Clinical aspects of infection with Trichinella spp

Abstract

Isolated cases and outbreaks of infection with Trichinella spp. occur frequently throughout the world, sometimes resulting in fatalities. The clinical presentations of signs and symptoms are remarkably constant for most of the species of Trichinella, but in infections with Trichinella nativa and Trichinella britovi, classical symptoms of trichinellosis may be absent. It is important to be able to correlate the clinical presentation of trichinellosis with the life cycle of these helminths in order to make an accurate diagnosis. Knowledge of the epidemiology of the disease enables the physician to identify other potential cases, since most epidemics can be traced back to a common source of raw or undercooked meat. A comprehensive summary relating the most important clinical variables is presented graphically for easy reference to the text. Symptoms and signs are considered in relation to severity of infection. Laboratory findings and diagnostic techniques, including new modalities (e.g., DNA and antigen detection), are discussed. A discussion of treatment and preventive measures concludes our review.

Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats

“…When muscle cells were damaged, these enzymes released and increased their activities in the plasma. Thus, AST and CPK were regarded as musclespecific enzymes (Capo and Despommier 1996). In the present study, serum enzyme, AST and CPK, activities were significantly increased (P<0.001) in all treated groups in comparison with control-uninfected group.…”

Vater und Sohn mit Muskelschmerzen und Kraftlosigkeit

“…1 Woche folgenden, parenteralen Phase erfolgt die Generalisierung der neuentwickelten Larven, es resultieren u.a. diffuse Myalgien, betont im Gesichtsbereich lokalisierte entzündliche Ödeme und Fieber [6,7,11,12,15].…”

“…Hämagglutinations-Test erfolgen [6,12]. Dabei sind die jeweiligen zeitlichen Nachweisgrenzen zu beachten.…”

“…Erkrankung bestehen Meldepflicht. [5,7,6,12]. Bei der Trichinose handelt es sich um eine potentiell tödlich verlaufende Erkrankung, insbesondere in Fällen mit später Diagnose bzw.…”

“…erst nach artifizieller Digestion der Muskelprobe. Eine andere Methode besteht im histopathologischen Nachweis der Larven[6,12]. Wie in unserem Fall kann dieser durch die ungleichmäßige Verteilung der Larven im Muskelgewebe erschwert werden, so daß eine quantitative Aufarbeitung in Stufenschnitten empfehlenswert ist.…”