Clinical assessment of optic nerve disorders

Riordan-Eva, Paul

doi:10.1038/sj.eye.6701575

Cited by 30 publications

(21 citation statements)

References 68 publications

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“…A reduction in visual acuity is often a late manifestation of papilloedema [32], whereas loss of colour vision can be an early feature in optic nerve compression [32]. Colour vision testing is hence an important tool which we recommend as part of routine visual function monitoring in IIH.…”

Section: Discussionmentioning

confidence: 99%

Optic nerve sheath fenestration for idiopathic intracranial hypertension: A seven year review of visual outcomes in a tertiary centre

Ebube

Lakhani

Burns

et al. 2015

Clinical Neurology and Neurosurgery

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Section: Discussionmentioning

confidence: 99%

Optic nerve sheath fenestration for idiopathic intracranial hypertension: A seven year review of visual outcomes in a tertiary centre

Ebube

Lakhani

Burns

et al. 2015

Clinical Neurology and Neurosurgery

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“…29 The dynamic range of the Ishihara plate test is quite restricted and the degree of difficulty of many plates is similar, yet it is still routinely used as a screening tool in suspected optic neuritis. 30,31 The C test was designed to overcome some of these limitations as a screening tool but any tritan plate test will face more problems than a similar red/green test if used for long term follow up. The LOCS III score may need to be revised, especially in older patients, and the distribution of Lutein and Zeaxanthin in the macula may alter as a result of dietary changes.…”

Section: Discussionmentioning

confidence: 99%

The “C test” for tritan discrimination

Franzco¹,

Doba²

2017

Color Research & Application

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The aim of this study was to develop and evaluate a clinical standard capable of generating ordinal measures of monocular tritan discrimination. A novel pseudoisochromatic plate test was developed, called the "C test." It contains 10 progressively desaturated plates arranged in perceptually distinct steps that provide a standard for analyzing the threshold for tritan discrimination. The most difficult plate that can be detected is the "C score." Relevant diagnostic findings including the C score, Logmar acuity, Pelli-Robson score, and LOCS III lens grading were prospectively recorded in 568 eyes. A total of 355 normal eyes were selected for statistical analysis. The correlations between C score, Logmar acuity, and Pelli-Robson score with LOCS III grading were analyzed with Spearman rank analysis. The strongest correlations were between the Logmar acuity with posterior subcapsular cataract (PSC) (0.68), the C score with nuclear colour (NC) (-0.58), and the Logmar acuity with NC (0.57). The lower normal limit for the C score was 9 in pseudophakes and phakic eyes with NC < 3, 7 for eyes with NC 5 3, but undetermined for eyes with NC > 3. A comparison of C score distribution between three distinct age ranges of pseudophakic eyes (n 5 136) showed no significant variation (P 5 .486). The Spearman rank correlation between C score and Logmar acuity was 0.028, and between C score and Pelli-Robson score was 0.012. The normal limit for the C score used under 800 Lux is 9 when NC < 3 and 7 when NC 5 3 in all age groups. K E Y W O R D Sacquired dyschromatopsias, C test, nuclear color, pseudoisochromatic plate test, tritan discrimination | I NT ROD UCTI ONClinical vision testing consists mainly of central achromatic resolution, peripheral luminance contrast, and red/green chromatic discrimination. These tests explore the parvocellular and magnocellular pathways but leave the koniocellular pathway largely undetermined. The Lanthony tritan album was an attempt to fill an apparent clinical need for a rapidly administered inexpensive plate test of tritan threshold, but it has serious limitations. These include a high false positive rate due to having only four choices per trial, a small range of only five plates, and inconsistent colorimetric properties between editions. 9Most colour-sorting tests use "foveal" stimuli because they are designed around the 28 field of the 1931 CIE standard observer; however, the central 0.358 of the human fovea contains no short wavelength sensitive (S) cones, and the 58 |

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“…Any toxic effect on the optic nerve may result in various visual field defects, including central and/or paracentral scotoma. 17 Standard automated perimetry is the current gold standard for assessing visual function in optic nerve diseases. Studies have shown, however, that patients can lose up to 40% of retinal ganglion cells before developing visual field defects detectable by SAP.…”

Section: Discussionmentioning

confidence: 99%

Structural and Functional Assessment in Patients Treated with Systemic Isotretinoin Using Optical Coherence Tomography and Frequency-Doubling Technology Perimetry

Bakbak¹,

Gedik²,

Köktekir³

et al. 2013

Neuro-Ophthalmology

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A causal association between central nervous system neuropathy and oral isotretinoin has been reported. In this study we aimed to assess retinal nerve fibre layer (RNFL) thickness and visual field changes in patients treated with systemic isotretinoin. Thirty-nine patients treated with 1 mg/kg daily oral isotretinoin were enrolled in this prospective clinical trial. All patients underwent complete ophthalmologic assessment before treatment, on day 60, and 3 months after completion of treatment. RNFL thickness measurements were performed with Stratus optical coherence tomography. Functional testing included frequency-doubling technology perimetry and Humphrey field analyser. Main outcome measures were average RNFL thicknesses and visual field indices (mean deviation, pattern standard deviation). Measurements of RNFL thickness showed no statistically significant change between the three measurements (p = 0.180). No statistically significant differences were observed in the frequency-doubling technology indices (mean deviation and pattern standard deviation, p = 0.066 and p = 0.103, respectively) and in the Humphrey field analyser indices (mean deviation and pattern standard deviation, p = 0.091 and p = 0.087, respectively) at day 60 of treatment or 3 months after the cessation of treatment. In this study of 39 patients, systemic use of isotretinoin (1 mg/kg daily) does not cause a statistically significant change in peripapillary RNFL thickness or visual field findings within the usage period, and within 3 months after cessation.

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Clinical assessment of optic nerve disorders

Cited by 30 publications

References 68 publications

Optic nerve sheath fenestration for idiopathic intracranial hypertension: A seven year review of visual outcomes in a tertiary centre

Optic nerve sheath fenestration for idiopathic intracranial hypertension: A seven year review of visual outcomes in a tertiary centre

The “C test” for tritan discrimination

Structural and Functional Assessment in Patients Treated with Systemic Isotretinoin Using Optical Coherence Tomography and Frequency-Doubling Technology Perimetry

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