Clinical Aspects of Infection with Methicillin-Resistant <i>Staphylococcus aureus</i> USA300 Strain, Generally Regarded as Community-Acquired, in Japan

A correlation between reduced susceptibilities to vancomycin and daptomycin among the MRSA isolates selected in mutant selection window of both vancomycin and daptomycin

“…It belonged to the same ST8 as USA300 clone of CA-MRSA prevalent in Europe and the United States [19,20]. The isolation rate of CA-MRSA in Japan is lower than those in foreign countries [21,22]. In the present study, MRSA-2318 strain isolated for the first time in the Tohoku district may be USA300 clone.…”

Investigation of the susceptibility trends in Japan to fluoroquinolones and other antimicrobial agents in a nationwide collection of clinical isolates: A longitudinal analysis from 1994 to 2016

“…CA-MRSA became a major concern worldwide in the early 2000s, thus we estimated the isolation frequency according to the susceptibility patterns to LVFX, MINO, and CAM. In Japan, the frequency of CA-MRSA is considered lower than in USA and Europe, where the major clone is USA300 [18], however, Nakamura et al reported 4 cases of CA-MRSA infection [19], and Yamaguchi et al reported an increase in the USA300 clone among patients suffering skin and soft tissue infections in Japan [20]. As such, continued surveillance is important.…”

Molecular epidemiologic study of community-associated methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin gene among family members in Japan

“…Especially in 2000s, PFGE strain type USA300-0114 was responsible for many outbreaks of invasive CA-MRSA infections in the United States [11]. In Japan, the first case of USA300-0114 infection was reported in 2008, and sporadic identification of USA300 was reported, but it is still considered as rare strain [12,13]. However, we found USA300 stain caused intrafamilial infections without history of travel abroad.…”