Clinical Assessment of Liver Size in Normal Children

Younoszai, M. K.; Mueller, S.

doi:10.1177/000992287501400410

Cited by 18 publications

(5 citation statements)

References 4 publications

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“…In addition, there are no more recent data on the liver span in older children to allow for proper comparison. Accordingly, the difference between our results and those in available literature[ 11 13 ] may be due to sampling, variation between generations, or to ethnic variation between populations.…”

Section: Discussioncontrasting

confidence: 96%

“…However, the mean liver span in our study is 1–2 cm lower than that reported in an older study by Younoszai et al . [ 13 ] Again, their study used a different technique (percussion of the lower border) than ours in a group of children aged from 5 to 13 years. It is difficult to compare the results of the above studies with these in the present report because of differences in the type of samples that are more selective, smaller in size, and much older than ours (more than a difference of 20 years).…”

Section: Discussionmentioning

confidence: 94%

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Liver size in Saudi Children and adolescents

Mouzan

Salloum

Herbish

et al. 2009

Saudi J Gastroenterol

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Background/Aim:To examine the liver size in Saudi children and adolescents.Methods:A large sample of children was selected from the general population by multistage random probability sampling for the assessment of physical growth. A random subsample of children–newborns to 18 years old–was taken from this larger sample for this study. Liver size below the costal margin and liver span along the midclavicular line were determined by physicians. Data were analyzed using SPSS software and medians and standard deviations were calculated.Results:Between 2004 and 2005, 18 112 healthy children up to 18 years of age were examined. All were term and appropriate for gestational age. There were 9 130 boys and 8 982 girls, yielding a nearly 1:1 male to female ratio. The maximum palpable liver size below the costal margin was 2.4 cm. The median and + 2 SD liver span at birth were 4 and 6.9 cm, respectively. There was no difference in the liver span between boys and girls of up to 60 months of age. Thereafter, a difference could be seen increasing with age, with girls having smaller liver spans than boys.Conclusion:This manuscript reports the liver size in Saudi children and adolescents. The data should help physicians in the interpretation of liver size determined by physical examination of children and adolescents.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 94%

Liver size in Saudi Children and adolescents

Mouzan

Salloum

Herbish

et al. 2009

Saudi J Gastroenterol

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“…When palpable, the liver edge was most commonly within 0.5 em of the change in percussion note. Surprisingly, the authors showed average liver span in children between the ages of 6 months and 12 years as ap-proximately 2.5-3 cm less th an the average span reported by others (7,10). They related this difference to the method of examination, that is, percussion of the lower border of the liver.…”

mentioning

confidence: 77%

“…No significant difference between mean liver spans in different ethnic groups or between males and females has been found in the studies reviewed. A compilation of data from four recent studies (7,10,12,13) of liver size is given in Table 1. From these, it is possible to determine 95% confidence limits for the mean values given in the table.…”

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confidence: 99%

Assessment of Liver Size in Normal Infants and Children

Naveh,

Berant

1984

J. pediatr. gastroenterol. nutr.

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“…The liver span was recorded as the distance between the upper border of the liver, determined by percussion, and the lower border, determined by palpation, both in the midclavicular line. Hepatomegaly was defined as "moderate" when the liver span was increased by more than 30% over the usual size for age (4,5), and as "marked" when the span was increased by more than 50%. None of the patients with hepatomegaly had any medication other than steroids before or during the period of study.…”

Section: Methodsmentioning

confidence: 99%

Hepatomegaly Following Short‐Term High‐Dose Steroid Therapy

Iancu,

Shiloh,

Dembo

1986

J. pediatr. gastroenterol. nutr.

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SummaryChildren treated with large doses of corticosteroids were found to develop hepatomegaly within a few days. No relationship could be established between the condition for which steroids were given and the liver enlargement. Liver biopsy was thought to be indicated, and thus was performed in three children because of diagnostic uncertainty. The light and electron microscopic examinations revealed normal liver architecture, without edema, sinusoid engorgement, or inflammatory changes. The hepatocytes were distended by increased amounts of glycogen. In a pattern reminiscent of some glycogen storage diseases, mitochondria and other cytosol components were displaced toward the cell membrane or around the nucleus, which occasionally contained glycogen. Moderate sinusoidal compression, interhepatocytic free glycogen particles, and mild increase in lipid droplets were also found. It is concluded that the hepatomegaly noted in patients given short‐term, high‐dosage steroid therapy is due to excessive glycogen accumulation within parenchymal cells. This finding is in accordance with observations in animals, as well as with biochemical studies demonstrating hepatocytic glycogen deposition after steroid therapy. Being benign and reversible, early hepatomegaly following administration of high‐dose corticosteroids should not influence the initial therapeutic plan required by the basic disease.

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Clinical Assessment of Liver Size in Normal Children

Cited by 18 publications

References 4 publications

Liver size in Saudi Children and adolescents

Liver size in Saudi Children and adolescents

Assessment of Liver Size in Normal Infants and Children

Hepatomegaly Following Short‐Term High‐Dose Steroid Therapy

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