Clinical Assessment of the Effectiveness of Three Different Controlled-release Drugs in the Management of Chronic Periodontitis: An In vivo Study

Vinothkumar, Thilla Sekar; Jalaluddin, Mohammad; Gopakumar, R; Jayachandran, Mahesh; Kumari, Deesha; Shivakumar, Shruti; Arora, Sandeep

doi:10.5005/jp-journals-10015-2005

Cited by 1 publication

(6 citation statements)

References 12 publications

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“…The study conducted by Jalaluddin, et al showed a lower mean probing depth was found in the tetracycline fiber group followed by metronidazole gel then the chlorhexidine chip group after one month of intervention [ 29 ]. Similar results were shown by a study conducted by Singh, et al that is, lower mean probing depths were found in the tetracycline fiber group than in the chlorhexidine chip group [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Jinger, et al conducted a study which showed that the mean probing depth in the chlorhexidine chip group was lower compared to the minocycline group after three months of intervention [ 32 ]. Different results are shown in the results of a study by Jalaluddin, et al which showed that the mean probing depth of the chlorhexidine chip group was higher than that of the tetracycline fiber group and the metronidazole gel group [ 29 ]. Based on the previous meta-analysis, other local antimicrobials showed better results than the chlorhexidine chip group after three months.…”

Section: Discussionmentioning

confidence: 99%

“…Jalaluddin, et al conducted a study comparing chlorhexidine chips, tetracycline fibers, and metronidazole gels. The results of the study of Jalaluddin, et al showed that the plaque index value of the chlorhexidine chip group was lower than the metronidazole gel group but higher than the tetracycline fiber group [ 29 ]. There are differences in the writing of the results reported therefore meta-analysis cannot be carried out.…”

Section: Discussionmentioning

confidence: 99%

“…Study conducted by Jhinger, et al showed that the mean plaque index in the chlorhexidine chip group was lower than that in the minocycline gel group after three months of intervention [ 32 ]. The study conducted by Jalaluddin, et al showed that the tetracycline fiber group produced the lowest mean plaque index after three months of intervention followed by chlorhexidine chip and metronidazole gel [ 29 ]. Based on the meta-analysis that has been done, the mean plaque index after three months of treatment showed no significant difference between the chlorhexidine chip group and other local antimicrobial groups (metronidazole, minocycline, and tetracycline).…”

Section: Discussionmentioning

confidence: 99%

“…Study by Jalaluddin, et al showed a lower gingival index value of the chlorhexidine chip group compared to the tetracycline fiber group and the metronidazole gel group after one month [ 29 ]. These results are similar to those in the study by Dheeraj, et al[ 36 ] The study by Reddy, et al showed that the gingival index in the chlorhexidine chip group after one month was higher than the tetracycline fiber group [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of chlorhexidine gels and chips in Periodontitis Patients after Scaling and Root Planing: a systematic review and Meta-analysis

Annisa,

Sulijaya,

Tadjoedin

et al. 2023

BMC Oral Health

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Periodontal pockets are characteristic of periodontitis. Scaling and root planing is the gold standard for periodontitis treatment. Additional local antimicrobials are recommended in patients with a probing depth of ≥ 5 mm. This study aims to determine the effectiveness of chlorhexidine compared to other local antimicrobials in periodontitis. Searches were conducted using the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. Meta-analysis was performed on studies that met inclusion criteria after risk of bias assessment. Meta-analysis between chlorhexidine chips and other antimicrobials showed a mean difference in probing depth after one month of 0.58 mm (p < 0.00001) whereas after three months the mean difference in probing depth was 0.50 mm (p = 0.001), index plaque 0.01 (p = 0.94) and gingival index − 0.11 mm (p = 0.02). Between chlorhexidine gel and other antimicrobials showed a mean difference in probing depth of 0.40 mm (p = 0.30), plaque index of 0.20 mm (p = 0.0008) and gingival index of -0.04 mm (p = 0.83) after one month. Chlorhexidine chips were more effective on the gingival index than other antimicrobials after three months. The other antimicrobials were more effective than chlorhexidine chips on probing depth after one and three months, and than chlorhexidine gels on plaque index after one month.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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