Clinical behavior of T1–T2 squamous cell carcinoma of the oral cavity

Cariati, Paolo; Ozan, Daniel Pampin; Corcóles, Costantin Gonzalez; Tursun, Ramzey; Barreño, Marta Peña; Ferrari, Silvano; Rodriguez, Susana Arroyo

doi:10.1016/j.jcms.2020.09.011

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…(2020) 5 % «скрытых» метастазов были выявлены при толщине опухоли, не превышающей 4 мм. Увеличение толщины ≥4 мм повышает риск метастазирования почти в 10 раз (до 45,7 %) [19]. В работе J.-H. Shin 2020 г. показано, что «скрытые» метастазы при толщине менее 3 мм не обнаруживаются, тогда как ее увеличение повышает риск «скрытого» метастазирования в 20 раз (до 22 %) [20,25].…”

Section: Discussionunclassified

Improved diagnostics of “concealed” metastases in patients with сТ1–2N0М0 oral squamous cell carcinoma

Мудунов

Гельфанд

Кропотов

et al. 2022

Opuholi golovy i šei

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Introduction. Oral squamous cell carcinoma is associated with a high risk of regional metastasis even in early stages (T1–2N0M0). Morphological examination reveals concealed metastases in 20 % of removed clinically unaffected lymph nodes.Objective – to evaluate the effectiveness of flow cytometry for detection of concealed metastases in sentinel lymph nodes as an indication for cervical lymph node dissection in patients with stage сT1–2N0M0 oral squamous cell carcinoma.Materials and methods. This study included 27 patients, including 13 patients (48.1 %) with stage T1N0M0 cancer and 14 patients with stage T2N0M0 cancer (51.9 %). At the first stage, all participants underwent primary tumor removal and cervical lymph node dissection with sentinel lymph node examination. After mobilization, half of these lymph nodes was used for routine morphological examination followed by immunohistochemical examination, while the second half of them was analyzed using flow cytometry. Then we compared the results obtained.Results. We examined 46 removed sentinel lymph nodes from 27 patients. Conventional histological examination revealed 4 concealed metastases (8.7 %). Polymerase chain reaction allowed us to detect another 16 metastases (37.8 %). Levels I, II, and III lymph nodes were most frequently affected. Flow cytometry demonstrated that 20 % of patients with a <4 mm invasion had concealed metastases, whereas patients with a 4 to 8 mm invasion had concealed metastases in 60 % of cases. Median follow-up time was 20.4 ± 11.7 months (range: 2.2 to 42.5 months; median 19.5 months). All participants were alive during this time. Seventeen out of 27 patients with stage T1–2N0M0 disease (63 %) were found to have concealed metastases, while the remaining ten patients (37 %) had no metastasis. One patient with stage T1N0M0 oral floor squamous cell carcinoma underwent the removal of the primary tumor and sentinel lymph node. Morphological examination and flow cytometry showed no metastatic lesions. After 14.8 months, the patient developed ipsilateral regional CN3 metastasis. The three-year progression-free survival rate was 94.7 ± 5.1 %.Conclusion. Highly sensible and rapid flow cytometry can become the method of choice in the diagnosis of metastases and deciding on cervical lymph node dissection in patients with cN0 disease. The study is still ongoing.

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Section: Discussionunclassified

Improved diagnostics of “concealed” metastases in patients with сТ1–2N0М0 oral squamous cell carcinoma

Мудунов

Гельфанд

Кропотов

et al. 2022

Opuholi golovy i šei

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“…Oral squamous cell carcinoma is a serious and relatively frequent disease of the oral cavity and, unfortunately, also belongs to the most common malignancies in the orofacial region [1]. The estimated age-standardized rate incidence in Europe is 16.9, in the European Union 17.0, followed by the mortality of 7.1 and 6.7 respectively per 100 000 for the year 2020 [2].…”

Section: Introductionmentioning

confidence: 99%

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

Pošta,

Kolk,

Pivovarčíková

et al. 2023

Preprint

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The influence of preoperative examination of oral squamous cell carcinoma (OSCC) mucosal surrounding by VELscope (Visually Enhanced Lesion Scope) on the radicality of surgical treatment of OSCC was the goal of this study.It is the first analysis of its kind with a total number of 122 patients suffering from OSCC with homogenous distribution of different tumor stages randomized into a study and a control group and enrolled in our study after meeting the inclusion criteria. The preoperative checkup by VELscope accompanied by the marking of the range of a loss of fluorescence in the study group was performed before the surgery. We have developed a unique mucosal tattoo marking technique for this purpose. The pathohistological results after surgical treatment, i.e. the margin status, were then compared. We achieved the pathological free margin (pFM) in 55 patients, the pathological close margin (pCM) in 6 cases and we encountered no case of the pathological positive margin (pPM) in the mucosal layer in the study group. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases and pFM in 40 of all cases in the mucosal layer. This study proved that the preoperative autofluorescence evaluation of a tumor mucosal surrounding can enhance the ability to reach the pFM resection.

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“…Oral squamous cell carcinoma is a serious and relatively frequent disease of the oral cavity and, unfortunately, also belongs among the most common malignancies in the orofacial region [1]. The estimated age-standardized rate of incidence in Europe is 16.9, and in the European Union it is 17.0, followed by a mortality of 7.1 and 6.7, respectively, per 100,000 for the year 2020 [2].…”

Section: Introductionmentioning

confidence: 99%

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

Pošta,

Kolk,

Pivovarčíková

et al. 2023

Diagnostics

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In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope—VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was tested on a group of 122 patients suffering from OSCC, randomized into a study and a control group enrolled in our study after meeting the inclusion criteria. The preoperative checkup via VELscope, accompanied by the marking of the range of a loss of fluorescence in the study group, was performed before the surgery. We developed a unique mucosal tattoo marking technique for this purpose. The histopathological results after surgical treatment, i.e., the margin status, were then compared. In the study group, we achieved pathological free margin (pFM) in 55 patients, pathological close margin (pCM) in 6 cases, and we encountered no cases of pathological positive margin (pPM) in the mucosal layer. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases, and pFM in 40 of all cases in the mucosal layer. This study demonstrated that preoperative autofluorescence assessment of the mucosal surroundings of OSCC increased the ability to achieve pFM resection 4.8 times in terms of lateral margins.

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Clinical behavior of T1–T2 squamous cell carcinoma of the oral cavity

Cited by 5 publications

References 19 publications

Improved diagnostics of “concealed” metastases in patients with сТ1–2N0М0 oral squamous cell carcinoma

Improved diagnostics of “concealed” metastases in patients with сТ1–2N0М0 oral squamous cell carcinoma

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

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