Clinical behavior and management of three types of renal angiomyolipomas

Lee, Kun-Han; Tsai, Han-Yu; Kao, Yuting; Lin, Hsin-Chia; Chou, Yi-Chun; Su, Shih-Huan; Chuang, Cheng-Keng

doi:10.1016/j.jfma.2018.02.012

Cited by 18 publications

(36 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During standard ultrasound follow-up of our childhood cancer survivors (CCSs), sporadic renal angiomyolipomas without histological confirmation (SAMLs) were consistently detected. SAMLs are uncommon benign tumors most often affecting the kidney composed of blood vessels, smooth muscles, and adipose tissue in varying proportions 1–3 and are incidentally detected in older people by diagnostic imaging performed for various medical reasons. 4 , 5 They usually present as unilateral single lesions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is There a Higher Incidence of Sporadic Renal Angiomyolipoma in Childhood Cancer Survivors?

Kruseová

Gottfriedová

Zichová

et al. 2021

CLEP

View full text Add to dashboard Cite

Background Cancer treatment can cause various long-term side effects, including those that impact ultrasound findings. During follow-up of childhood cancer survivors (CCSs), we often detected sporadic renal angiomyolipomas without histological confirmation (SAMLs), which is why we initiated this study. We compared the occurrence of SAML in CCSs to the previously reported data from a non-cancer population and correlated SAML with cancer treatment-related factors. Methods The cohort included 1098 CCSs (median age at cancer diagnosis (dg) 4.3 years) who had ultrasound follow-up (2014–2019). Of the CCSs, 525 (48%) were female, 132 (12%) had subsequent neoplasms (SNs), and 110 (10%) had genetic syndromes. CCSs were treated for lymphomas 269 (24%) and solid tumors 829 (76%). None of the CCSs had tuberous sclerosis complex (TSC). Results SAML developed in 48 (4.4%) CCSs; of these, 20 (42%) had SNs. The coincidence of SAMLs and SNs was found in CCSs with a follow-up period exceeding 20 years. The median age at SAML dg was 27.9 years (interquartile range (IQR) 22.3–34.1), and the median time to SAML dg was 22.6 years (IQR 17.4–27.6). Twenty-one (44%) CCSs developed multiple or bilateral SAMLs lesions; of these, six (12%) were in the radiotherapy field. SAML occurrence correlated with radiotherapy of the retroperitoneum (1.65-fold higher with 95% CI 0.90–3.02). The correlations with other cancer treatment factors and with female sex were less clear. Conclusion This study revealed the occurrence of SAMLs in CCSs to be 10 times higher than that in non-cancer studies. The current characteristics of CCSs with SAMLs: younger age, and more bilateral or multiple lesions are more similar to TSC associated angiomyolipoma. Moreover, we observed a coincidence of SAMLs with SNs. Our results support the hypothesis that SAML development in CCSs is not simply a late effect of therapy, and indicates other factors are involved in SAML development.

show abstract

Section: Introductionmentioning

confidence: 99%

“… 4 , 5 They usually present as unilateral single lesions. 1–3 The prevalence in the general population is reported to be 0.1–0.44%. 4 , 5 Previous studies in non-cancer populations reported a higher SAML prevalence in women, and the effect of sex hormones was considered.…”

Section: Introductionmentioning

confidence: 99%

Is There a Higher Incidence of Sporadic Renal Angiomyolipoma in Childhood Cancer Survivors?

Kruseová

Gottfriedová

Zichová

et al. 2021

CLEP

View full text Add to dashboard Cite

show abstract

“…Güncel bir çalışmada kanama görülen AML' lerin ortalama boyutu 8 cm, kanama görülmeyen olguların ortalama boyutu 4.1 cm olarak bulunmuş, kanama tahmini için sınır değeri 7.35 cm olarak bildirilmiştir (3). Ayrıca başka bir çalışmada kanayan tümörler ortalama 11.4 cm, kanamayanlar 5 cm olarak bulunmuştur (16).…”

Section: Takip Ve Kanamaunclassified

“…Bu çalışmada ise 3 olguda kanama saptanmış olup ortalama tümör boyutu 220 mm (min-maks: 84-363 mm)' dir. Güncel bir çalışmada sporadik olarak saptanan AML' lerin ortalama boyutu 47 mm olarak bulunmuştur (3). Bu çalışmada ortalama tümör boyutu 39.2 mm (5-363 mm)' dir.…”

Section: Takip Ve Kanamaunclassified

See 1 more Smart Citation

Renal Anji̇omyoli̇pom Olgularinin 5 Yila Kadar Taki̇p Görüntüleme Bulgulari

Yılmaz¹

2019

Kocatepe Tıp Dergisi

View full text Add to dashboard Cite

Bu çalışmanın amacı takip görüntülemeleri olan renal anjiomyolipom (AML) olgularını tümör boyut değişikliği ve gelişen komplikasyonlar açısından değerlendirmektir. GEREÇ VE YÖNTEM: Görüntüleme tetkikleri ile renal AML tanısı konan ve takip görüntülemeleri bulunan olguların tümör boyutundaki değişiklikler, takipte gelişen komplikasyonlar ve yapılan girişimsel işlemler retrospektif olarak incelenmiştir. BULGULAR: Abdominal görüntüleme ile tanısı konan 149 renal AML olgusunun 41' ine (18E, 23K) takip görüntüleme yapıldığı saptanmıştır. Ortalama yaş 58.4 (minmaks: 31-81)' dür. Takip süresi ortalama 28.3 ay (minmaks: 3-60)' dır. 38 olguda (%93) tek taraflı (21 sol (%51), 17 sağ (%41)), 3 olguda (%7) çift taraflı AML saptanmıştır. İlk görüntülemede ortalama AML boyutu 39.2mm (minmaks: 5-363)' dir. 28 olguda (%68) AML boyutu 40mm' den küçük, 13 olguda (%32) ise 40mm' den büyüktür. 32 olguda (%78) tümör boyutu değişmemiştir. 5 olguda (%12) tümör boyutunda artış mevcut olup ortalama artış 6 mm (min-maks: 3-10 mm)' dir. 3 olguda (%7) takipte kanama görülmüştür. 3 olguya arteryel embolizasyon işlemi yapılmış, takipte ortalama boyut azalması 12.5 mm (minmaks: 10-15)' dir. 1 olguya cerrahi rezeksiyon yapılmıştır. SONUÇ: Renal AML' ların boyutu genel olarak değişmemekle birlikte %12 olguda boyut artışı görülebilir. Semptomatik, büyük boyutlu ve takipte boyut artışı gösteren AML olgularında retroperitoneal kanama ve renal hasar gibi komplikasyonlardan korunmak için girişimsel işlemler yapılabilir.

show abstract