Clinical assessment of the male fertility

Khatun, Amena; Rahman, Saidur; Pang, Myung-Geol

doi:10.5468/ogs.2018.61.2.179

Cited by 73 publications

(69 citation statements)

References 104 publications

(105 reference statements)

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“…Some factors such as radiation, smoking, varicocele, infection, urinary tract infection, environmental factors, nutritional deficiencies and oxidative stress contribute to male infertility ( Ahmadi et al ., 2016 ). Spermatogenesis and maturation processes can be affected by fluctuations in hormones, temperature, dietary balance, and exposure to toxins due to habits or environmental pol lutants (i.e., smoking, alcohol, cadmium, lead, radiation, pesticide, endocrine disruptive chemicals) ( Khatun et al ., 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Seminal profile of 23,504 patients over the years: 7 years of experience

Nogueira

Yoshida

Vilariño

et al. 2018

JBRA Assisted Reproduction

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ObjectiveTo evaluate the behavior of seminal parameters over the years - 2010 to May 2017.MethodsA retrospective study, carried out from January 2010 to May 2017, covering men who underwent sperm examination. Seminal parameters (volume, sperm concentration, motility, morphology, age and duration of infertility in years) of 23,504 men were evaluated. The groups were compared to each other to check whether there were changes to the seminal parameters in that period.ResultsThere was no change over the years considering the time of infertility, in an average of 3.78 years. The mean age of the patients was 36.53 years, with a trend of increase in 0.2 years. In relation to the volume of semen samples, the mean value was 3.29mL, with a decrease trend in 0.05mL. As for sperm concentration, the average was 34.37 million/mL, with a decrease trend of 1.0 million/mL. Progressive sperm motility showed an average of 47.27% and there was a decrease trend of 0.67%. Finally, sperm morphology presented an average of 2.79% of normal spermatozoa, with a decrease trend of 0.33%.ConclusionIt can be noted that over the years, the sperm quality of men looking for assisted reproduction clinics has tended to decrease in macroscopic and microscopic parameters (volume, sperm concentration, motility and morphology).

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Section: Discussionmentioning

confidence: 99%

Seminal profile of 23,504 patients over the years: 7 years of experience

Nogueira

Yoshida

Vilariño

et al. 2018

JBRA Assisted Reproduction

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“…Sperm parameters such as sperm count, sperm morphology, and motility are the standard means used to assess the quality of sperm. However, as it is now known these parameters do not adequately cover all of the causes of male infertility (Khatun, Rahman, & Pang, 2018), it is obvious that other problems occur outside the spermatogenesis process can also cause male infertility.…”

Section: Introductionmentioning

confidence: 99%

Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct

Zhang

Cui

et al. 2020

Journal Cellular Physiology

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Nowadays, abnormal loss of serine proteases appears very frequently in male patients with unexplained sterility. In fact, many testis-specific serine proteases, the largest family among the four protease families implicated in murine spermatogenesis, are indispensable for reproduction. In the present study, we demonstrate that the previously uncharacterized testis-specific serine protease TRYX5 (1700074P13Rik) is required for male fertility in mice. Tryx5 −/− male mice are sterile, yet they have normal spermatogenesis and normal sperm parameters. In vivo fertilization experiments showed that the fertilization rate of Tryx5 −/− sperm was almost zero. Sperm counting and analysis of paraffin sections of oviducts revealed that Tryx5 −/− sperm were unable to migrate into the oviduct, which is likely the cause of the observed infertility of the Tryx5 −/− male mice. Importantly, we also found that there was almost no mature ADAM3 present in Tryx5 −/− sperm and almost no ADAM3 precursor in Tryx5 −/− elongated spermatids of S13-16 stage, even though testes of Tryx5 −/− and wild type mice had the same amount of the total precursor ADAM3. Collectively, our results demonstrate that Tryx5 is essential for male fertility in mice and suggest that TRYX5 functions in the stability or localization of ADAM3 precursor in elongated spermatids S13-16 stage, thereby regulating the ability of sperm to migrate from the uterus into the ampulla of the oviduct, the site of fertilization. K E Y W O R D Sknockout mouse, male infertility, sperm migration, Tryx5

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“…It is well known that a multitude of factors, including sperm quality, can influence the success of IVF‐ET and ICSI cycles (Huang et al, ). In addition, compared with IVF‐ET, ICSI not only increases the extent of in vitro manipulation in the laboratory, but also increases the cost of assisted reproduction technology (ART), and may represent a genetic risk to the embryo (Khatun, Rahman, & Pang, ).…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that a multitude of factors, including sperm quality, can influence the success of IVF-ET and ICSI cycles (Huang et al, 2016). In addition, compared with IVF-ET, ICSI not only increases the extent of in vitro manipulation in the laboratory, but also increases the cost of assisted reproduction technology (ART), and may represent a genetic risk to the embryo (Khatun, Rahman, & Pang, 2018).A number of factors can reflect the quality of sperm samples, including volume, concentration, progressive motility, sperm DNA fragmentation rate, acrosomal enzyme activity and the acrosome reaction (Shu et al, 2013). These parameters are regulated by a combination of genetic, environmental, physiological and psychological factors.…”

mentioning

confidence: 99%

Cyclooxygenase 1 (COX1) as an indicator of sperm quality in humans

2020

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Sperm quality is important for in vitro fertilisation and embryo transfer and intracytoplasmic sperm injection in the treatment of human infertility. The purpose of this study was to screen for biomarkers that could evaluate sperm quality. We analysed semen samples in 172 fertile males; multivariate logistic regression analysis showed that the levels of COX1 (17.5 ng/ml) in seminal plasma may represent a useful biomarker for sperm quality (area under the curve: 0.745; sensitivity: 0.808; specificity: 0.722). Analysis indicated that the values of parameters related to sperm quality changed significantly (p < .05) between COX1 level ≥ 17.5 ng/ml group and COX1 level < 17.5 ng/ml group. Further analysis of two consecutive semen samples (1‐hr interval) from 48 subjects revealed that the first semen samples (COX1 levels ≥ 17.5 ng/ml) had a higher sperm concentration and a larger proportion of spermatozoa showing progressive motility, a lower rate of sperm DNA fragmentation and a lower proportion of spermatozoa undergoing the acrosome reaction spontaneously (p < .05); identical results were observed for the second semen samples. These data indicated that COX1 could be used as an indicator for sperm status and may be helpful for identifying better quality spermatozoa for artificial insemination.

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Clinical assessment of the male fertility

Cited by 73 publications

References 104 publications

Seminal profile of 23,504 patients over the years: 7 years of experience

Seminal profile of 23,504 patients over the years: 7 years of experience

Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct

Cyclooxygenase 1 (COX1) as an indicator of sperm quality in humans

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