2005
DOI: 10.1007/s00535-005-1646-4
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Clinical aspects of intraductal papillary mucinous neoplasm of the pancreas

Abstract: Intraductal papillary mucinous neoplasm (IPMN) is a spectrum of neoplasia in the pancreatic duct epithelium characterized by cystic dilation of the main and/or branch pancreatic duct. According to the site of involvement IPMNs are classified into three categories, i.e., main duct type, branch duct type, and combined type. Most branch duct IPMNs are benign, whereas the other two types are often malignant. A large size of branch duct IPMN and marked dilation of the main pancreatic duct indicate the presence of a… Show more

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Cited by 127 publications
(105 citation statements)
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“…1 Intraductal papillary mucinous neoplasms are considered to progress sequentially from adenoma to carcinoma in a stepwise fashion. 2 Compared with non-invasive intraductal papillary mucinous neoplasms, invasive carcinomas derived from intraductal papillary mucinous neoplasms have a poor prognosis. 3 Intraductal papillary mucinous neoplasms are also classified into several subtypes based on morphological features and immunohistochemical findings of mucin expression regardless of the histological grade, including gastric type, intestinal type, pancreatobiliary type, and oncocytic type.…”
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confidence: 99%
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“…1 Intraductal papillary mucinous neoplasms are considered to progress sequentially from adenoma to carcinoma in a stepwise fashion. 2 Compared with non-invasive intraductal papillary mucinous neoplasms, invasive carcinomas derived from intraductal papillary mucinous neoplasms have a poor prognosis. 3 Intraductal papillary mucinous neoplasms are also classified into several subtypes based on morphological features and immunohistochemical findings of mucin expression regardless of the histological grade, including gastric type, intestinal type, pancreatobiliary type, and oncocytic type.…”
mentioning
confidence: 99%
“…However, intestinal-type intraductal papillary mucinous neoplasms tend to be found in high-grade intraductal papillary mucinous neoplasms of borderline neoplasm and carcinoma, notably colloid carcinoma. 2 According to the International Consensus Guidelines, 6 all main duct intraductal papillary mucinous neoplasms, including mixed type, and branch duct intraductal papillary mucinous neoplasms suspected of malignancy are candidates for surgery. Although some clinical and imaging features, including dilatation of the main pancreatic duct, the presence of intramural nodules, cyst size of more than 30 mm, and the presence of symptoms, have been shown to predict malignancy in intraductal papillary mucinous neoplasms, it is sometimes difficult to accurately diagnose the grade of malignancy of intraductal papillary mucinous neoplasms preoperatively by these predictors.…”
mentioning
confidence: 99%
“…Intraductal papillary mucinous neoplasms (IPMNs) show a wide spectrum of histological differentiation from hyperplasia, adenoma and borderline neoplasm to carcinoma, and the existence of an adenoma-carcinoma sequence is documented. [1][2][3] IPMNs are considered to be precursors of invasive cancer of either tubular ductal adenocarcinoma or colloid (mucinous noncystic) carcinoma. [4][5][6][7] Recently, subclassification of IPMNs, based on morphological features and immunohistochemical profiles, has been proposed.…”
mentioning
confidence: 99%
“…[8][9][10] IPMNs arising from branch ducts often show gastric-type differentiation and have a less aggressive clinical course. 1,9 Pancreatobiliary-type IPMNs show severe atypia corresponding to in situ carcinoma and is often associated with an invasive tubular type of ductal adenocarcinoma. These findings suggest that each type of IPMN follows a different pathway of carcinogenesis.…”
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confidence: 99%
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