0.006). The scoring nomogram model was as follows: Logit (SSI) = − 2.63589–0.00314*CD4 < 430.75 = 1) + 0.04695*(ESR < 17.46 = 1) + 2.93694*(PCT < 0.22 = 1). The area under the Receiver Operating Characteristic (ROC) curve was 0.946. The cutoff score was − 2.1026 with a sensitivity of 93.33% and a specificity of 84.88%. Conclusions CD4, ESR, PCT might affect the occurrence of SSI after orthopedic surgery. The nomogram model constructed in this study is helpful for predicting the probability of SSI.

show abstract

“…This is explained by the increasing efforts of personalizing chemotherapy treatment and supportive care that continuously adapts to initial diagnostic and progression of the disease, and which has resulted in better quality of life and higher overall survival (OS) rate in leukemic patients (8)(9)(10)(11). Despite, improvements made to the diagnosis and treatment of both forms of acute leukemia: lymphoblastic (ALL) and myeloid (AML), the CNS involvement is still limiting long-term treatment, remaining one of the most severe complication and the primary causes of mortality (12,13). CNS involvement is detected either at the initial diagnosis or it develops at relapse.…”

Section: Background On the Central Nervous Systems (Cns) Involvement mentioning

confidence: 99%

A narrative review of central nervous system involvement in acute leukemias

Deak¹,

Gorcea-Andronic²,

Sas³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each year more successful therapies are implemented. However, in a subset of cases the overall survival (OS) is still exceptionally low due to the infiltration of leukemic cells in the central nervous system (CNS) and the subsequent formation of brain tumors. The CNS involvement is more common in acute lymphocytic leukemia (ALL), than in adult acute myeloid leukemia (AML), although the rates for the second case might be underestimated. The main reasons for CNS invasion are related to the expression of specific adhesion molecules (VLA-4, ICAM-1, VCAM, L-selectin, PECAM-1, CD18, LFA-1, CD58, CD44, CXCL12) by a subpopulation of leukemic cells, called "sticky cells" which have the ability to interact and adhere to endothelial cells. Moreover, the microenvironment becomes hypoxic and together with secretion of VEGF-A by ALL or AML cells the permeability of vasculature in the bone marrow increases, coupled with the disruption of blood brain barrier. There is a single subpopulation of leukemia cells, called leukemia stem cells (LSCs) that is able to resist in the new microenvironment due to its high adaptability. The LCSs enter into the arachnoid, migrate, and intensively proliferate in cerebrospinal fluid (CSF) and consequently infiltrate perivascular spaces and brain parenchyma. Moreover, the CNS is an immune privileged site that also protects leukemic cells from chemotherapy. CD56/NCAM is the most important surface molecule often overexpressed by leukemic stem cells that offers them the ability to infiltrate in the CNS. Although

show abstract

Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician

Cited by 16 publications

References 124 publications

Clinical, Pathological and Microbiological Evaluation of Diabetic Foot Syndrome

Clinical, Pathological and Microbiological Evaluation of Diabetic Foot Syndrome

Nomogram prediction of surgical site infection of HIV-infected patients following orthopedic surgery: a retrospective study

A narrative review of central nervous system involvement in acute leukemias

Contact Info

Product

Resources

About