Clinical aspects and treatment of hepatocellular carcinoma in north-eastern Poland

Łapiński, Tadeusz Wojciech; Tarasik, Aleksandr; Januszkiewicz, Marcin; Flisiak, Robert

doi:10.5114/ceh.2021.104631

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…Our ndings are closely related to those of Si et al, who found that serum levels of AFP and PIVKA-II in patients diagnosed with HCC due to HBV, but not selected for OLT, were signi cantly associated with tumor size (32). However, in our study, neither serum PIVKA-II nor AFP levels correlated with the number of tumours, in line with other studies such as that of Feng et al who found no correlation between serum PIVKA-II levels and the number of tumours (30), or Lapinski et al who also found no signi cant association between serum AFP levels and the number of tumour nodules (33).…”

Section: Discussionsupporting

confidence: 84%

Usefulness of PIVKA-II for Monitoring After Liver Transplantation in Patients With Hepatocellular Carcinoma

LÓPEZ

Mateos

LORENCIO

et al. 2022

Preprint

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The high morbidity and mortality of hepatocellular carcinoma (HCC) has encouraged the search for new biomarkers to be used alongside alpha-foetoprotein (AFP) and imaging tests. The aim of this study was to evaluate the clinical contribution of protein induced by vitamin K absence or antagonist-II (PIVKA-II) for HCC monitoring after liver transplantation (LT) and compare it with AFP, a routinely used tumour marker. A total of 46 HCC patients (Milan criteria) were enrolled in this study. Serum levels of PIVKA-II and AFP were measured before and after transplantation. Clinical features were determined for all the patients that were included. Significant correlations were found between PIVKA-II expression levels and some clinicopathological features, such as tumour size and number of pre-transplant transarterial chemoembolizations (TACEs). Serum levels of PIVKA-II and AFP decreased significantly after LT and increased in patients with tumour recurrence. Serum PIVKA-II levels may play an important role in predicting disease severity. Furthermore, monitoring PIVKA-II levels in HCC transplant recipients reflects the tumor early recurrence after transplantation and could be used, complementing AFP and imaging tests, as a novel biomarker of this pathology.

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Section: Discussionsupporting

confidence: 84%

Usefulness of PIVKA-II for Monitoring After Liver Transplantation in Patients With Hepatocellular Carcinoma

LÓPEZ

Mateos

LORENCIO

et al. 2022

Preprint

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“…In recent years, a decrease in the incidence of HBV has been recorded in endemic countries thanks to the vaccination of children. A further reduction in the incidence of HCC can be expected with the use of orally administered drugs inhibiting the HBV replication activity [ 62 ].…”

Section: Primary Liver Cancermentioning

confidence: 99%

“…A factor that hinders the characterization of focal lesions is the pathologically “remodeled” liver parenchyma. Interestingly, in the case of HCC, for the first time in the history of clinical oncology, in 2001, in Barcelona, the EASL expert panel established the criteria for the diagnosis of malignant neoplasm solely on the basis of imaging tests and additional examination of serum AFP (alpha fetoprotein) concentration without the need for histological verification [ 62 ].…”

Section: Primary Liver Cancermentioning

confidence: 99%

Chemokines in Primary Liver Cancer

Zajkowska

Mroczko

2022

IJMS

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The liver is responsible for extremely important functions in the human body. In the liver’s structure, we distinguish between connective tissue (stroma) and parenchyma, the latter of which is formed from the basic structural and functional units of the liver—hepatocytes. There are many factors, that negatively affect the liver cells, contributing to their damage. This may lead to fibrosis, liver failure and, in consequence, primary liver cancer, which is the sixth most commonly diagnosed malignancy and the fourth leading cause of cancer death worldwide. Chemokines are a large family of secreted proteins. Their main role is to direct the recruitment and migration of cells to sites of inflammation or injury. Some authors suggest that these proteins might play a potential role in the development of many malignancies, including primary liver cancer. The aim of this study was to evaluate and summarize the knowledge regarding liver diseases, especially primary liver cancer (HCC) and the participation of chemokines in the development of this malignancy. Chemokines involved in the initiation of this type of tumor belong mainly to the CC and CXC chemokines. Their significant role in the course of hepatocellular carcinoma proves their usefulness in detecting and monitoring the course and treatment in patients with this disease.

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“…Chronic carriers have a more than 100-fold increased relative risk of tumor development. Several mechanisms have been proposed to induce HCC using HBV [ 2 ]. HBV causes 80% of liver cancer cases and is the second most common carcinogen after smoking.…”

Section: Introductionmentioning

confidence: 99%

“…HBV causes 80% of liver cancer cases and is the second most common carcinogen after smoking. Babies born to e-positive mothers have approximately a 90% risk of becoming persistent carriers after perinatal infection, and preschoolers have a 30% risk [ 2 , 3 ]. Only 5% to 10% of adults become persistent carriers after infection.…”

Section: Introductionmentioning

confidence: 99%

HBV Infection-Related PDZK1 Plays an Oncogenic Role by Regulating the PI3K-Akt Pathway and Fatty Acid Metabolism and Enhances Immunosuppression

Chen

Wang

Zhu

et al. 2022

Journal of Immunology Research

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Background and Aim. Chronic hepatitis B virus (HBV) infection is the leading global cause of hepatocellular carcinoma (HCC). Few studies have been conducted concerning the HBV infection-related genes and their function. Methods. We compared differentially expressed genes (DGEs) in HBV-positive and -negative tumor samples and conducted a Spearman correlation study between the DGEs and HBV titers within The Cancer Genome Atlas (TCGA). Moreover, we validated the results of our in-house samples. Results. In this study, we discovered a series of genes that correlated statistically with HBV infection based on the TCGA database. These genes were related to increased inflammation and some oncogenic signaling pathways via Gene Set Enrichment Analysis (GSEA). PDZK1 is an ideal gene, which mostly relates positively to HBV infection; moreover, it is overexpressed in human HCC, especially in those HBV-infected HCCs. After analyzing the TCGA data and performing a verification study using our own samples, PDZK1 expression was investigated to be significantly associated with PI3K-Akt signaling and fatty acid metabolism. Further, single-sample GSEA analysis of tumor immune cell infiltration gene sets revealed that high PDZK1expression in HCC tissues was significantly associated with increased tumor-associated macrophages (TAMs) and regulatory T cells(Tregs). Conclusions. PDZK1 is an HBV infection-related gene, which plays oncogenic roles, possibly due to enhancing PI3K-Akt, fatty acid usage in tumor cells and TAMs, and Treg-induced immunosuppression.

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Clinical aspects and treatment of hepatocellular carcinoma in north-eastern Poland

Cited by 8 publications

References 20 publications

Usefulness of PIVKA-II for Monitoring After Liver Transplantation in Patients With Hepatocellular Carcinoma

Usefulness of PIVKA-II for Monitoring After Liver Transplantation in Patients With Hepatocellular Carcinoma

Chemokines in Primary Liver Cancer

HBV Infection-Related PDZK1 Plays an Oncogenic Role by Regulating the PI3K-Akt Pathway and Fatty Acid Metabolism and Enhances Immunosuppression

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