Clinical Aspects and Risk Factors of NosocomialStenotrophomonas maltophiliaBacteremia Episodes in a Turkish Intensive Care Unit

Abstract

Stenotrophomonas maltophilia is an important nosocomial pathogen with increasing frequency in recent years, especially in immunocompromised and clinically debilitated patients. The aim of this study is to describe the characteristics of 35 episodes of S. maltophilia bacteremia at Celal Bayar University hospital in Turkey over a 3-year period from January 2003 to December 2005. Cases were identified with microbiology laboratory records and clinical data were collected from the medical record of each patient. The source of bacteremia was central venous catheter (CVC) in 65.7% (23) and respiratory tract infection in 2.9% (1) of episodes while the source of bacteremia was unknown in 11 (31.4%) episodes of bacteremia. Factors significantly associated with mortality were age of > or =65 years, APACHE score of > or =16, the presence of the total parenteral nutrition, anemia, low creatinine clearance level and shock. The most sensitive antibiotic was found as trimethoprim-sulfamethoxazole (91.4%) in antibiotic susceptibility testing of the isolates. Susceptibilities of piperacillin-tazobactam and netilmicin which frequently used antibiotics as an empirical therapy were 62.8% and 68.6%, respectively.

Risk Factors and Outcomes of Stenotrophomonas maltophilia Bacteraemia: A Comparison with Bacteraemia Caused by Pseudomonas aeruginosa and Acinetobacter Species

“…Some studies suggest that bacteraemia due to SM was directly influenced by the conditions of each patient [15], [16], [26], [28], [31]. However, other studies have reported that the initial administration of the inappropriate antibacterial treatment to patients was a significant predictor of mortality [5], [17], [18], [32]–[33].…”

Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single‐center experience

“…Stenotrophomonas maltophilia has multi‐antibiotic resistance because of the natural possession of metallo‐β‐lactamase and cephalosporinase . Community‐acquired S. maltophilia infection is rare; however, under some risk conditions including a compromised health status , indwelling central venous catheter (CVC) or ventilation tube , exposure to broad‐spectrum antibiotics , intensive care unit (ICU) stay , and long‐term hospitalization , S. maltophilia infection can develop as severe bloodstream infection or pneumonia. Several previous studies have shown clinical characteristics and risk factors of S. maltophilia infection in patients with hematologic diseases after chemotherapy and allogeneic hematopoietic stem cell transplantation (allo‐HSCT) , but the details are not fully understood.…”

Dengue co-infection in a blood stream infection caused by Stenotrophomonas maltophilia: A case report

“…10 Old age, total parenteral nutrition, low creatinine clearance, anemia, thrombocytopenia, organ failure, and shock were identified as major factors significantly associated with mortality in S. maltophilia BSI in different studies. 10,11 Though S. maltophilia causes infections in predominantly nosocomial settings, community-acquired infections are occasionally reported.…”