Clinical aspects of 2541 patients with second stage human African trypanosomiasis

“…Chronic and intermittent fever, headache, pruritus, lymphadenopathy and, to a lesser extent, hepato-splenomegaly are the leading signs and symptoms of the first stage. In the second stage sleep disturbances and neuro-psychiatric disorders dominate the clinical presentation and fever is rarely present [13,14].…”

Section: Endemic Countriesmentioning

confidence: 99%

Human African trypanosomiasis in endemic populations and travellers

Blum

Neumayr

Hatz

2011

Eur J Clin Microbiol Infect Dis

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“…Studies looking at clinical aspects of HAT have focused mainly on central nervous system signs and symptomatology (38). Therefore, whether cardiac signs and symptoms in HAT are being overshadowed by predominant neurological involvement or whether their prevalence is truly low is an important question that remains unanswered.…”

Section: Parasites That Preferentially Involve the Myocardium Or Causmentioning

confidence: 99%

Cardiac Involvement with Parasitic Infections

et al. 2010

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SUMMARY Parasitic infections previously seen only in developing tropical settings can be currently diagnosed worldwide due to travel and population migration. Some parasites may directly or indirectly affect various anatomical structures of the heart, with infections manifested as myocarditis, pericarditis, pancarditis, or pulmonary hypertension. Thus, it has become quite relevant for clinicians in developed settings to consider parasitic infections in the differential diagnosis of myocardial and pericardial disease anywhere around the globe. Chagas' disease is by far the most important parasitic infection of the heart and one that it is currently considered a global parasitic infection due to the growing migration of populations from areas where these infections are highly endemic to settings where they are not endemic. Current advances in the treatment of African trypanosomiasis offer hope to prevent not only the neurological complications but also the frequently identified cardiac manifestations of this life-threatening parasitic infection. The lack of effective vaccines, optimal chemoprophylaxis, or evidence-based pharmacological therapies to control many of the parasitic diseases of the heart, in particular Chagas' disease, makes this disease one of the most important public health challenges of our time.

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“…In the first stage, the parasites reside in the blood and the lymphatic system. In the second stage, the parasites cross the blood-brain barrier (BBB) and spread the infection to the central nervous system (CNS), leading to neurological and psychiatric disorders, including irregular and fragmented sleeping patterns, behavioral changes, motor weakness, coma, and ultimately death (4).…”

mentioning

confidence: 99%

In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness

Wenzler

Yang

Patrick

et al. 2014

Antimicrob Agents Chemother

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f African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a dipyridylbenzene analogue of DB829, is the second simple diamidine found to cure mice with central nervous system infections by a parenteral route of administration. 28DAP010 showed efficacy similar to that of DB829 in dose-response studies in mouse models of first-and second-stage African sleeping sickness. The in vitro time to kill, determined by microcalorimetry, and the parasite clearance time in mice were shorter for 28DAP010 than for DB829. No cross-resistance was observed between 28DAP010 and pentamidine on the tested Trypanosoma brucei gambiense isolates from melarsoprol-refractory patients. 28DAP010 is the second promising preclinical candidate among the diamidines for the treatment of second-stage African sleeping sickness.

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Clinical aspects of 2541 patients with second stage human African trypanosomiasis

Cited by 145 publications

References 4 publications

Human African trypanosomiasis in endemic populations and travellers

Human African trypanosomiasis in endemic populations and travellers

Cardiac Involvement with Parasitic Infections

In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness

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