Clinical, behavioural and neural validation of the PANSS amotivation factor

Kaliuzhna, Mariia; Kirschner, Matthias; Carruzzo, Fabien; Hartmann-Riemer, Matthias N.; Bischof, Martin; Seifritz, Erich; Tobler, Philippe N.; Kaiser, Stefan

doi:10.1016/j.schres.2020.04.018

Cited by 14 publications

(11 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reported two-factor structure comprise of: (1) an apathy domain, including emotional withdrawal, passive social withdrawal, and active social avoidance and (2) a diminished expression domain, including blunted affect, poor rapport, lack of spontaneity, and motor retardation (13,14). This structure has been supported by a confirmatory factor analysis in an adult schizophrenia sample (19), and validated against corresponding subdomains of the Brief Negative Symptom Assessment Scale (20). Investigations of the two negative symptom domains, separately, have reported differential associations with other clinical aspects of psychotic disorders and neurobiology, including functional outcome (21), cognitive impairments (22,23), neuronal task activation (24), and white matter connectivity (25).…”

Section: Introductionmentioning

confidence: 81%

Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis

et al. 2022

View full text Add to dashboard Cite

Background: Early-onset psychosis (EOP) is among the leading causes of disease burden in adolescents. Negative symptoms and cognitive deficits predicts poorer functional outcome. A better understanding of the association between negative symptoms and cognitive impairment may inform theories on underlying mechanisms and elucidate targets for development of new treatments. Two domains of negative symptoms have been described in adult patients with schizophrenia: apathy and diminished expression, however, the factorial structure of negative symptoms has not been investigated in EOP. We aimed to explore the factorial structure of negative symptoms and investigate associations between cognitive performance and negative symptom domains in adolescents with EOP. We hypothesized that (1) two negative symptom factors would be identifiable, and that (2) diminished expression would be more strongly associated with cognitive performance, similar to adult psychosis patients.Methods: Adolescent patients with non-affective EOP (n = 169) were included from three cohorts: Youth-TOP, Norway (n = 45), Early-Onset Study, Norway (n = 27) and Adolescent Schizophrenia Study, Mexico (n = 97). An exploratory factor analysis was performed to investigate the underlying structure of negative symptoms (measured with the Positive and Negative Syndrome Scale (PANSS)). Factor-models were further assessed using confirmatory factor analyses. Associations between negative symptom domains and six cognitive domains were assessed using multiple linear regression models controlling for age, sex and cohort. The neurocognitive domains from the MATRICS Consensus Cognitive Battery included: speed of processing, attention, working memory, verbal learning, visual learning, and reasoning and problem solving.Results: The exploratory factor analysis of PANSS negative symptoms suggested retaining only a single factor, but a forced two factor solution corroborated previously described factors of apathy and diminished expression in adult-onset schizophrenia. Results from confirmatory factor analysis indicated a better fit for the two-factor model than for the one-factor model. For both negative symptom domains, negative symptom scores were inversely associated with verbal learning scores.Conclusion: The results support the presence of two domains of negative symptoms in EOP; apathy and diminished expression. Future studies on negative symptoms in EOP should examine putative differential effects of these symptom domains. For both domains, negative symptom scores were significantly inversely associated with verbal learning.

show abstract

Section: Introductionmentioning

confidence: 81%

Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…We calculated the subdimension of negative symptoms, according to the PANSS five-factor model 44 . In addition, we also used the PANSS Amotivation factor 45 , 46 , which highly correlated with Brief Negative Symptoms Scale (BNSS 47 ) and effort-based decision-making 48 . The following cognitive tests were administered to all participants: Letter Digit Sequencing span of WAIS-IV, revised shopping test 49 , and the fNART.…”

Section: Methodsmentioning

confidence: 99%

Getting a tool gives wings even in schizophrenia: underestimation of tool-related effort in a motor imagery task

et al. 2021

View full text Add to dashboard Cite

Humans frequently use tools to reduce action-related efforts. Interestingly, several studies have demonstrated that individuals had tool-related biases in terms of perceived effort reduction during motor imagery tasks, despite the lack of evidence of real benefits. Reduced effort allocation has been repeatedly found in schizophrenia, but it remains unknown how schizophrenia patients perceive tool-related benefits regarding effort. Twenty-four schizophrenia patients and twenty-four nonclinical participants were instructed to move the same quantities of objects with their hands or with a tool in both real and imagined situations. Imagined and real movement durations were recorded. Similarly to nonclinical participants, patients overestimated tool-related benefits and underestimated tool-related effort in terms of time when they mentally simulated a task requiring the use of a tool. No association between movement durations and psychotic symptoms was found. Our results open new perspectives on the issue of effort in schizophrenia.

show abstract

“…Finally, concluding from available data (Shaffer et al, 2015;Abram et al, 2017;Walton et al, 2018;Li et al, 2018;Bègue et al, 2020;Brady et al, 2019, Guessoum et al, 2020, Kaliuzhna et al, 2020, we hypothesize, that the most robust association between avolition/anhedonia/asociality symptoms (and/or social amotivation factor) and abnormal WM changes will be manifested within the fronto-temporo-parietal regions, such as orbitofrontal cortex, cingulate gyrus, middle and superior temporal gyrus, and precuneus.…”

Section: Introductionmentioning

confidence: 96%

“…The concurrent validity of both BNSS and PANSS is high and a recent study (Kaliuzhna et al, 2020) revealed that both amotivation factors reach a relatively high negative association with diminished left ventral striatal activation. However, the effect sizes for BNSS were much higher and the authors emphasize that the use of specialized scales like BNSS is crucial in MRI studies directly addressing negative symptoms (Kaliuzhna et al, 2020).…”

Section: Introductionmentioning

confidence: 97%

“…BNSS belongs to the second generation of the negative symptoms scales and consists of 5 specific subdomains of negative symptoms: blunted affect, alogia, asociality, anhedonia, and avolition (Garcia-Portilla et al, 2015;Kumari et al, 2017;Ahmed et al, 2019;Strauss et al, 2019), which may have the potential to separate neurobiological substrates and to become new therapeutic targets (Kirkpatrick et al, 2011). The concurrent validity of both BNSS and PANSS is high and a recent study (Kaliuzhna et al, 2020) revealed that both amotivation factors reach a relatively high negative association with diminished left ventral striatal activation. However, the effect sizes for BNSS were much higher and the authors emphasize that the use of specialized scales like BNSS is crucial in MRI studies directly addressing negative symptoms (Kaliuzhna et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients – a DTI study

Adamczyk¹,

Płonka²,

Kruk³

et al. 2021

Acta Neurobiologiae Experimentalis

View full text Add to dashboard Cite

Recent MRI studies have shown that abnormal functional connections in schizophrenia coexist with subtle changes in the structure of axons in the brain. However, there is a discrepancy in the literature concerning the relationship between white matter abnormalities and the occurrence of negative psychopathological symptoms. In the present study, we investigate the relationship between the altered white matter structure and specific psychopathology symptoms, i.e., subscales of Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptoms Scale (BNSS) in a sample of schizophrenia outpatients. For investigation on white matter abnormalities in schizophrenia, the diffusion tensor imaging analysis of between-group differences in main diffusion parameters by tract-based spatial statistics was conducted on schizophrenia outpatients and healthy controls. Hence, the correlation of PANSS and BNSS psychopathology subscales in the clinical group with fractional anisotropy was analyzed in the 17 selected cortical regions of interest. Presented between-group results revealed widespread loss of white matter integrity located across the brain in schizophrenia outpatients. Results on the white matter relationship with psychopathology revealed the negative correlation between fractional anisotropy in the left orbital prefrontal cortex, right Heschl's gyrus, bilateral precuneus and posterior cingulate cortex and the severity of asociality, as assessed with the BNSS. In conclusion, the presented study confirms the previous evidence on the widespread white matter abnormalities in schizophrenia outpatients and indicates the existence of the subtle but specific association between fractional anisotropy in the fronto-temporo-parietal regions with the asociality.

show abstract

Clinical, behavioural and neural validation of the PANSS amotivation factor

Cited by 14 publications

References 47 publications

Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis

Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis

Getting a tool gives wings even in schizophrenia: underestimation of tool-related effort in a motor imagery task

On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients – a DTI study

Contact Info

Product

Resources

About