Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases

Mahdy, Karam A; Ahmed, Hanaa H.; Mannaa, Fathia A.; Abd-El-Shaheed, A

doi:10.3748/wjg.v13.i5.785

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…The effect of gender remains insufficiently defined (11). In liver diseases, serum level of IGF-1 is thought to provide a useful marker of the organ function, independently of etiology and patient age (20,24,42). In the CH-C group, our investigations confirmed the negative correlation between concentration of S-IGF-1 and patient age described by other authors (43,44).…”

Section: Discussionsupporting

confidence: 78%

The insulin-like growth factor-1 and expression of its binding protein-3 in chronic hepatitis C and hepatocellular carcinoma

Adamek¹,

Kasprzak²,

Mikos³

et al. 2013

Oncology Reports

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Section: Discussionsupporting

confidence: 78%

The insulin-like growth factor-1 and expression of its binding protein-3 in chronic hepatitis C and hepatocellular carcinoma

Adamek¹,

Kasprzak²,

Mikos³

et al. 2013

Oncology Reports

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“…Also, 25(OH)D and PTH were not independent predictors of bone turnover markers, indicating that vitamin D and PTH are not involved in the relationship of these liver enzymes with bone remodeling. We found positive correlations between 25(OH)D and ALP, and between PTH and bilirubin, which indicate that vitamin D insufficiency and SHPT may affect specific liver functions, as it was previously reported for the PTH-bilirubin association [102,103].…”

Section: Adipokines and Markers Of Hepatic Mineral And Bone Metabolismsupporting

confidence: 87%

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

Fisher

2014

J Endocrinol Metab

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“…but showing nonsignificant decrease in serum albumin activity in the untreated HCV infected group when compared to control group, this result agree with the result obtained by Shaker et al [35] who reported that plasma Albumin level showed a significant decrease as compared to normal control group. In the present study there was a significant decrease in serum T. Protein level in the untreated HCV infected group when compared to control group, this result agree with that showed by Mahdy et al [36].…”

Section: Discussionsupporting

confidence: 93%

The Influence of C936T Gene in Wild of the Vascular Endothelial Growth Factor and Biochemical Variants Analysis for Alpha-Fetoprotein in Hepatocellular Carcinoma Patients in Egypt

Elkhashab¹,

M²,

H³

et al. 2017

J Cancer Sci Ther

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Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors. It is important to detect disease and recurrence at its earlier period. The aim of this study was to evaluate the influence of the C936T polymorphism of the VEGF and Alfa feto-Protein (AFP) on Hepatocellular carcinoma (HCC), Hepatitis C Virus (HCV) and control groups. Also, estimation of serum AFP and correlation with other parameters was studied. In this study was included 75 subjects, 25 patients with HCV, 25 patients with confirmed HCC and 25 healthy volunteers were subjected to abdominal ultrasonography, AFP and VEGF were assessed. The statistical analysis will include the Fisher exact test, T test and the multivariate regression, with significance level P<0.05 (AU). The result has showed that Serum level of AFP was significantly higher in HCC group when compared with control group and There was a nonsignificant increase in serum (AFP) level in the untreated HCV infected group compared to control group and also there was a nonsignificant increase in serum (AFP) activity in the HCC group compared to untreated HCV infected group with a (P value = 0.203). the influence of the C936T polymorphism of the VEGF distribution of the studied groups showing that Positive gene have higher incidence of HCV and HCC infection than Negative gene, when compared to control group. Sensitivity and specificity of markers in diagnosis of HCC were 52% and 40% respectively for AFP using a cutoff value of 3.39 ng/ml. VEGF may be useful marker for detection of HCC in addition to traditional markers.

show abstract

Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases

Cited by 18 publications

References 30 publications

The insulin-like growth factor-1 and expression of its binding protein-3 in chronic hepatitis C and hepatocellular carcinoma

The insulin-like growth factor-1 and expression of its binding protein-3 in chronic hepatitis C and hepatocellular carcinoma

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

The Influence of C936T Gene in Wild of the Vascular Endothelial Growth Factor and Biochemical Variants Analysis for Alpha-Fetoprotein in Hepatocellular Carcinoma Patients in Egypt

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