Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone

Fieni, F.; Martal, J.; Marnet, Pierre‐Guy; Siliart, Brigitte; Guittot, Franck

doi:10.1016/j.theriogenology.2006.02.026

Cited by 36 publications

(72 citation statements)

References 10 publications

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“…This suggested that the occurrence of pyometra was closely related to the status of uteri in female dogs and progesterone had a more critical role in pyometra occurrence as compared with estrogen. This is consistent with previous studies (19,20). A study by Nomura et al (21) demonstrated that the success rate of inducing pyometra was highest when inoculating E. coli at the diestrus stage.…”

Section: Discussionsupporting

confidence: 94%

Escherichia coli virulence influences the roles of sex hormone receptors in female dogs with simulated pyometra

Chen

Hou

2017

Experimental and Therapeutic Medicine

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The present study aimed to investigate whether Escherichia coli virulence affects the roles of sex hormone receptors in female dogs with simulated pyometra. A total of 33 healthy, nulliparous, crossbred female dogs were divided into four groups, with 10 dogs in each of the three experimental groups and 3 dogs in the control group. Estradiol was administrated to female dogs in group 1 continuously at 0.6–4.8 mg/kg twice daily for 12 days (the dose doubled every three days), followed by intramuscular injection of 0.2–1.8 mg/kg progesterone. The progesterone was administrated with an initial dose of 0.2 µg/kg and increased 0.2 mg/kg every three days, twice daily until the maximum of 1.8 mg/kg for 24 days and maintained at 1.8 mg/kg for 19 days. Progesterone only was administrated at 1.8 mg/kg in group 2 (twice daily) for 55 continuous days and only estradiol was administered with an initial dose of 0.6 µg/kg (dose doubled every 3 days for 12 days) in group 3 twice daily and maintained at 4.8 mg/kg for the following 43 days. A strongly virulent E. coli strain, nau-b, and a weakly virulent strain, nau-i, were screened. On the 12th day of diestrus, 5 female dogs in each of the experimental groups were inoculated with E. coli nau-i strain, while the other five in each group were inoculated with nau-b strain. Histopathological changes of uterine tissues were microscopically observed 50 days after E. coli inoculation and hormone receptor expression levels were detected by quantitative polymerase chain reaction. Simulated pyometra was observed in dogs administrated with progesterone alone or progesterone combined with estradiol. The clinical symptoms and histopathological observation demonstrated that inoculation with strongly virulent E. coli strain, nau-b, caused earlier onset of pyometra symptoms and more severe pyometra symptoms compared with the weakly virulent E. coli strain, nau-i. Furthermore, estrogen and progesterone receptor levels in dogs with pyometra inoculated with E. coli strain nau-i was higher than those in dogs with pyometra inoculated with E. coli strain nau-b. These results indicated that E. coli affects the roles of sex hormone receptors in female dogs with simulated pyometra.

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Section: Discussionsupporting

confidence: 94%

Escherichia coli virulence influences the roles of sex hormone receptors in female dogs with simulated pyometra

Chen

Hou

2017

Experimental and Therapeutic Medicine

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“…Compared to rats (Rattus norvergicus), oxytocin plasma levels found in cats are lower, since the concentration for rodents is reported to lie between 7.7±1.1 (pmol/L) (Carter and Lightman 1987) and 19.5±4.5 (pmol/L) (Higuchi et al 1985). Fieni et al (2006) have described oxytocin plasma levels of 37.7±9.5 (pmol/L) in pregnant female cats, which is well above those encountered in males, thereby highlighting the importance of this hormone during pregnancy, labor, and lactation (Cooke et al 1998;Kotwica et al 1999).…”

Section: Resultsmentioning

confidence: 96%

Pre-and post-puberty physiological plasma oxytocin concentrations in male domestic cats (Felis silvestris catus)

et al. 2012

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RESUMO.-ȑConcentrações ϐisiológicas plasmáticas de ocitocina pré e pós-puberal em gatos machos (Felis silvestris catus).]A ocitocina é um hormônio secretado pela neurohipóϐise através da estimulação dos neurônios dos núcleos supraópticos e paraventriculares do hipotálamo. Com o intuito de determinar as concentrações ϐisiológicas de ocitocina em gatos domésticos foram coletadas amostras de sangue de 15 animais (Felis silvestris catus) machos, nos períodos pré e pós puberdade (quarto e oitavo mês de vida), sendo utilizada a técnica de radioimunoensaio para tal determinação. Na primeira dosagem a concentração mé-dia foi de 2,54±0,24 (μg/dL), e na segunda 2,53±0,28 (μg/ Pre-and post-puberty physiological plasma oxytocin concentrations in male domestic cats (Felis silvestris catus) The hormone oxytocin is released by the neuropituitary gland through stimulation of the neurons of the supraoptic and paraventricular nuclei of the hypothalamus. In order to determine the physiological concentrations of this hormone in domestic cats, blood samples were collected from 15 male animals (Felis silvestris catus) during the pre-and post-puberty periods (at four and eight months of age, respectively). Oxytocin determination was accomplished by radioimmunoassay. The average oxytocin concentrations measured in the preand post-puberty periods were 2.54±0.24 (μg/dL) and 2.53±0.28 (μg/dL), respectively, and there were no statistical differences between these measurements. Because there are few literature on the analysis of this hormone, especially in the case of male Felis silvestris catus, more studies on the inϐluence of oxytocin on the physiology and reproduction of this species should be conducted under maintenance and situations of stress (such as transportation), and other routine events.

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“…Aglepristone, an antiprogestin, can be effectively used to induce abortion in queens (Fieni et al. 2006; Georgiev et al.…”

Section: Discussionmentioning

confidence: 99%

“…Two recent studies have reported no negative effects of treatment with aglepristone on subsequent fertility, as treated queens normally returned to oestrus and became pregnant after breeding (Georgiev et al. 2005; Fieni et al. 2006).…”

Section: Discussionmentioning

confidence: 99%

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Histological Changes of the Feline Cervix, Endometrium and Placenta after Mid‐gestational Termination of Pregnancy with Aglepristone

Georgiev

Wehrend²,

Penchev

et al. 2008

Reprod Domestic Animals

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This study was conducted to investigate endometrial and placental structural changes that occurred in response to mid-gestational termination of pregnancy in queens using aglepristone, a progesterone receptor antagonist. Thirteen European Shorthair pregnant queens were either treated with aglepristone (10 mg/kg body weight; subcutaneously) twice on days 25 and 26 after first mating (am; group I; n = 9), or remained untreated and served as control (group II; n = 4). Queens of group I were ovariohysterectomized between days 30 and 41 am, either at the onset (n = 3) or during (n = 1) abortion and 12 h (n = 1), 24 h (n = 3) or 10 days after abortion (n = 1). Queens of group II were ovariohysterectomized on day 30 am. Tissue was collected from the cervix, and the interplacental zone as well as the paraplacenta/placental girdle of the uterus, subjected to standard histological procedures and evaluated using light microscopy. During abortion, gaps appeared within the paraplacenta and the placental girdle which were filled with blood, leading to an embryo-maternal disconnection. Blood was also observed within the uterine lumen as well as the interstitial mucosal stroma of the cervix and the placental girdle zone and probably originated from damaged venules, whilst arterioles remained intact. As the interval between abortion and surgery increased, the interstitial and luminal haemorrhages became less pronounced and completely disappeared except interstitial remnants 10 days after abortion. The endometrial regeneration was not fully completed on day 10 after abortion and a few cystically dilated glands were evident. In conclusion, abortion of queens through aglepristone given during mid-gestation is assumed to be the result of damage of uterine venules. This leads to an interstitial haemorrhages and bleeding into the uterine lumen, subsequently resulting in utero-placental detachment.

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Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone

Cited by 36 publications

References 10 publications

Escherichia coli virulence influences the roles of sex hormone receptors in female dogs with simulated pyometra

Escherichia coli virulence influences the roles of sex hormone receptors in female dogs with simulated pyometra

Pre-and post-puberty physiological plasma oxytocin concentrations in male domestic cats (Felis silvestris catus)

Histological Changes of the Feline Cervix, Endometrium and Placenta after Mid‐gestational Termination of Pregnancy with Aglepristone

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