Clinical aspects of hantavirus infections in Bulgaria

Christova, Iva; Pishmisheva, Maria; Trifonova, Iva; Vatev, Nikolay Todorov; Stoycheva, M.; Tiholova, M.; Igova, D.; Baev, M.; Karagyaurova, R.; Prokopova, U.

doi:10.1007/s00508-017-1174-2

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…Abnormal laboratory test results returned to normal within approximately 3-5 days, with a range of 1-13 days. These findings seem to be similar to those of other reported patients infected with PUUV (Christova et al, 2017;Golovljova et al, 2007;Latus et al, 2015;Skarphedinsson, Thiesson, Shakar, & Tepel, 2015;Vilibic-Cavlek et al, 2017).…”

Section: çElebisupporting

confidence: 92%

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Çelebi

Öztoprak

Öktem

et al. 2019

Zoonoses and Public Health

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Background Some of the hantavirus species in Euro‐Asia cause haemorrhagic fever with renal syndrome (HFRS) in humans. The first documented human hantavirus infection in Turkey was diagnosed in 2009. This report describes the dynamics of the first hantavirus outbreak that emerged in humans in the Western Black Sea Region of Turkey. Methods All the suspected cases of hantavirus infection were admitted to the Infectious Diseases and Clinical Microbiology Department at the Zonguldak Bülent Ecevit University Hospital in Zonguldak, Turkey. The patients were carefully interviewed, examined and evaluated using routine laboratory tests and hantavirus diagnostic tools. Hantavirus‐reactive antibodies (IgM and IgG) in serum samples were detected via enzyme immune assay (EIA) and immunofluorescence assay (IFA) in the acute and convalescence stages of the disease. The presence of hantavirus ribonucleic acid (RNA) was analysed via reverse transcription polymerase chain reaction (RT‐PCR) in serum and urine samples. A focus reduction neutralization test (FRNT) was performed to confirm specific hantavirus serotypes. In addition, a case–control study was conducted to identify possible risk factors for hantavirus transmission in the outbreak area. A control group was composed of asymptomatic individuals who were seronegative for hantavirus IgM and IgG and living in the outbreak area. Results A total of 55 suspected cases of hantavirus infection were admitted to the inpatient clinic between February and June of 2009. Twenty‐four patients were diagnosed with acute HFRS via EIA or IFA. In 22 of the 24 infected patients, Puumala virus (PUUV) was identified as the causative hantavirus type by detecting IgM in the acute stage and an increase in the IgG level in follow‐up serum samples. PUUV was also verified as the infecting agent by FRNT in two of the 24 cases. Among the 24 laboratory‐confirmed HFRS cases, 21 (87.5%) were males and 3 (12.5%) were females, and the mean age was 45.92 years (standard deviation ± 16.90 years). Almost all these individuals were living in villages or rural areas. The 24 HFRS cases were matched with 26 healthy controls for statistical analyses and according to binary logistic regression analysis, and dealing with rodent control activities in gardens or in annexes of their homes (p = 0.021 and Odds ratio [OR] = 17.11) and being male (p = 0.019 and OR = 22.37) were detected as statistically significant risk factors for hantavirus infection. The most commonly observed clinical complaints were fatigue (95.8%), shivering (91.7%), fever (87.1%), headache (70.8%) and nausea (70.8%). Haemodialysis was required for four patients (16.7%). Except for the first case diagnosed with acute hantavirus infection, no patient died. The mean delay time to hospital admission from initiation of symptoms was 5.3 days, the mean duration of febrile days was 2.6 days, and the mean duration of hospital stay was 8.5 days. Conclusion Hantaviruses are circulating in Turkey and causing sporadic or epidemic infection in humans. Addit...

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Section: çElebisupporting

confidence: 92%

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Çelebi

Öztoprak

Öktem

et al. 2019

Zoonoses and Public Health

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“…Surprisingly, past PUUV infection was detected more often than DOBV in this study: PUUV seroprevalence rate was calculated as 2.3% versus 0.8% of DOBV. Recent study of clinically manifested hantavirus infections in Bulgaria revealed that infections in 16/23 (69.6%) patients with HFRS recognized for 2 years, 2013‐2014, were caused by DOBV while PUUV was shown as prevalent in Slovenia, Croatia, Bosnia, and Herzegovina .…”

Section: Discussionmentioning

confidence: 99%

Country‐wide seroprevalence studies on Crimean‐Congo hemorrhagic fever and hantavirus infections in general population of Bulgaria

Christova

Panayotova

Trifonova

et al. 2017

Journal of Medical Virology

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Crimean-Congo hemorrhagic fever (CCHF) and hantavirus infections are the two viral hemorrhagic fevers spread in Europe. To test actual circulation of CCHF virus (CCHFV) and hantaviruses in Bulgaria, we conducted country-wide seroepidemiological studies. Serum samples were collected prospectively from 1500 residents of all 28 districts in Bulgaria. CCHFV seroprevalence of 3.7% was revealed. Anamnesis for tick bites, contact with livestock, age over 40 years and residency in Haskovo district were found as risk factors. The highest CCHFV seroprevalence was observed in the known endemic districts in southeastern Bulgaria: Haskovo (28%) and Yambol (12%). Reactive samples were found in residents of 20 of the 28 districts in Bulgaria. In comparison with the previous studies, the data presented indicate that CCHFV increased substantially its circulation in the endemic regions and was introduced in many new areas. Hantavirus seroprevalence was based on results of the immunoblot and estimated as 3.1%. Surprisingly, contrary to all available data, Puumala virus seroprevalence rate was 2.3% versus 0.8% of Dobrava-Belgrade virus. Evidence for hantavirus IgG seropositivity was found in residents of 23 of the 28 districts in the country. The first hantavirus seroprevalence study in Bulgaria showed that Puumala virus is probably more wide-spread in the country than Dobrava-Belgrade virus.

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“…Secara umum, patogenesis Hantavirus melibatkan proses multifaktorial yang kompleks, termasuk strain virus, kontribusi respon imun, disfungsi keping darah, dan deregulasi fungsi sel barier endotelial atau predisposisi genetik terkait tipe Human Leucocyte Antigen, yang berpengaruh pada keparahan penyakit. Sebagai contoh infeksi virus Dobrava-Belgrade (DOBV) menyebabkan penyakit yang lebih parah dibanding Puumala virus (PUUV) (Christova et al 2017;Zupanc et al 2019).…”

Section: Mekanisme Penularanunclassified

“…Secara umum, Hantavirus menyebabkan dua penyakit yang berbeda pada manusia, yaitu Hantavirus Pulmonary Syndrome (HPS) atau Hantavirus Cardiopulmonary Syndrome (HCPS), serta Hemorrhagic Fever with Renal Syndrome (HFRS) (Christova et al 2017). Hantavirus menyebabkan infeksi meluas pada manusia yang melibatkan pembuluh darah perifer dan sangat mempengaruhi permeabilitasnya (Maes et al 2009).…”

Section: Manifestasi Penyakit Hantavirusunclassified

“…Infeksi virus Dobrava-Belgrade (DOBV) menyebabkan komplikasi hemoragi (Vapalahti et al 2003). Infeksi DOBV menyebabkan arthromyalgia, sakit kepala dengan derajat sedang hingga parah, asthenoadynamia atau kelelahan parah, sakit perut, muntah, hipotensi, kelainan sistem syaraf, pembesaran ginjal, leukopenia, dan tingginya level kreatin darah (Christova et al 2017). Infeksi virus Seoul (SEOV) dari kasus yang terjadi di Indonesia dan Asia tenggara lainnya antara lain peningkatan enzim hati, limfopenia, trombositopenia dengan atau tanpa manifestasi hemoragi dan sindrom renalis (Lie et al 2018).…”

Section: Manifestasi Penyakit Hantavirusunclassified

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Hantavirus: Structure, Mechanism of Transmission of Disease, Development of Drugs and Vaccines, and Prevention in Indonesia

Assadah¹,

Sendow²,

Dharmayanti³

2020

WARTAZOA

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Hantavirus is a zoonosis transmitted by rodents and have been spread in various countries. Hantavirus causes Hantavirus Pulmonary Syndrome (HPS) and Haemorrhagic Fever with Renal Syndrome (HFRS) in humans is still receiving worldwide attention due to the high case fatality rate. Epidemiological studies have shown that Hantavirus is widespread globally, including in Indonesia. Indonesia is an archipelago and has a tropical climate, and is crossed by the equator so that it has an enormous diversity of animals, including those that become reservoirs of Hantavirus and other vulnerable animals. The high risk of developing Hantavirus in Indonesia does not rule out the possibility of a Hantavirus outbreak if no preventive action is taken. Until now there is no effective and safe vaccine or treatment for Hantavirus. Various development efforts continue to be made to obtain an appropriate and safe vaccine to prevent and stop the spread of Hantavirus. This paper discusses Hantavirus, including its structure and mechanism of transmission, the current situation of Hantavirus in Indonesia and the efforts that can be made to prevent Hantavirus, including the development of vaccines and their drugs.

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Clinical aspects of hantavirus infections in Bulgaria

Abstract: The present report describes for the first time comparative analysis of epidemiological features, clinical manifestations and laboratory findings of DOBV and PUUV infections in Bulgaria.

Cited by 7 publications

References 16 publications

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Country‐wide seroprevalence studies on Crimean‐Congo hemorrhagic fever and hantavirus infections in general population of Bulgaria

Hantavirus: Structure, Mechanism of Transmission of Disease, Development of Drugs and Vaccines, and Prevention in Indonesia

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