Clinical Biochemical Indicators and Intestinal Microbiota Testing Reveal the Influence of Reproductive Age Extending from the Mother to the Offspring

Li, Xiaoqing; Zhang, Bing; Zheng, Jiayong; Chen, Haiying; Zheng, Jianqiong; Xu, Xiaomin; Wang, Wenhuan; Sun, Congcong; Lin, Wenjing; Chen, Kaixin; Xu, Zuyuan; Zhang, Hongping; Wang, Jinfeng

doi:10.1128/spectrum.01076-22

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…In exploring the relationship between age at childbirth and the initial gut microbiota of newborns, we previously found the same trend of microbial changes between mothers and offspring in terms of alpha diversity and Bray-Curtis distance ( Li et al, 2022 ). Similarly, in the case of pregnant women with GDM, we observed a concordance of microbial variations between mothers and neonates, such as Prevotella , Streptococcus, and Bacteroides ( Wang et al, 2018 ).…”

Section: Intergenerational Health Care and Interventions Targeting Th...mentioning

confidence: 77%

“…Maternal microbiome from gut, vagina, mouth, milk, and skin are regarded as the main sources of neonatal microbiota ( Wang et al, 2020 ), with gut strains providing the largest contribution of colonizing microorganisms ( Ferretti et al, 2018 ) and vagina being the primary viruses source of vaginally newborns ( Wang et al, 2022 ). The maternal microbiota changes as a result of having GDM or increasing age, with subsequent synergistic changes in the neonatal microbiota ( Wang et al, 2018 ; Li et al, 2022 ), which may impact the initial microbiota of infants and affect their long-term health. For example, increased L. iners transmission from mothers and neonates was observed under GDM condition ( Wang et al, 2018 ).…”

Section: Intergenerational Health Care and Interventions Targeting Th...mentioning

confidence: 99%

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Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Gao

Wang

2023

Protein &Amp; Cell

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Microbes are commonly sensitive to shifts in the physiological and pathological state of their hosts, including mothers and babies. From this perspective, the microbiome may be a good indicator for diseases during pregnancy and has the potential to be used for perinatal health monitoring. This is embodied in the application of microbiome from multi body sites for auxiliary diagnosis, early prediction, prolonged monitoring, and retrospective diagnosis of pregnancy and infant complications, as well as nutrition management and health products developments of mothers and babies. Here we summarized the progress in these areas and explained that the microbiome of different body sites is sensitive to different diseases and their microbial biomarkers may overlap between each other, thus we need to make a diagnosis prudently for those diseases. Based on the microbiome variances and additional anthropometric and physical data, individualized responses of mothers and neonates to meals and probiotics/prebiotics were predictable, which is of importance for precise nutrition and probiotics/prebiotics managements and developments. Although a great deal of encouraging performance was manifested in previous studies, the efficacy could be further improved by combining multi-aspect data such as multi-omics and time series analysis in the future. This review reconceptualizes maternal and infant health from a microbiome perspective, and the knowledge in it may inspire the development of new options for the prevention and treatment of adverse pregnancy outcomes and bring a leap forward in perinatal health care.

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Section: Intergenerational Health Care and Interventions Targeting Th...mentioning

confidence: 77%

Section: Intergenerational Health Care and Interventions Targeting Th...mentioning

confidence: 99%

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Gao

Wang

2023

Protein &Amp; Cell

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Maternal dysbiosis produces long-lasting behavioral changes in offspring

Hudobenko,

Di Gesù,

Mooz

et al. 2024

Mol Psychiatry

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A mixed-methods study on enhancing the service system of human assisted reproductive technologies: A case study in Hangzhou, China

Rong,

Wu,

Chang

et al. 2024

Preprint

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Background: Infertility is a widespread medical condition Assisted Reproductive Technology (ART) stands as an effective treatment for infertility; however, the existing reproductive healthcare system lacks comprehensive development.. Methods: Employing both stratified and random sampling methods, one hospital from each provincial and municipal level in Hangzhou was selected, yielding a sample comprising 139 patients and 8 medical personnel. The analysis utilized a mixed-methods research approach. Results: 43.88% of the respondents considered a price range of 20,000 to 40,000 RMB as acceptable. Regarding the desired time to conceive, 73.38% of respondents aimed to conceive within six months. Patients under 30 and those between 30 to 35 years showed greater preference for assisted reproductive hospitals with higher success rates. Patients intending for a single pregnancy were likelier than those considering multiple pregnancies to view comprehensive or fixed-sum insurance coverage as more influential in increasing their willingness to conceive. Conclusion: Standardization of a well-coordinated and organized assisted reproductive medical consortium should be promoted. Enhancement of the diagnosis and treatment level in assisted reproductive services is essential. Humanistic care should be reinforced. A scientifically guided approach to determining assisted reproductive service pricing should progressively inform the reasonable expansion of medical insurance coverage. Enhanced supervision over abortion institutions is crucial. A societal atmosphere conducive to marriage and childbearing at an appropriate age should be fostered.

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Clinical Biochemical Indicators and Intestinal Microbiota Testing Reveal the Influence of Reproductive Age Extending from the Mother to the Offspring

Cited by 3 publications

References 42 publications

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Maternal dysbiosis produces long-lasting behavioral changes in offspring

A mixed-methods study on enhancing the service system of human assisted reproductive technologies: A case study in Hangzhou, China

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