Clinical aspects of protein glycation

Galiniak, Sabina; Krawczyk-Marć, Izabela; Sęk-Mastej, Anna; Leksa, Natalia; Biesiadecki, Marek; Orkisz, S

doi:10.15584/ejcem.2017.3.10

Cited by 5 publications

(3 citation statements)

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“…Currently, resveratrol research spans a large spectrum of areas and is a subject of considerable scientific attention, in particular, investigations of its biological activity and the effects of resveratrol administration in numerous diseases in both clinical and nonclinical trials (Scheme 2). stimulation of inappropriate cellular activity (Singh et al, 2001;Galiniak et al, 2017). Glycation produces highly reactive dicarbonyl compounds such as methylglyoxal and glyoxal, which are key precursors to the formation of AGEs.…”

Section: Introductionmentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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Resveratrol is a polyphenol which is abundant in grape skin and seeds. Sources of resveratrol in food also include wine, berries, and peanuts. This compound displays many properties including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, as well as aging. Due to the fact that resveratrol is generally well-tolerated, it is believed to be a promising compound in preventing many diseases such as diabetes and associated complications. Unfortunately, this compound exhibits low bioavailability and solubility. The aim of this review is to summarize recent information from in vitro and in vivo studies on animals and humans on the multiple effects of resveratrol on health and benefits of its intake.

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Section: Introductionmentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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“…Glycation is a non-enzymatic reaction between proteins and reducing sugars, leading to the formation of advanced glycation end products (AGEs), whose accumulation causes cell and tissue damage, as a result of lipid peroxidation, endothelial dysfunction, changes in protein structure, and stimulation of inappropriate cellular activity [ 30 , 31 ]. Recent reports suggest that increased glycation is associated with a higher prevalence of diabetes and related complications [ 32 , 33 ], myasthenia gravis [ 34 ], and neurodegenerative diseases [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox

et al. 2020

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Resveratrol (RSV) is well known for its many beneficial activities, but its unfavorable physicochemical properties impair its effectiveness after systemic and topical administration; thus, several strategies have been investigated to improve RSV efficacy. With this aim, in this work, we synthesized a novel RSV triester with trolox, an analogue of vitamin E with strong antioxidant activity. The new RSV derivative (RSVTR) was assayed in vitro to evaluate its antioxidant and anti-glycation activity compared to RSV. RSVTR chemical stability was assessed at pH 2.0, 6.8, and 7.2 and different storage temperatures (5 °C, 22 °C, and 37 °C). An influence of pH stronger than that of temperature on RSVTR half-life values was pointed out, and RSVTR greatest stability was observed at pH 7.2 and 5 °C. RSVTR showed a lower antioxidant ability compared to RSV (determined by the oxygen radical absorbance capacity assay) while its anti-glycation activity (evaluated using the Maillard reaction) was significantly greater than that of RSV. The improved ability to inhibit the glycation process was attributed to a better interaction of RSVTR with albumin owing to its increased topological polar surface area value and H-bond acceptor number compared to RSV. Therefore, RSVTR could be regarded as a promising anti-glycation agent worthy of further investigations.

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“…The in vivo accumulation of advanced glycation end products (AGEs), resulting from non-enzymatic reactions between proteins and reducing sugars (glycation), may lead to different cell and tissue damages [54,55]. As recent reports pointed out the effectiveness of several polyphenols in counteracting AGEs formation [56], we thought it would be interesting to evaluate the anti-glycation activity of the saffron extracts under investigation.…”

Section: Antiglycation Activitymentioning

confidence: 99%

Evaluation of Crocin Content and In Vitro Antioxidant and Anti-Glycation Activity of Different Saffron Extracts

Ronsisvalle,

Panico,

Santonocito

et al. 2023

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Crocin, a glycoside carotenoid that exhibits several health benefits, is mainly obtained from saffron (Crocus sativus L.), whose quality and content of phytochemicals can be strongly affected by environmental conditions. Therefore, in this work, the crocin content and in vitro antioxidant activity of saffron extracts obtained from three different varieties (Greek, Sicilian, and Iranian saffron) were assessed. Crocin content in saffron extracts was quantified via ultra-performance liquid chromatography coupled with mass spectrometry. The antioxidant activity of saffron extracts was evaluated using the oxygen radical absorbance capacity (ORAC) assay and nitric oxide (NO) radical scavenging test. The Maillard reaction was used to assess anti-glycation activity. Although the Sicilian and Iranian saffron extracts contained higher amounts of crocin (128 ± 6 ng/mL and 126 ± 4 ng/mL, respectively) compared to the Greek extracts (111 ± 2 ng/mL), ORAC values (50.9 ± 0.5) and % NO inhibition (35.2 ± 0.2) were higher for the Greek variety, which displayed a total phenolic content about two-fold greater than that of the other two extracts. Sicilian and Greek saffron had similar anti-glycation activities, while Iranian saffron was less effective. These results suggest that the antioxidant activity of saffron extracts could be ascribed to their naturally occurring complex mixture of phytochemicals, deserving further investigation as supplements to prevent pathological conditions induced by radical species.

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Clinical aspects of protein glycation

Cited by 5 publications

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Health benefits of resveratrol administration

Health benefits of resveratrol administration

In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox

Evaluation of Crocin Content and In Vitro Antioxidant and Anti-Glycation Activity of Different Saffron Extracts

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