Clinical aspects and prognostic factors of leptospirosis in adults. Retrospective study in France

Abgueguen, P.; Delbos, V.; Blanvillain, Jerome; Chennebault, J.M.; Cottin, Jane; Fanello, S.; Pichard, É.

doi:10.1016/j.jinf.2008.06.010

Cited by 83 publications

(66 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cardiac involvement is usually subclinical, in milder forms, or masked by pulmonary hemorrhage, in severe leptospirosis 8 . Most of the reports have been clinical and tachycardia, electrocardiogram (ECG) abnormalities and refractory hypotension are the usual clinical manifestations 1,[10][11][12] . Pericardial effusion has been reported in patients with leptospirosis and advanced renal failure, suggesting a possible role for uremia in such patients 12 .…”

Section: IImentioning

confidence: 99%

“…The mechanism of cardiac involvement is poorly elucidated but may, as for kidney damage, result from toxic mechanisms associated with endotoxins, immunoallergic phenomena or direct damage by leptospira 1 . Disseminated intravascular coagulation can also play an important role in leptospirosis-associated cardiac involvement 9 .…”

Section: IImentioning

confidence: 99%

“…It is caused by species of Leptospira, and transmitted to humans by direct contact with infected tissues or contaminated urine, or indirectly by contact with contaminated water or soil. Mammalian reservoirs are the main distributors, and although rodents are the most important reservoir, other animals, including livestock, wild and domestic animals may excrete leptospires in their urine and, therefore, be a potential source of infection [1][2][3] . Leptospirosis is associated with occupational and recreational exposure, usually occurring as endemic in rural areas with outbreaks associated with floods 1,3 .…”

mentioning

confidence: 99%

“…Clinical spectrum is broad in leptospirosis. Multiple clinical presentations may occur and a wide variety of diseases may mimic different stages of leptospirosis 1 . Most patients will present a febrile self-limited condition, often misdiagnosed as influenza or dengue 1,2,4 .…”

mentioning

confidence: 99%

“…Multiple clinical presentations may occur and a wide variety of diseases may mimic different stages of leptospirosis 1 . Most patients will present a febrile self-limited condition, often misdiagnosed as influenza or dengue 1,2,4 . Severe manifestations occur in approximately 5-10% of human infections and are characterized by the presence of jaundice, acute renal failure and hemorrhagic disorders, including severe pulmonary hemorrhage syndrome 1,2,5 .…”

mentioning

confidence: 99%

See 4 more Smart Citations

Atrial flutter complicating severe leptospirosis: a case report

Silva

Benevides

et al. 2013

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Cardiac disturbances are relatively common and electrocardiographic abnormalities may be found in more than 70% of patients with leptospirosis. We report the case of a 68 year-old male with severe leptospirosis who developed atrial flutter. Effective treatment was done with amiodarone. The patient became clinical stable, with complete recovery. Rigorous clinical observation and continuous electrocardiogram (ECG) monitoring may facilitate the identification of rhythm disorders, and thus prevent a probable fatal outcome, in severe cases of leptospirosis.

show abstract

Section: IImentioning

confidence: 99%

Section: IImentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Atrial flutter complicating severe leptospirosis: a case report

Silva

Benevides

et al. 2013

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

Fieberschübe, Kopf- und Gliederschmerzen sowie generalisierte Myalgien bei einem 27-jährigen Reiserückkehrer

2020

View full text Add to dashboard Cite

Der bisher gesunde 27-jährige Patient stellte sich notfallmäßig mit Fieberschüben, Kopf-und Gliederschmerzen sowie generalisierten Myalgien vor, die 5 Tage zuvor während der Heimreise aus Südfrankreich begonnen hatten. Er hatte in einer ländlichen Unterkunft in Meeresnähe übernachtet und Kontakt mit Meerwasser, jedoch nicht mit Süßwasser gehabt. In der Umgebung wurden Hühner gehalten und es herrschte eine gewisse Unordentlichkeit. Anamnestisch be-Abb. 1 8 Konventionelles Röntgenbild des Thorax mit bipulmonalen Konsolidierungen Abb. 2 8 Computertomographie des Thorax mit bipulmonalen Konsolidierungen

show abstract

Clinical and Imaging Manifestations of Hemorrhagic Pulmonary Leptospirosis: A State-of-the-Art Review

Marchiori

Lourenço

Setúbal

et al. 2010

Lung

View full text Add to dashboard Cite

Leptospirosis, a spirochetal zoonosis, is frequently unrecognized due to its manifestation as an undifferentiated fever. It is an emerging infectious disease that has changed from an occupational disease of veterinarians, farmers, butchers, and other animal handlers to a cause of epidemics in poor and decayed urban communities in developing countries. Humans are infected when mucous membranes or abraded skin come into direct contact with the urine of infected animals, especially rats and dogs. Mortality from severe leptospirosis is high, even when optimal treatment is provided. The diagnosis of leptospirosis is based on clinical findings, history of direct or indirect exposure to infected animals in endemic areas, and positive serological tests. It should be considered in the differential diagnosis of patients with febrile illnesses associated with pneumonitis and respiratory failure, especially when hemoptysis is present. Severe pulmonary involvement in leptospirosis consists primarily of hemorrhagic pneumonitis. In advanced cases, adult respiratory distress syndrome and massive pulmonary hemorrhage may occur. Chest radiographs show bilateral alveolar infiltrates and/or resemble viral pneumonia, bronchopneumonia, tuberculosis, adult respiratory distress syndrome, and other causes of pulmonary hemorrhage such as Goodpasture syndrome. High-resolution computed tomography scans may show nodular infiltrates, areas of consolidation, ground-glass attenuation, and crazy-paving patterns. Bronchoalveolar lavage and autopsy studies have suggested that ground-glass opacities and air-space consolidations are secondary to pulmonary hemorrhage. Although not specific, the presence of these computed tomography findings in a febrile patient with an appropriate history should suggest a diagnosis of leptospirosis.

show abstract

Clinical aspects and prognostic factors of leptospirosis in adults. Retrospective study in France

Cited by 83 publications

References 38 publications

Atrial flutter complicating severe leptospirosis: a case report

Atrial flutter complicating severe leptospirosis: a case report

Fieberschübe, Kopf- und Gliederschmerzen sowie generalisierte Myalgien bei einem 27-jährigen Reiserückkehrer

Clinical and Imaging Manifestations of Hemorrhagic Pulmonary Leptospirosis: A State-of-the-Art Review

Contact Info

Product

Resources

About